Hotel vacation rentals in Panama City

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Panama City

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Superhost

A spacious room features a king bed with soft white linens and colorful striped accent pillows. The headboard is constructed from light wood, complementing the contemporary design. A view of the city skyline is visible in the artwork above the bed, enhancing the room's ambiance.

Hotel room in Panamá

4.82 out of 5 average rating, 11 reviews

Very Nice Downtown Panamá Hotel Free Parking

Welcome to the beautiful Aloft Panamá hotel This is a very nice and safe hotel located in the San Francisco area of Panamá with beautiful city views. King or 2 queen based on availability (Feel free to make request prior to booking if you have a preference) All rooms non smoking ($350 fine) No pets allowed Must be 21 with id to checkin Must have credit card for incidentals Checkin time starts at 3pm Checkout time before noon Free Parking Pool Bar/Lounge

Superhost

An outdoor terrace features several lounge chairs and tables shaded by large umbrellas. A swimming pool extends along one side, with a backdrop of modern high-rise buildings under a partly cloudy sky. Lush greenery is present in planters, adding a touch of nature.

Hotel room in Marbella

4.83 out of 5 average rating, 6 reviews

En el corazón de la ciudad.

Hotel Mio Panamá somos un hotel 4 estrellas situado en la ciudad de Panamá, en el corazón del área financiera. Nuestro principal objetivo es satisfacer cualquier necesidad del cliente, ofreciendo los mejores servicios para garantizar una estancia cómoda y tranquila. Entre nuestras modernas instalaciones, encontrará una piscina, habitaciones amplias y cómodas, gimnasio, salas de reuniones y rooftop. Si le gusta viajar con su mascota, somos pet friendly.

A cozy hotel room is showcased with a spacious bed dressed in white linens and a red throw blanket. A wooden desk with two cups and a remote is positioned beside the bed. A soft lamp and a wall-mounted TV complete the inviting atmosphere.

Hotel room in El Cangrejo

4.71 out of 5 average rating, 31 reviews

Cuarto de hotel #3 a una cuadra del Metro.

Disfruta de acceso ràpido a los destinos más populares de Ciudad de Panamà, centros comerciales, restaurantes, y áreas turísticas. Cuarto de hotel con baño privado, aire acondicionado, cable TV, recepciòn con 24 horas de servicio y estacionamientos sujetos a disponibilidad. Cerca de restaurantes y casinos. A una cuadra de la estaciòn del Metro que lo lleva en 10 minutos a Albrook Mall, el Centro Comercial más grande de Panamà.

Guest favorite

A close-up view of vibrant purple bougainvillea flowers is presented alongside a well-maintained pathway, leading to a charming building with arched windows and a wooden front door. Green foliage frames the entrance, enhancing the welcoming atmosphere.

Hotel room in Panamá

4.86 out of 5 average rating, 43 reviews

Habitaciones privadas Sofia's B&B Hostal Boutique

Alojamiento tipo hostal boutique, contamos con 7 cómodas habitaciones privadas con baño, para una capacidad total de 18 huéspedes. La tarifa mostrada por Airbnb para tu reserva distribuye 2 huéspedes por habitación, es decir, los huéspedes deberan compartir camas y/o habitaciones. Si requieres una distribución especial de habitaciones para tu grupo, contacta primero con el anfitrión, ya que la tarifa podría variar.

Guest favorite

A rustic house is nestled among lush greenery, featuring a terracotta roof and large windows that allow natural light. A birdhouse hangs on a nearby tree, adding a touch of charm to the serene outdoor setting, complemented by a small pond and vibrant plants.

Private room in Panamá

5 out of 5 average rating, 19 reviews

Mandalas Ecolodge, Altos de Cerro Azul

Mandalas es un lugar para hacer senderismo, arte terapia , meditar, compartir en familia de ríos cascadas , miradores , actividades al aire libre, clima frío agradable, fauna y flora diversa, tomar vino en la noches nubladas, cerca de la ciudad y lejos de bullicio , solo la naturaleza y tu en un bosque nublado y lluvioso con lugares mágicos para descubrir cosas hermosas que nos da el universo privada y único.

Private room in Panamá

5 out of 5 average rating, 4 reviews

Casa Orquídea Ciudad de Panamá #1

Casa Orquídea es un Hermoso Residencial ubicado en el corazón de la ciudad de Panamá. Bienvenido a la joya de Paitilla rodeada de edificios, mar, y de una hermosa vegetación, esta casa es el secreto mejor guardado en una de las zonas más exclusivas de la ciudad, con espacios seguros para caminar. Este es el paraíso urbano para los amantes de la naturaleza. ¡Desconéctate y relájate en medio de la ciudad!

A tranquil pool area is surrounded by lush greenery, with palm trees and tropical plants creating a serene environment. Colorful circular seating stones are arranged near the edge of the pool, inviting relaxation. The pool's clear water reflects the sunlight, enhanced by the natural landscaping.

Private room in Panamá

4.64 out of 5 average rating, 47 reviews

El Canal

Welcome to CulturaHumana Living & Guest House, a sharing cultures house, a refuge, a place to stay, work and share smiles with people from all over the world.. Find a safe place to tour around the city, an oasis like garden right in the centre of the city, relaxed spot to work or share nice moments right by the pool garden, or simply best place to have dinner on a large shared set prepared exclusively.

Guest favorite

A cozy sleeping area features a plush bed with a light-colored quilt and dotted pillows. A bedside table holds a small lamp, providing soft lighting. The wall is adorned with a unique decorative panel, and a ceiling fan offers comfort.

Private room in Panamá

4.82 out of 5 average rating, 22 reviews

Desk & Dream Room

Disfruta de la comodidad de este alojamiento tranquilo y céntrico en el corazón de San Francisco, tiene escritorio dentro de la habitación para trabajar o estudiar en un ambiente relax, con las demás comodidades incluyendo televisor led HD de 32" Justo en la calle de al lado está el super mercado, farmacia al frente, restaurantes, tiendas de chinitos, panaderías, paradas del metro bus cercanas.

Superhost

Large green doors open to a charming balcony, revealing a view of a red-tiled roof and a small table with two chairs. A soft sofa is positioned nearby, complementing the inviting atmosphere of the space.

Hotel room in Panamá

4.86 out of 5 average rating, 105 reviews

Corcho rooms #2 - king room with balconies

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.

A welcoming exterior view of Serenade Lodging Rooms features a prominent sign amidst lush greenery and a well-maintained entrance. Stone accents enhance the modern façade, and a pathway leads to the building, providing easy access for guests.

Hotel room in Panamá

4.79 out of 5 average rating, 28 reviews

Serenade Lodging Rooms

Si necesitas un lugar donde te quieras sentir en casa fuera de tu casa, Serenade Lodging Rooms te lo ofrece.Habitaciones súper cómodas,con su cocineta incluida ... todo con los mejores estándares.. Desayuno completo incluido.. delicioso y variado.. y una excelente atención pues en Serenade Lodging Rooms usted es nuestra prioridad.