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Hotel vacation rentals in Panama City

Find and book unique hotel rentals on Airbnb

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Vacation rentals for every style

Get the amount of space that is right for you

Popular amenities for Panama City hotel rentals

Kitchen
Wifi
Pool
Free parking on premises
Air conditioning

Family-friendly hotel rentals

A sleeping area features a spacious bed with a neutral-toned cover and a dark blue blanket folded at the foot. Simple wooden nightstands are mounted on either side, each equipped with bedside lighting. Soft natural light filters through a sheer curtain over a window.
Hotel room in Panamá
4.68 out of 5 average rating, 76 reviews

Your second home in Panama.

Superhost
A hotel room featuring two spacious beds with soft bedding, complemented by a gray accent wall. A desk and chair are positioned near the window. The door to the hallway is visible in the background, along with a flat-screen television mounted on the wall.
Hotel room in Marbella
4.4 out of 5 average rating, 5 reviews

Double Deluxe

The sleeping area features two beds with decorative blue and white patterned bedspreads. A bedside table holds a telephone. Natural light enters from the window, accompanied by light curtains and deep red drapes. The walls are finished in a neutral tone.
Hotel room in Panamá
4.74 out of 5 average rating, 81 reviews

Single Triple Family Room

A spacious room features a double bed with a soft white blanket and two towels neatly arranged. Bedside tables with lamps flank the bed, while a decorative wall with patterned design adds a unique touch. A wooden door leads to another area, enhancing privacy.
Hotel room in Panamá
4.68 out of 5 average rating, 357 reviews

Room with private bathroom in downtown Panama

A private pool is surrounded by lush greenery, providing a serene space for relaxation. Colorful round seating options are placed on the gravel path leading to the pool. A shaded area features a picnic table in the background, inviting social gatherings in a natural setting.
Private room in Panama City
4.67 out of 5 average rating, 78 reviews

The Bridge

A small sleeping area features light green walls and a cozy bed with a striped linen cover. A single window is partially draped with green curtains, allowing natural light to illuminate a potted plant positioned on the windowsill.
Private room in Panama City
4.67 out of 5 average rating, 12 reviews

El Tornillo semi-private space.

A spacious room is highlighted by a neatly made bed with a navy blue and white color scheme. A wooden desk and white chair are positioned nearby, offering a workspace. Soft light fills the room, and a door leads to a separate sleeping area in the background.
Hotel room in Panamá
4.55 out of 5 average rating, 103 reviews

Comfortable room with a private bathroom

An entrance area is framed by a modern black shelving unit displaying lush green plants. Vintage-style light bulbs hang from the ceiling, providing soft illumination. A tiled floor features intricate geometric patterns, while a staircase is visible in the background, leading to the upper levels.
Hotel room in Panamá
4.69 out of 5 average rating, 131 reviews

Panama City Center - Room with private bathroom

Hotel rentals with a pool

A spacious Jr Suite features a large bed adorned with colorful pillows, complemented by natural wood accents. A small wooden table and chairs are positioned nearby. A ceiling fan circulates air in the bright room, which is illuminated by a striking lamp and natural light from a doorway.
Hotel room in Panamá
4.25 out of 5 average rating, 4 reviews

Jr. Suite Rm #3 - Cerro Azul

Hotel room in Panamá
4.45 out of 5 average rating, 20 reviews

Rainforest Suite with Breakfast! 15 min from city

A well-appointed sleeping area is equipped with two spacious beds, each dressed in crisp white linens and topped with red accent blankets. Soft lighting is provided by wall-mounted lamps, and floor-to-ceiling curtains frame the window, adding privacy and warmth to the space.
Hotel room in El Cangrejo
4.77 out of 5 average rating, 13 reviews

Double Suite-Apartment Hotel Príncipe

Hotel room in Panamá
New place to stay

Double Deluxe with Balcony - Viajero Hostels

A tranquil pool area is surrounded by lush greenery, with palm trees and tropical plants creating a serene environment. Colorful circular seating stones are arranged near the edge of the pool, inviting relaxation. The pool's clear water reflects the sunlight, enhanced by the natural landscaping.
Private room in Panamá
4.64 out of 5 average rating, 47 reviews

The Canal

A cozy bedroom features a spacious bed dressed in a light blue quilt. Two bedside tables with soft lamps flank the bed, providing gentle illumination. A green accent wall and a piece of leaf-themed artwork add a touch of natural beauty to the room.
Hotel room in Panamá

Tropical Tranquility - Coconut Lodge

An outdoor swimming pool is situated on a rooftop terrace, surrounded by lounge chairs. The skyline of Panama City serves as a backdrop, illuminated by soft twilight hues. Palm plants are placed in decorative pots along the pool's edge, enhancing the space.
Hotel room in Obarrio

Marinn Place | Deluxe King | Cozy Work & Rest

A well-lit bedroom features a spacious bed with neutral-toned bedding. Two bedside lamps provide soft lighting, while a small nightstand holds essentials. A window allows natural light to enter, and the minimalist decor emphasizes a calm ambiance.
Hotel room in Panamá
3.8 out of 5 average rating, 5 reviews

Hotel Room with one full bed

Hotel rentals with a patio

A spacious sleeping area features a four-poster bed dressed in neutral linens, accented by a vibrant red pillow. A comfortable red couch is positioned near large glass doors, which provide natural light and views of the surrounding greenery.
Private room in Panamá
4.75 out of 5 average rating, 4 reviews

Harpy Eagle Room in Treehouse

Lush greenery surrounds the entrance, featuring hanging plants and colorful decorations. Ferns cascade from hanging baskets, creating a vibrant and inviting entrance to the hostal.
Private room in Gamboa
4 out of 5 average rating, 4 reviews

Nice hostel, ideal for family trips.

A calming bedroom features a spacious bed adorned with soft linens. A large wall art piece depicting a serene face adds depth to the navy-blue walls. Natural light filters through draped curtains, and two decorative lamps provide gentle illumination beside the bed.
Hotel room in Panama City
4.67 out of 5 average rating, 3 reviews

Suite Room in the ORHO Hotel

A compact sleeping area is enclosed within wooden panels, featuring a spacious bed with freshly laundered linens. A soft towel is neatly rolled on the bed. Warm lighting and minimalist design contribute to a tranquil atmosphere.
Shared room in Panamá
4.67 out of 5 average rating, 6 reviews

Shared Mixed Bedroom 1

A spacious guestroom features wood-paneled walls and a ceiling fan. Two beds are positioned against a light-toned wall. Natural light enters through large windows with beige shades. A closet and a small work area with a mirror are also included, enhancing the room's functionality.
Private room in Panamá
3.8 out of 5 average rating, 5 reviews

Kakún Room 12, Cable TV, Refrigerator, Air Conditioning.

A modern room features a spacious bed with neutral bedding, complemented by a light-colored accent wall. A small dining table with two chairs is positioned near a floor-to-ceiling window, which is framed by soft curtains. A flat-screen TV is mounted on the opposite wall.
Hotel room in Panamá
5 out of 5 average rating, 3 reviews

Eshel Panama Suites, Atlantic suite 04

A spacious bedroom is presented with a large bed, complemented by soft pillows and a neutral bedspread. A small circular table with two upholstered chairs is positioned nearby. A large window allows natural light to fill the room, enhancing the warm red wall.
Hotel room in Panamá

Excellent private room

Superhost
The bright sleeping area features two double beds with stylish headboards and decorative accent pillows. A textured area rug is placed on the hardwood floor. Natural light floods the room through large windows with sheer curtains, complementing the exposed brick wall.
Hotel room in Panamá

Charming Studio w Two Double Beds

Quick stats about hotel rentals in Panama City

  • Total rentals

    120 properties

  • Nightly prices starting at

    R176 ZAR before taxes and fees

  • Total number of reviews

    3.2K reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    20 properties allow pets

  • Rentals with a pool

    30 properties have a pool

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City
  5. Hotel rentals