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Villa vacation rentals in Panama City

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Popular amenities for Panama City villa rentals

Private villa rentals

Guest favorite
Villa in Punta Pacifica
4.98 out of 5 average rating, 82 reviews

Beautiful House in Panama w/ King Beds + Pool

ZackRating, 5 stars3 weeks ago
5 Stars – Great Stay! Our group of 8 had an amazing time at Jonathan’s place. The home was spacious, clean, and perfectly set up for a group our size. The location couldn’t have been better — just a 1-minute walk to two grocery stores, excellent coffee shops, and a variety of restaurants. Jonathan was an outstanding host — extremely responsive and helpful as a few needs came up during our stay. He handled everything quickly and made sure we were comfortable the entire time. Would absolutely recommend this home to anyone visiting Panama!
A serene pool area is surrounded by lush tropical foliage, creating a secluded atmosphere. Several lounge chairs are positioned around the pool, while a few individuals enjoy the water. The clear water reflects the green surroundings, enhancing the tranquil vibe of the space.
Villa in Panama
4.67 out of 5 average rating, 3 reviews

La Semilla | Jungle Mansion | Panama City

MariaRating, 5 stars53 months ago
David is an excellent host who was looking forward to us being well. He gave us hiking tips. Maria is an excellent cook, we didn't meet the days to try all the dishes. What we liked the most is that the place is truly pet friendly because there is no difference of races or sizes. We were able to go with all of our pets.
Villa in Panamá
4.81 out of 5 average rating, 53 reviews

Villa La Vista-Panama's majestic mountain hideaway

DarienRating, 5 stars2 weeks ago
Amazing place with a beautiful view of Panama City. We enjoyed our stay and would definitely come back again next time we are in Panama.
The exterior of a charming villa is displayed, featuring a wooden structure with green windows and doors. A vibrant yellow accent wall highlights the entrance, framed by lush greenery and stone steps leading to the front porch.
Villa in Panamá
4.5 out of 5 average rating, 6 reviews

In the Last Place in the World (6 guests)

LuigyRating, 5 stars26 months ago
A place and a house that would unquestionably come back and recommend. The house is cozy, the weather is perfect, the divine pool... in the end what it takes to spend a few days totally relaxed.
Top guest favorite
A cozy bedroom features a spacious bed with a patterned coverlet, complemented by a bedside table and a lamp. A wardrobe is positioned nearby, and curtain panels frame the window, allowing natural light to filter in. The minimalist decor creates a serene atmosphere.
Villa in Panamá
5 out of 5 average rating, 13 reviews

Villa Helena Studio 1 Apt Cerro Azul

KhaleelRating, 5 stars3 months ago
Very Very super great host will fully recommend 💯 percent great location nice clean surroundings lovely pool ,beautiful scenery thank you ms Helen for taking care of me and my wife looking forward to doing it again you are a wonderful person keep up the good work 👏 🙌
Superhost
A private pool area features a large swimming pool and a smaller hot tub, surrounded by lush greenery. Potted plants and tropical foliage enhance the setting, while a lounge chair is positioned beside the pool. The space is framed by a charming stone wall and an elegant railing.
Villa in Panamá
5 out of 5 average rating, 5 reviews

Villa Helena 2 Bedrooms Cerro Azul

AlexRating, 5 stars6 months ago
The stay was nothing but awesome, Ms Helen energy is absolutely amazing and her place outstanding, would definitely recommend , I felt right at home, I would definitely come back
Top guest favorite
A multi-story mansion is showcased overlooking a vibrant swimming pool, adorned with inflatable toys including a pink flamingo and a whale. Bright umbrellas provide shade over red loungers, all set against a backdrop of lush greenery and a partially cloudy sky.
Villa in Panamá
4.98 out of 5 average rating, 54 reviews

Breathtaking Views Mansion w/King Beds

MelissaRating, 5 stars1 week ago
The home is breathtaking and the host was so gracious. When we arrived, we were met by Dario who welcomed us and gave us a tour. There are four floors of amazing space and you feel like you are in a palace. We enjoyed the pool, media room, and billiard room and were surprised to see the mini-golf on the 4th floor. There are patios everywhere and the views are stunning. There are plenty of supplies for cooking and the dining room comfortably seats 8. We highly recommend this home, and we hope to return. Thank you Bradley and Dario for a fabulous experience!!
The villa is surrounded by greenery, featuring a two-story structure with distinctive architectural elements. A well-maintained lawn extends in front of the house, while a stone pathway leads to the entrance. Various plants and trees provide a natural setting.
Villa in Panamá
4 out of 5 average rating, 5 reviews

Tranquility and peace connect with Nature 🌤

IlianisRating, 5 stars9 months ago
We felt right at home. And Juan Pablo the best always attentive and very thoughtful with everything. We will definitely be back The house is highly organized and clean. I recommend the full to spend their family days and with friends. They will want to stay many more days like us. I repeat it, we will definitely be back

Luxury villa rentals

Top guest favorite
A multi-story mansion is showcased overlooking a vibrant swimming pool, adorned with inflatable toys including a pink flamingo and a whale. Bright umbrellas provide shade over red loungers, all set against a backdrop of lush greenery and a partially cloudy sky.
Villa in Panamá
4.98 out of 5 average rating, 54 reviews

Breathtaking Views Mansion w/King Beds

MelissaRating, 5 stars1 week ago
The home is breathtaking and the host was so gracious. When we arrived, we were met by Dario who welcomed us and gave us a tour. There are four floors of amazing space and you feel like you are in a palace. We enjoyed the pool, media room, and billiard room and were surprised to see the mini-golf on the 4th floor. There are patios everywhere and the views are stunning. There are plenty of supplies for cooking and the dining room comfortably seats 8. We highly recommend this home, and we hope to return. Thank you Bradley and Dario for a fabulous experience!!
Top guest favorite
A modern outdoor area features a turquoise swimming pool surrounded by lush greenery. The space includes a partially covered patio with seating options and an outdoor bar area. Tall buildings are visible in the background against a clear blue sky.
Villa in Punta Pacifica
5 out of 5 average rating, 16 reviews

5BR House in Panama City w/ Pool & King Beds

NatashaRating, 5 stars1 week ago
The home was very comfortable and clean. Jonathan was very communicative and quick to respond to needs and questions. The only suggestion I have is to maybe have 2 bottles of water waiting for your guests. Other than that , everything was good!
Guest favorite
Villa in Punta Pacifica
4.98 out of 5 average rating, 82 reviews

Beautiful House in Panama w/ King Beds + Pool

ZackRating, 5 stars3 weeks ago
5 Stars – Great Stay! Our group of 8 had an amazing time at Jonathan’s place. The home was spacious, clean, and perfectly set up for a group our size. The location couldn’t have been better — just a 1-minute walk to two grocery stores, excellent coffee shops, and a variety of restaurants. Jonathan was an outstanding host — extremely responsive and helpful as a few needs came up during our stay. He handled everything quickly and made sure we were comfortable the entire time. Would absolutely recommend this home to anyone visiting Panama!
A serene pool area is surrounded by lush tropical foliage, creating a secluded atmosphere. Several lounge chairs are positioned around the pool, while a few individuals enjoy the water. The clear water reflects the green surroundings, enhancing the tranquil vibe of the space.
Villa in Panama
4.67 out of 5 average rating, 3 reviews

La Semilla | Jungle Mansion | Panama City

MariaRating, 5 stars53 months ago
David is an excellent host who was looking forward to us being well. He gave us hiking tips. Maria is an excellent cook, we didn't meet the days to try all the dishes. What we liked the most is that the place is truly pet friendly because there is no difference of races or sizes. We were able to go with all of our pets.

Villa rentals with a pool

Guest favorite
Villa in Punta Pacifica
4.98 out of 5 average rating, 82 reviews

Beautiful House in Panama w/ King Beds + Pool

ZackRating, 5 stars3 weeks ago
5 Stars – Great Stay! Our group of 8 had an amazing time at Jonathan’s place. The home was spacious, clean, and perfectly set up for a group our size. The location couldn’t have been better — just a 1-minute walk to two grocery stores, excellent coffee shops, and a variety of restaurants. Jonathan was an outstanding host — extremely responsive and helpful as a few needs came up during our stay. He handled everything quickly and made sure we were comfortable the entire time. Would absolutely recommend this home to anyone visiting Panama!
Villa in Panama
4.67 out of 5 average rating, 3 reviews

La Semilla | Jungle Mansion | Panama City

MariaRating, 5 stars53 months ago
David is an excellent host who was looking forward to us being well. He gave us hiking tips. Maria is an excellent cook, we didn't meet the days to try all the dishes. What we liked the most is that the place is truly pet friendly because there is no difference of races or sizes. We were able to go with all of our pets.
Villa in Panamá
4.81 out of 5 average rating, 53 reviews

Villa La Vista-Panama's majestic mountain hideaway

DarienRating, 5 stars2 weeks ago
Amazing place with a beautiful view of Panama City. We enjoyed our stay and would definitely come back again next time we are in Panama.
Villa in Panamá
4.5 out of 5 average rating, 6 reviews

In the Last Place in the World (6 guests)

LuigyRating, 5 stars26 months ago
A place and a house that would unquestionably come back and recommend. The house is cozy, the weather is perfect, the divine pool... in the end what it takes to spend a few days totally relaxed.
Top guest favorite
A cozy bedroom features a spacious bed with a patterned coverlet, complemented by a bedside table and a lamp. A wardrobe is positioned nearby, and curtain panels frame the window, allowing natural light to filter in. The minimalist decor creates a serene atmosphere.
Villa in Panamá
5 out of 5 average rating, 13 reviews

Villa Helena Studio 1 Apt Cerro Azul

KhaleelRating, 5 stars3 months ago
Very Very super great host will fully recommend 💯 percent great location nice clean surroundings lovely pool ,beautiful scenery thank you ms Helen for taking care of me and my wife looking forward to doing it again you are a wonderful person keep up the good work 👏 🙌
Superhost
A private pool area features a large swimming pool and a smaller hot tub, surrounded by lush greenery. Potted plants and tropical foliage enhance the setting, while a lounge chair is positioned beside the pool. The space is framed by a charming stone wall and an elegant railing.
Villa in Panamá
5 out of 5 average rating, 5 reviews

Villa Helena 2 Bedrooms Cerro Azul

AlexRating, 5 stars6 months ago
The stay was nothing but awesome, Ms Helen energy is absolutely amazing and her place outstanding, would definitely recommend , I felt right at home, I would definitely come back
Top guest favorite
A multi-story mansion is showcased overlooking a vibrant swimming pool, adorned with inflatable toys including a pink flamingo and a whale. Bright umbrellas provide shade over red loungers, all set against a backdrop of lush greenery and a partially cloudy sky.
Villa in Panamá
4.98 out of 5 average rating, 54 reviews

Breathtaking Views Mansion w/King Beds

MelissaRating, 5 stars1 week ago
The home is breathtaking and the host was so gracious. When we arrived, we were met by Dario who welcomed us and gave us a tour. There are four floors of amazing space and you feel like you are in a palace. We enjoyed the pool, media room, and billiard room and were surprised to see the mini-golf on the 4th floor. There are patios everywhere and the views are stunning. There are plenty of supplies for cooking and the dining room comfortably seats 8. We highly recommend this home, and we hope to return. Thank you Bradley and Dario for a fabulous experience!!
Top guest favorite
A modern outdoor area features a turquoise swimming pool surrounded by lush greenery. The space includes a partially covered patio with seating options and an outdoor bar area. Tall buildings are visible in the background against a clear blue sky.
Villa in Punta Pacifica
5 out of 5 average rating, 16 reviews

5BR House in Panama City w/ Pool & King Beds

NatashaRating, 5 stars1 week ago
The home was very comfortable and clean. Jonathan was very communicative and quick to respond to needs and questions. The only suggestion I have is to maybe have 2 bottles of water waiting for your guests. Other than that , everything was good!

Quick stats about villa rentals in Panama City

  • Total rentals

    10 properties

  • Nightly prices starting at

    R1,417 ZAR before taxes and fees

  • Total number of reviews

    370 reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with a pool

    10 properties have a pool

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City
  5. Villa rentals