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House vacation rentals in Panama

Find and book unique houses on Airbnb

Top-rated house rentals in Panama

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Home in Bajo Boquete

4.81 out of 5 average rating, 110 reviews

Secluded Riverfront Home - Boquete area with Pool

Rio Escondido is located in the Boquete District near the town of Caldera. This incredible home rests on a bluff overlooking the Chiriqui Nuevo River. The river is about 400 meters from the house. The property is about 30 minutes from the cities of Boquete and David and the town of Caldera is only 5 minutes away. The house has everything you can ask for in a true vacation getaway and the property is a nature lovers dream. Rio Escondido is also a model of Off-Grid living as we are 100% Solar.

May 10 – 17

R1,486 ZAR per night

Home in Bocas del Toro District

4.93 out of 5 average rating, 191 reviews

Orange House - Over The Water Rentals

Enjoy golden sunsets across the bay from the Orange House at Over The Water Rentals. Home away from home in a tropical paradise. Relax on your outdoor lounge or explore the bay. The house has snorkel gear, SUP's & kayaks for guests to use for free. Bikes can be rented. Located close to town & airport in a quiet local neighborhood. The house features a king size master bedroom & queen guest room, spacious hot water shower, handmade organic toiletries, fully equipped kitchen & high speed wifi

Mar 9 – 16

R2,717 ZAR per night

Home in Pedasí

4.94 out of 5 average rating, 112 reviews

3 min to Pedasi, 5 min to the Beach, Private Pool!

Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Aug 17 – 24

R2,004 ZAR per night

Home in Costa Esmeralda

4.96 out of 5 average rating, 105 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sand! Come relax with the whole family at this piece of paradise. Majestic Sand is located in a private beach community in Costa Esmeralda, San Carlos District, Panama. It is located a few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, Santa Clara and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool with multiple hammocks with views of amazing palm trees.

Dec 19 – 26

R3,892 ZAR per night

Home in Taboga Island

4.96 out of 5 average rating, 140 reviews

Casa Rosie - Taboga dream home

Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Jan 8 – 15

R4,556 ZAR per night

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 196 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Aug 6 – 13

R6,020 ZAR per night

Home in Playa Venao

4.9 out of 5 average rating, 115 reviews

Beautiful Home Directly on Playa Venao Sleeps 8-10

This is our personal home and we take good care to make sure you thoroughly enjoy your stay! This home is located on the best surfing beach in the entire country. Walk out of your back door onto the sandy beach filled with wildlife and the best beach break for beginners to pros. This home offers luxury accommodations. This home is for families and respectful renters only. We do not accept groups who want to use the home to party.

Feb 18 – 25

R12,248 ZAR per night

Home in El Valle de Antón

4.93 out of 5 average rating, 117 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Aug 3 – 10

R2,180 ZAR per night

Home in Vista Mar Golf, Beach & Marina

4.88 out of 5 average rating, 224 reviews

Luxurious Beach House - Private Pool Golf & Marina

Vista Mar Golf, Beach & Marina is a gated community with private security, with direct access to a state of the art golf course designed by J. Michael Poellot. It also has marina, heliport, tennis courts, direct private beach access, bars and restaurants. The house comes with an outdoor private pool & hot tub, also a amazing private outdoor kitchen, and an amazing sea view with spectacular sunrises and sunsets.

Jul 28 – Aug 4

R13,245 ZAR per night

Home in Altos del Maria

4.78 out of 5 average rating, 238 reviews

Modern House in Altos del Maria, Panama

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. It´s a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains.

Aug 22 – 29

R5,127 ZAR per night

Home in Palmira

4.94 out of 5 average rating, 143 reviews

Hacienda Belina - private coffee farm experience

Hacienda Belina is our private family owned coffee farm located in the beautiful mountains of northwestern Panama just on the outskirts of the town of Boquete. My parents live on the property and together we operate this small Hacienda designed to attract avid travelers who are looking for a clean, comfortable, quiet, carefully decorated and authentic place to stay.

Sep 13 – 20

R1,827 ZAR per night

Home in Panamá

4.93 out of 5 average rating, 294 reviews

Private Studio 10 Min from the airport !

Entero Apartment 10 MINUTES FROM the Airport! We make sure to create this space with all the comforts to ensure a peaceful stay. The apartment is fully furnished including appliances and kitchen items, toiletries , dining room, work table and so on. Just minutes walk from SAN ANTONIO METRO Station, restaurants, shopping malls,laundries,supermarkets and pharmacies.

Jun 5 – 12

R790 ZAR per night

Vacation rentals for every style

Get the amount of space that is right for you

Cabins

Kick off your hiking boots at these rustic lodgings

Villas

Luxurious estates for the ultimate escape

Chalets

Adventure-ready homes with après-ski style

Popular amenities for Panama house rentals

Free parking on premises

Air conditioning

House rentals with a pool

Home in Panama

4.96 out of 5 average rating, 138 reviews

Villa Isabella in Coronado Beach Panama

Sep 24 – Oct 1

R6,025 ZAR per night

Home in contadora

4.85 out of 5 average rating, 191 reviews

villa in counter, pearls

Oct 1 – 8

R2,541 ZAR per night

Home in Playa Mata Oscura

4.92 out of 5 average rating, 24 reviews

Casa De Ola, Jungle Beach Cabin

Aug 12 – 19

R3,525 ZAR per night

Home in Panama City

4.88 out of 5 average rating, 25 reviews

Beautiful house with private pool

Aug 7 – 14

R2,478 ZAR per night

Home in Playa Venao

5.0 out of 5 average rating, 15 reviews

Casa Samambaia - sea view tropical paradise w pool

Jun 7 – 14

R5,113 ZAR per night

Home in San Carlos

4.93 out of 5 average rating, 87 reviews

Beach House-Ocean View Rooftop Jacuzzi & Pool

Jul 30 – Aug 6

R5,120 ZAR per night

Home in Playa Bluff

5.0 out of 5 average rating, 15 reviews

Jungle House 100m from the beach

Apr 24 – May 1

R6,327 ZAR per night

Home in Gamboa

4.86 out of 5 average rating, 88 reviews

BirdHouse@ Gamboa Panamá Canal

Aug 4 – 11

R7,005 ZAR per night

Weekly house rentals

Home in Los Algarrobos

4.99 out of 5 average rating, 118 reviews

New house! 5 min from David on the Boquete highway

Aug 29 – Sep 5

R1,390 ZAR per night

Home in Paso Ancho

4.87 out of 5 average rating, 130 reviews

Vista El Baru - Volcan, Paso Ancho, Panama

Mar 24 – 31

R1,446 ZAR per night

Home in Bocas del Toro

5.0 out of 5 average rating, 9 reviews

La Casita Barrbra BnB

Jun 21 – 28

R4,025 ZAR per night

Home in Boquete

5.0 out of 5 average rating, 63 reviews

Alba Verde Guest House, Private Vacation Rental

Jul 28 – Aug 4

R2,640 ZAR per night

Home in Santa Catalina

5.0 out of 5 average rating, 24 reviews

Casa Colibrí - modern house in the green

Jun 29 – Jul 6

R2,644 ZAR per night

Home in Boquete

5.0 out of 5 average rating, 12 reviews

Caturra Casita @ Finca Panda

Sep 5 – 12

R5,888 ZAR per night

Home in Corregimiento de Isla Grande

4.96 out of 5 average rating, 83 reviews

Puntita Manzanillo, fantastic sea and jungle

Mar 3 – 10

R10,048 ZAR per night

Home in Torio

5.0 out of 5 average rating, 13 reviews

Ideal Creative Retreat Immersed in Forest

Nov 29 – Dec 6

R2,031 ZAR per night

Private house rentals

Home in Boca Chicá

5.0 out of 5 average rating, 22 reviews

Entire house with private pool facing beach !

Mar 5 – 12

R3,402 ZAR per night

Home in Bastimento

4.84 out of 5 average rating, 44 reviews

Bay Of The Floating Palms - Beach Front Home

Jun 11 – 18

R5,371 ZAR per night

Home in Bocas del Toro

5.0 out of 5 average rating, 21 reviews

Tropical Paradise, Oceanfront Home in the Jungle

Dec 25 – Jan 1

R10,072 ZAR per night

Home in Chame

4.92 out of 5 average rating, 12 reviews

Escape the city! Cozy weather and home.

Jan 17 – 24

R2,751 ZAR per night

Home in Panamá

5.0 out of 5 average rating, 5 reviews

Unique 4 room house - direct access to the beach

Mar 11 – 18

R16,695 ZAR per night

Home in Bajo Boquete

4.96 out of 5 average rating, 56 reviews

Spacious 3BR walking distance, close to everything

Aug 10 – 17

R2,572 ZAR per night

Home in Nueva Gorgona

5.0 out of 5 average rating, 26 reviews

Cozy beachfront cottage

May 5 – 12

R2,330 ZAR per night

Home in Cacique

5.0 out of 5 average rating, 18 reviews

El Paraiso

Nov 15 – 22

R5,484 ZAR per night

Destinations to explore