Hotel vacation rentals in Upstate South Carolina

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Top-rated hotel rentals in Upstate South Carolina

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Superhost

Nature lodge in Sylva

4.75 out of 5 average rating, 110 reviews

Room 201. Click on photos for more rooms.

The Tahimek Mountain Lodge is located in a secluded, pristine, mountain cove. Surrounded by tall hardwood trees, with views of the sunset and surrounding mountains. A peaceful retreat for guests seeking a quiet place to relax and enjoy nature. We only accept children 13 years or older. Pets are not allowed. WiFi Tahimek Password Asheville1954 You will be provided specific check-in instructions at time of booking. If you require assistance please ring door bell at Office entrance.

Mar 8 – 15

R1,148 ZAR per night

Superhost

Nature lodge in Greenville County

4.88 out of 5 average rating, 8 reviews

Cabin near Pretty Place!

Are you tired of the business of every day life? Do you feel the need to get away and just relax? Well, you found the right place! With a queen size bedroom, this Cabin near Pretty Place is just the place for you. 10 minutes away from anything you would need for the weekend. It is only 20 minutes away Table Rock State Park and from the town of Travelers Rest with fun restaurants and the Swamp Rabbit trail. It is also 50 minutes from the beautiful city of Greenville and Pretty Place Chapel.

Aug 6 – 13

R2,358 ZAR per night

Guest favorite

Shared room in Greenville

4.91 out of 5 average rating, 74 reviews

TwinXL Bed in 4-Person Female Shared Rm in Hostel

PLEASE TYPE IN "MODAL HOSTEL" IN ANY SEARCH ENGINE TO LEARN MORE ABOUT OUR PROPERTY PRIOR TO BOOKING You're booking a single Twin XL bed in a 4-person FEMALE shared room in a 20-bed, bespoke hostel, coffee shop, and art gallery in historic downtown Greenville, South Carolina. Modal serves as a hub for traveling artisans with a mixture of shared bunk-style rooms and private hotel accommodations. Our sweet spot is communal living and artistic osmosis for creative professionals & travelers.

Sep 18 – 25

R920 ZAR per night

Superhost

Boutique hotel in Sunset

4.56 out of 5 average rating, 9 reviews

"Muskrat" room at Wilderness Retreat Center

The Lakeside Lodge Hostel is part of a retreat center located close to many outdoor activities in the Upstate of South Carolina, close to the North Carolina border. There are waterfalls, hiking trails, lakes, and great State Parks all within 30 minutes. The Hostel offers clean, comfortable rooms. The Lakeside Lodge has a kitchen, living room, and pavilion that guests can access, as well as all the outdoor spaces of the beautiful retreat center, like a large lake and creek.

Jun 2 – 9

R855 ZAR per night

Guest favorite

Boutique hotel in Waynesville

4.95 out of 5 average rating, 20 reviews

Cozy and Rustic Deluxe Suite 10

Escape to our charming 1-bed, 1-bath suite in a historic mountain lodge. The deluxe rooms are updated with modern amenites while maintaining the rustic cabin feel. Ideal for a couple seeking a mountain getaway near nature, hiking, and local delights - all within walking distance of the shops, restaurants, and breweries of downtown Waynesville. Furry's Lodge is a 17 room, boutique mountain lodge and only a 20-minute drive from some outdoor fun at Cataloochee Ski Area.

May 5 – 12

R1,137 ZAR per night

Guest favorite

Nature lodge in Sylva

5.0 out of 5 average rating, 34 reviews

Cabin Suite at the Dillsboro Inn

This cozy, one-room efficiency has a large stone fireplace and private deck. Our Riverfront Inn is on a whitewater river with sights and sounds of flowing immediately in front of each suite. We have nightly campfires and are within walking distance to our town's fine dining options and craft shops. Our region has some of the finest eco-tourism opportunities in the eastern US and our neighborhood is ' Where the Blue Ridge Mountains meets the Smokies '.

Jul 19 – 26

R2,455 ZAR per night

Guest favorite

Room in Irmo

5.0 out of 5 average rating, 10 reviews

Relax in beach themed room.

You’ll love the stylish decor of this charming place to stay. Hot tub outside, pool is closed for winter. I do have 2 small dogs, but they won't be in your room. Very clean home and nicely decorated. my pups are scared of strangers and will run from you. PLEASE NOTE: SHAMPOO, CONDITIONER, TOOTHPASTE, SOAP AND DEODORANT ARE NOT PROVIDED, PLEASE BRING YOUR OWN.

Sep 30 – Oct 7

R1,235 ZAR per night

Guest favorite

Boutique hotel in Cashiers

4.88 out of 5 average rating, 244 reviews

King Room at our Boutique Bed & Brewery

Our King Room, located in the heart of Cashiers, North Carolina, is the perfect base camp for your mountain adventure! Whether you prefer to explore the beauty of the surrounding area or would rather explore a few locally crafted brews from our on-site brewery, Whiteside Brewing Co., we guarantee this room will cure what “ales” you. ;) Come dwell with us!

Dec 30 – Jan 6

R3,215 ZAR per night

Hotel room in South Carolina

4.74 out of 5 average rating, 172 reviews

Furnished King Apt Nightly Brand New Facility

500+ Sq. Feet Suites With a Dedicated Living Room, Full Kitchen and Separate Bedroom From enjoying your morning coffee and breakfast in the kitchen to walking down the hall and getting ready for the day in the bedroom and separate bathroom, we’ve created an environment where guests can go about their day as if they were at home and not a hotel.

Jan 8 – 15

R18,479 ZAR per night

Superhost

Boutique hotel in Waynesville

4.65 out of 5 average rating, 23 reviews

Cozy and Rustic Mountain Lodge Private Suite 1

Escape to our charming 1-bed, 1-bath suite in a historic mountain lodge. Old-world stone walls and timber beams meet stylish modernity in this cozy retreat. Ideal for a couple seeking a mountain getaway near nature, hiking, and local delights—all within walking distance to shops, restaurants, and breweries in downtown Waynesville!

Jun 7 – 14

R2,326 ZAR per night

Superhost

Resort in Etowah

4.76 out of 5 average rating, 51 reviews

Standard Room at Etowah Valley Golf and Resort

Etowah Valley Golf and Resort offers pristine golf course views, low prices, accommodations, and legendary service. We strive to offer guests a great and memorable experience, as well as close proximity to Asheville, Brevard, Hendersonville, and DuPont State Forest. Catering and facility rentals available upon request.

Sep 15 – 22

R2,043 ZAR per night

Guest favorite

Hotel in Clemson

5.0 out of 5 average rating, 17 reviews

The Abernathy

The Abernathy is located one block from The Rock and offers guests large rooms with 445 sq. ft. to stretch out and enjoy their stay in Clemson. Bicycles are available for guests to take on a leisurely pedal through Clemson's campus at their own pace. There is also an on-site bar to enjoy after a long day of exploring.

Feb 9 – 16

R3,123 ZAR per night