House vacation rentals in Panama City

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Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Panamá

4.94 out of 5 average rating, 36 reviews

Cantabria House - 10 minutes from the Airport

Spacious and comfortable home just 10 minutes from Tocumen Airport and only 200 meters from the Metro. Perfect for families, groups, or business trips. Fast 500 Mbps Wi-Fi, 3 bedrooms, 2 full bathrooms, fully equipped kitchen, air conditioning throughout the house, cable TV, patio with outdoor furniture, private parking, and self check-in. Long layover, family trip, or work in the city? This home has it all: comfort, location, and privacy. Book now and feel at home from the very first moment!

Top guest favorite

Home in Panama City

5 out of 5 average rating, 47 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Guest favorite

Home in Panamá

4.87 out of 5 average rating, 30 reviews

King Beds | 4BR | BBQ & Garden | pets ok!

Nestled in a prime central location, this lovely house offers guests unparalleled convenience and uniqueness. Find yourself just a swift 10-minute Uber ride away from the bustling heart of downtown, making exploration and nightlife easily accessible. One of the standout features of our home is the exclusive view of the Metropark, which you can relish from both the backyard and balcony – a serene panorama that's hard to beat. Finally sleep in supreme comfort with king-sized beds featured.

Guest favorite

Home in Punta Paitilla

4.76 out of 5 average rating, 97 reviews

Large Private Residence in an Excellent Area

House in the best areas of the country. Very quiet street, downtown, near restaurants, pharmacies, malls among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 Spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Opcion Kosher Disponible* House in one of the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall and more. Large comfortable residence for groups.

Guest favorite

Home in Panamá

4.87 out of 5 average rating, 15 reviews

Charming House in Casco Viejo

This recently renovated house is an absolute treasure. It blends history, charm, and modern comfort. Archeologists uncovered artifacts dating to the seventeenth century. Tastefully furnished with modern comforts and antiques, it's steps away from the Panama Canal Museum and in the heart of Casco Viejo, perfect for guests looking to immerse themselves in the cultural and culinary delights before retreating to the comfort and tranquility of their temporary home.

Guest favorite

Home in Panama City

4.93 out of 5 average rating, 14 reviews

A Charming Colonial House in Casco Antiguo

Welcome to Casa Arango, a beautifully restored 19th-century gem in the heart of Casco Antiguo. Located on a quiet, picturesque street, this colonial house blends historic charm with modern comforts. Casa Arango offers three elegant rooms with private bathrooms, a front balcony, and a spacious patio with a barbecue and private bar. Perfect for families or groups of up to 8, the property also includes two private parking spaces—an exclusive luxury in the area.

Guest favorite

Home in Panamá

4.87 out of 5 average rating, 38 reviews

Wonderful nature

Enjoy a family retreat in the heart of nature, where tranquility envelops you. This cozy accommodation, surrounded by a beautiful garden in the Metropolitan Natural Park, offers you a unique escape just 3 minutes from Albrook Mall and 5 minutes from downtown. Wake up to birdsong and a visit from the ñeques (agoutis), while relaxing in an exclusive and lively atmosphere. The perfect getaway to disconnect and enjoy nature with all the amenities!

Top guest favorite

Home in Panama City

4.8 out of 5 average rating, 107 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Top guest favorite

Home in Panamá

4.89 out of 5 average rating, 18 reviews

Entire house, pool table, jacuzzi, private rooftop

¡Bienvenido a Casa Compadre, tu hogar ideal en el histórico Casco Viejo de Panamá! Esta espaciosa y elegante casa cuenta con 4 cómodas habitaciones y capacidad para hasta 10 personas. Perfecta para grupos o familias, ofrece una sala de billar para el entretenimiento, espacios bien decorados y todas las comodidades para una estancia inolvidable. Disfruta de una estadía inolvidable en un ambiente acogedor y completamente equipado.

Guest favorite

Home in Panamá

4.93 out of 5 average rating, 124 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favorite

Home in Panamá

4.93 out of 5 average rating, 370 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Guest favorite

Home in Panamá

4.92 out of 5 average rating, 154 reviews

Golden Space | By Paradox

PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.