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Hotel vacation rentals in Panama City

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Vacation rentals for every style

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Popular amenities for Panama City hotel rentals

Kitchen
Wifi
Pool
Free parking on premises
Air conditioning

Family-friendly hotel rentals

Superhost
A wooden sign displays the text 'Tanti Familiar' in elegant script, surrounded by delicate white flowers. The natural grain of the wood is visible, contributing to a warm and inviting look.
Private room in Santa Cruz De Chinina
4.8 out of 5 average rating, 51 reviews

Tanti 2, room in house on beachfront terrain

The entrance of El Bongo Boutique Hotel is framed by lush greenery and vines, leading to a stone pathway that guides visitors to the reception area. The building features a two-story structure with wooden accents and large windows, inviting natural light into the space.
Hotel room in Portobelo

Beachfront Boutique Hotel and Restaurant Portobelo

A spacious bed is presented with white bedding and decorative green pillows. Two rolled towels are neatly placed at the foot of the bed. Natural light filters into the room through two windows, adorned with sheer curtains and dark drapes, alongside a small nightstand with a floral arrangement.
Private room in Panamá
4.25 out of 5 average rating, 4 reviews

Hostal Villa Grande - Room 4

Superhost
An open-air space is shown featuring wooden flooring and a high, sloped ceiling. Seating is provided by cozy wicker chairs surrounding a table. A bedroom area is visible in the background, with large windows allowing natural light and views of greenery.
Hotel room in Santa Cruz De Chinina
4.67 out of 5 average rating, 3 reviews

Tanti 1, a room in a house with beach access

A view of the property’s landscaped garden leads to the beach, with sandy ground and palm trees swaying in the breeze. A patio with seating is visible, while the ocean stretches out in the background, framed by lush greenery and a clear sky.
Hotel room in Santa Cruz De Chinina
5 out of 5 average rating, 9 reviews

Pink Palace Panama

Superhost
A vibrant yellow building is visible amidst lush greenery, complemented by a clear blue sky. Colorful umbrellas shade the outdoor seating area around a turquoise pool, featuring wooden decking and various chairs. Tropical plants add to the natural surroundings.
Private room in Taboga Island
5 out of 5 average rating, 5 reviews

Eco Lodge Mango Room 3 Queen Plus

Top guest favorite
A serene river flows gently surrounded by lush greenery and trees. Smooth rocks are partially submerged in the water, creating a tranquil natural setting. Clear reflections of the surrounding foliage can be seen on the surface, enhancing the peaceful ambiance of the area.
Private room in Panamá
4.99 out of 5 average rating, 104 reviews

Casa Momote Loma Limon

Superhost
A bright pink flamingo float is positioned in a refreshing plunge pool. Lush greenery surrounds the area, with a terracotta pot featuring a leafy plant in the foreground. The ocean view and cloudy sky are visible in the background.
Private room in Taboga Island
4.89 out of 5 average rating, 63 reviews

Eco Lodge Garden Room 5 Oceanview Plunge Pool

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Hotel rentals with a pool

A spacious Jr Suite features a large bed adorned with colorful pillows, complemented by natural wood accents. A small wooden table and chairs are positioned nearby. A ceiling fan circulates air in the bright room, which is illuminated by a striking lamp and natural light from a doorway.
Hotel room in Panamá
4.25 out of 5 average rating, 4 reviews

Jr. Suite Rm #3 - Cerro Azul

A well-appointed sleeping area is equipped with two spacious beds, each dressed in crisp white linens and topped with red accent blankets. Soft lighting is provided by wall-mounted lamps, and floor-to-ceiling curtains frame the window, adding privacy and warmth to the space.
Hotel room in El Cangrejo
4.77 out of 5 average rating, 13 reviews

Double Suite-Apartment Hotel Príncipe

The room features two neatly made single beds dressed in soft beige bedding, placed side by side. A window provides natural light, complemented by a wall-mounted light fixture. The modern floor is tiled in a light gray finish, contributing to a minimalist aesthetic.
Hotel room in Panamá
3.89 out of 5 average rating, 9 reviews

Private room 2 twin beds

A spacious bedroom is presented with a large bed, complemented by soft pillows and a neutral bedspread. A small circular table with two upholstered chairs is positioned nearby. A large window allows natural light to fill the room, enhancing the warm red wall.
Hotel room in Panamá

Excellent private room

A modern room features a spacious bed with crisp white linens, paired with a dark blue throw. Large windows provide a city view, and a desk with a chair is positioned against the wall. Soft lighting is provided by a wall-mounted lamp.
Hotel room in Obarrio

Room in the City

A private pool is surrounded by lush greenery, providing a serene space for relaxation. Colorful round seating options are placed on the gravel path leading to the pool. A shaded area features a picnic table in the background, inviting social gatherings in a natural setting.
Private room in Panama City
4.67 out of 5 average rating, 76 reviews

The Bridge

A cozy bedroom features a spacious bed dressed in a light blue quilt. Two bedside tables with soft lamps flank the bed, providing gentle illumination. A green accent wall and a piece of leaf-themed artwork add a touch of natural beauty to the room.
Hotel room in Panamá

Tropical Tranquility - Coconut Lodge

An outdoor swimming pool is situated on a rooftop terrace, surrounded by lounge chairs. The skyline of Panama City serves as a backdrop, illuminated by soft twilight hues. Palm plants are placed in decorative pots along the pool's edge, enhancing the space.
Hotel room in Obarrio

Marinn Place | Deluxe King | Cozy Work & Rest

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Hotel rentals with a patio

A spacious sleeping area features a four-poster bed dressed in neutral linens, accented by a vibrant red pillow. A comfortable red couch is positioned near large glass doors, which provide natural light and views of the surrounding greenery.
Private room in Panamá
4.75 out of 5 average rating, 4 reviews

Harpy Eagle Room in Treehouse

An aerial view captures a serene pool nestled among lush greenery. Two vibrant pink floats rest on the water's surface, surrounded by tropical plants and palm trees. A wooden deck extends around the pool, enhancing the natural setting.
Private room in Chilibre

LILI: Tropical Bungalow with Monkeys, Pool & Yoga

A compact room is shown with a twin-size bed dressed in a light-colored quilt. An air conditioning unit is mounted above, and a window is adorned with sheer blinds, allowing soft light to enter. A small shelf is positioned beside the bed, featuring two levels for storage or decor.
Hotel room in Panamá

Single | Private | Hostel Room

Lush greenery surrounds the entrance, featuring hanging plants and colorful decorations. Ferns cascade from hanging baskets, creating a vibrant and inviting entrance to the hostal.
Private room in Gamboa
4 out of 5 average rating, 3 reviews

Nice hostel, ideal for family trips.

A spacious guestroom features wood-paneled walls and a ceiling fan. Two beds are positioned against a light-toned wall. Natural light enters through large windows with beige shades. A closet and a small work area with a mirror are also included, enhancing the room's functionality.
Private room in Panamá
3.8 out of 5 average rating, 5 reviews

Kakún Room 12, Cable TV, Refrigerator, Air Conditioning.

Superhost
A comfortable sleeping area features a spacious bed with dark bedding and decorative pillows. Soft natural light enters through a pair of floor-to-ceiling curtains. Exposed brick walls create texture, complemented by wooden bedside tables and a compact seating area.
Hotel room in Panamá

Charming Studio w King Bed

A modern room features a spacious bed with neutral bedding, complemented by a light-colored accent wall. A small dining table with two chairs is positioned near a floor-to-ceiling window, which is framed by soft curtains. A flat-screen TV is mounted on the opposite wall.
Hotel room in Santa Cruz De Chinina
5 out of 5 average rating, 3 reviews

Eshel Panama Suites, Atlantic suite 04

The three-story building features a modern architectural design with a light pink façade. Multiple large windows allow natural light to fill the interior, while the entrance is framed by a decorative metal gate and covered porch.
Private room in Panama City
New place to stay

Mansión Moderna

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Quick stats about hotel rentals in Panama City

  • Total rentals

    120 properties

  • Nightly prices starting at

    R176 ZAR before taxes and fees

  • Total number of reviews

    3.2K reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    20 properties allow pets

  • Rentals with a pool

    30 properties have a pool

Destinations to explore

  1. Airbnb
  2. Panama
  3. Panamá Province
  4. Panama City
  5. Hotel rentals