Mansion vacation rentals in Panama

Find and book unique mansions on Airbnb

Top-rated mansion rentals in Panama

Guests agree: these mansions are highly rated for location, cleanliness, and more.

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Superhost

Home in Bastimentos Island

4.82 out of 5 average rating, 126 reviews

Spacious, Over the Water Home with Plunge Pool

Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.

Guest favorite

Condo in Buenaventura, El Chirú

4.97 out of 5 average rating, 125 reviews

Stylish & Quiet ~ Breathtaking Laguna Views ~Pool

➡️ The highest rated w more than 60 reviews! ⬅️ Welcome to "The Gliding Damselfly," the MOST stylish 4BR 4Bath flat nestled in the majestic Buenaventura, perfect for escaping city crowds and enjoying mesmerizing views, stunning beaches (5 mins), and lavish pools (2 mins). Explore the area and its exciting attractions, and then retreat to the breathtaking sanctuary that will leave you in awe. ✔ 4 Comfy BRs ✔ Open Design Living ✔ Full Kitchen ✔ Terrace ✔ Smart TVs ✔ Fast Wi-Fi See more below!

Guest favorite

A spacious living area with a light-colored sofa is paired with a dining table, accommodating multiple chairs. Large windows provide unobstructed views of the beach and ocean, allowing natural light to fill the space. Decorative mirrors enhance the modern ambiance.

Apartment in Maria Chiquita

4.96 out of 5 average rating, 107 reviews

Spacious 4Br Beachside Getaway at Playa Escondida

Escape to Playa Escondida Resort & Marina for the ultimate luxury getaway. Our 4Br beachfront apartment is ideal for families and friends seeking relaxation in the Caribbean Sea. Indulge in plush rooms, white sand beaches, and unforgettable sunsets. Our fully equipped apartment provides everything you need for an exceptional stay, and our unparalleled service ensures you'll never want to leave. Best of all, it's just an hour away from Panama City. Book now for a truly unforgettable experience.

Guest favorite

The modern house is set against a backdrop of rolling mountains, illuminated by the soft glow of evening light. A spacious entrance is visible, with large sliding doors opening to inviting communal areas. Lush greenery surrounds the property, enhancing its natural appeal.

Earthen home in El Cope, Penonome

4.92 out of 5 average rating, 177 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

Guest favorite

An aerial view captures the tranquil shoreline, with a stretch of black sand beach meeting the calm turquoise waters. Lush greenery and scattered residential areas are visible alongside the coast. Cloud formations drift above, suggesting a pleasant coastal climate.

Home in San Carlos

4.95 out of 5 average rating, 122 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base price covers 4 guests (additional charge $40 per person). Sleeps up to 25 guests.

Top guest favorite

Villa in Punta Chame

4.97 out of 5 average rating, 125 reviews

Beach House with Pool/Gazebo in Punta Chame!

"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Superhost

An outdoor space is illuminated at night, featuring a private pool surrounded by lush greenery. A tall palm tree stands prominently near the edge, with a spacious patio area that includes an open structure providing shade. Calm blue lighting reflects off the water's surface.

Home in Vista Mar Golf, Beach & Marina

4.88 out of 5 average rating, 251 reviews

Luxurious Beach House - Private Pool Golf & Marina

Vista Mar Golf, Beach & Marina is a gated community with private security, with direct access to a state of the art golf course designed by J. Michael Poellot. It also has marina, heliport, tennis courts, direct private beach access, bars and restaurants. The house comes with an outdoor private pool & hot tub, also a amazing private outdoor kitchen, and an amazing sea view with spectacular sunrises and sunsets. any inquiry please contact 66168596

Top guest favorite

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 211 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Top guest favorite

A shaded lounge area features a wooden sofa adorned with colorful cushions, situated under a corrugated roof. Soft lighting fixtures hang above, illuminating the space. Lush, green foliage surrounds the area, creating a serene atmosphere in the beautifully landscaped garden.

Home in El Valle de Antón

4.95 out of 5 average rating, 154 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Guest favorite

An inviting infinity pool is positioned on a spacious patio, overlooking a sweeping mountain view. Two lounge chairs are arranged on the deck, facing the water, while lush greenery and colorful blooms enhance the serene environment surrounding the pool area.

Cottage in Altos del Maria

4.94 out of 5 average rating, 147 reviews

Mountain Cottage with Great View and Heated Pool

Mountain Cottage, with spectacular views of the Altos del María Mountains, perfect for relaxing or spending time with the family. It features a heated pool, spacious outdoor spaces, Smart TV and A/C in all rooms and living room, Wi-Fi throughout the property, and is fully equipped. Includes Prime Video service. It also has a fire pit and a gas BBQ. Complimentary late checkout is available for rentals departing on Sundays.

Guest favorite

The open living area features comfortable seating arrangements, with a mix of sofas and wooden chairs. Large glass doors invite natural light in, providing a view of the private swimming pool and garden. Decorative artwork adorns the walls, enhancing the space.

Villa in Farallon

4.91 out of 5 average rating, 223 reviews

4-Bedroom Costa Blanca Golf & Beach Villa

Spacious 4 bedroom, 4.5 bathroom, 250m detached villa overlooking the 7th putting green on Mantaraya Golf Course. Accommodation provided for up to 12 people within 4 bedrooms. The 15m long swimming pool plus shallow area in rear garden is totally private. Villa guests have access to the Property Owners Beach Club and Restaurant.

Guest favorite

Condo in Buenaventura, El Chirú

4.92 out of 5 average rating, 130 reviews

Modern | Steps to Beach Club & Shops | Sleeps 10

★ A Proper Rents Experience ★ • Beautiful design • Excellent location • Steps to the La Mansa Beach Club! • Spacious & luxurious • Luxury Bedding • 75 inches TV • Beautiful views! • Half a block from restaurants & convenience store! • Fully equipped • High speed internet • Buenaventura, best luxury beach resort in Panama