House vacation rentals in Rochester

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Top-rated house rentals in Rochester

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Top guest favorite

A cozy living area features a patterned sofa with a red accent pillow, complemented by warm wooden flooring. A brick wall provides texture, and natural light filters through the windows. In the background, a dining area with a wooden table and chairs can be seen, along with a staircase.

Home in Rochester

4.98 out of 5 average rating, 104 reviews

Cottage in Lowertown–Perfect for Mayo & Downtown

In Lowertown-this quaint cottage with modern updates is your home away from home! Fully furnished and a well stocked kitchen make it a wonderful place for overnight stays or longer term rentals. Beautiful patio provides an urban sanctuary at the end of a long day. Close proximity to Mayo Clinic-downtown restaurants, grocery stores and shopping are within walking distance. Two blocks in either direction puts you on the trail system. Public transit 1 ½ blocks away and a laundromat is ½ block away.

Top guest favorite

A bright living room features a large window with sheer curtains allowing natural light. A comfortable gray sofa is paired with a black recliner and a glass coffee table, complemented by a patterned area rug and decorative wall art.

Home in Rochester

4.99 out of 5 average rating, 158 reviews

NEW: Renovated rambler with ramp - no stairs!

• Enhanced cleaning protocols due to COVID • Main floor living w exterior ramp for easy access on Mayo Clinic stays • Fully renovated house in winter 2022 • 3 bedrooms w queen beds • Fully stocked kitchen w dishwasher, Keurig and k-cups • Main floor living room w sectional and smart TV • Huge basement w sectional, TV, kids toys • Free garage & driveway parking • High-speed wifi for work/streaming • Central AC & furnace w thermostat you control • Main floor bath tub & lower level walk in shower

Top guest favorite

An open-concept living area features a comfortable seating arrangement with a coffee table, set upon a striped rug. A ceiling fan and natural light from large windows enhance the space. The kitchen, visible in the background, showcases modern appliances and bar seating.

Home in Rochester

4.97 out of 5 average rating, 231 reviews

☆Oakley's Oasis: A Dharma Dwellings Designed Home☆

Oakley's Oasis is named after our beloved first puppy. Much like him, the house has a lot of personality, and is named to honor his legacy! Having lived in the home and loved the neighborhood with Silver Lake within walking distance and Mayo Clinic less than 10 minutes. The home is next door to our other homes, Poppy's Paradise and Dee Dee's Den. We have been blessed to host hundreds of guests, and work hard to ensure you have an relaxing and restorative experience with us at Dharma Dwellings!

Guest favorite

A cozy seating area features a gray sofa and two armchairs with decorative cushions. A round coffee table sits in the center, accompanied by a plush area rug. A large TV displays a calming nature scene, while soft natural light filters through sheer curtains.

Home in Rochester

4.92 out of 5 average rating, 250 reviews

Home Calls the Heart- 10min to Mayo

1/2 block from HWY 52, serene and peaceful split level home. 10 min to Mayo Clinic & St. Mary's Hospital. Fully furnished, convenient and ideal for families and professionals for the home away from home feel. Luxury Sheets & Posturepedic beds. Reasonable Mall of America drive. Fully equipped with various kitchen appliances and utensils. Minutes to parks, groceries, Walmart, Target etc. Wifi, Roku Smart TV & cable. Phone call away if you have any issues while staying at our charming home.

Top guest favorite

A cozy sleeping area is presented with a dark patterned bedspread, featuring a yellow accent pillow that reads 'be our guest.' Above the bed, a floral wall art piece with white flowers against a turquoise backdrop adds a refreshing touch to the space.

Home in Rochester

4.98 out of 5 average rating, 115 reviews

The Little House | 1 mi from downtown, Love Pets!

The Little House is the perfect place of you're looking for something Cozy, stylish, and close to everything that you need. This home was a fun renovation project for my husband and I. It's located in the family friendly Sunnyside Addition neighborhood and we've worked hard to make sure you have everything you need during your stay. This home has a beautiful fully fenced in yard with a neighborhood feel while still being less than a 5 minute drive from Downtown & Mayo Clinic Campuses!

Top guest favorite

A spacious living area features warm wood beam ceilings and large windows, allowing natural light to fill the room. Modern furniture, including a comfortable white sofa and a glass dining table, is arranged to create an inviting space. Double doors lead to a backyard patio.

Home in Rochester

4.95 out of 5 average rating, 241 reviews

Euro House, Bright! Near Mayo-Single Family Home

Welcome to our private single family home designed by local architect Harold Crawford, located in a quiet neighborhood close to the Mayo Clinic, parks, & restaurants. The backyard is a master gardeners dream space, filled with native plants & outdoor seating. 2 queen bedrooms & 2 full baths. Off street parking for 1 vehicle, plenty of street parking. Wi-Fi, cable, smart TV's, washer & dryer included. Pet free, Clean and Modern home away from home. 5 minutes / .9 miles from Mayo Clinic!

Guest favorite

Home in Rochester

4.87 out of 5 average rating, 347 reviews

Mayo Downtown's Prairie Home Retreat

Nestled in a serene corner, this home offers a perfect blend of tranquility and accessibility; being near the Mayo campus and Rochester's key attractions. Enjoy comfortable beds, a well-appointed kitchen, and a fenced yard with patio gardens. It's an excellent spot for family bonding, featuring three smart TVs, rapid Wi-Fi, and a variety of indoor and outdoor entertainment options. We strive to accommodate flexible check-in/check-out arrangements whenever feasible. Rollator accessible.

Top guest favorite

A spacious bedroom is furnished with a neatly made bed featuring a grid-patterned duvet and various accent pillows. Light-colored walls are complemented by a workspace visible through open doors, enhancing functionality within the room.

Home in Rochester

4.97 out of 5 average rating, 124 reviews

Charming 3BR family home - 8 min drive to Mayo

Your home away from home. Cozy 3 BR, 4 bed, 1.5 bath home located centrally in Rochester. Approximately 2 miles from Mayo & St. Mary’s hospital, 700 ft to nearest small grocery store, 0.6 miles to nearest gas station, and 1.5 miles to nearest shopping area w/Target, Chipotle, Applebee’s & more. Close to the Bus lines, bike trails & parks. This home is in the center of the city and is easily accessible. Come home and relax in a quiet, quaint neighborhood. All bedrooms on top floor.

Top guest favorite

The exterior of the home features a welcoming entrance with a porch, adorned with an American flag. The driveway leads to an attached garage, and landscaped green areas surround the entrance, creating an inviting approach.

Home in Rochester

5 out of 5 average rating, 127 reviews

Convenient, comfortable rambler near Mayo Clinic

• 1 mile to Saint Marys hospital and Mayo Clinic (Gonda) • Main level living — one 1 step up to front door • King bed, queen bed and daybed • Attached garage — huge perk in Minnesnowta! • Smart TVs w sectionals on main floor & basement, smart TV mounted in primary bedroom and a Roku TV in the queen size bedroom. • Two work spaces • Walk-in shower with grab bar • Serene rear patio with gas grill • Quiet neighborhood near Soldiers Field park, Apache Mall and biking/walking trails

Top guest favorite

The open-concept living area showcases vaulted ceilings and skylights, enhancing natural light. Two light grey sofas frame a wooden coffee table on a colorful area rug. A dining area with a large table and chairs is visible, with stairs leading to the upper level in the background.

Home in Rochester

4.97 out of 5 average rating, 173 reviews

Spacious Modern Home Near Mayo, St. Mary's Campus

- 5 min walk to Mayo Clinic, St. Mary’s campus - 3 bedrooms, 3 bathrooms, and a loft - unique design with vaulted ceiling and skylights in the style of Frank Lloyd Wright, one of its kind in the whole neighborhood - two-car garage + another dedicated parking space outside - walkable and safe family-friendly neighborhood close to downtown and all amenities - outside front and back patios - fusball play table - dedicated workspace - high speed wifi - Apple TVs - washer and dryer

Top guest favorite

The living area is highlighted by a modern gray sofa, accentuated with textured cushions. A sleek coffee table holds a glass vase with greenery, while art pieces adorn the wall. Natural light filters through sheer curtains, creating a bright and inviting space.

Home in Rochester

4.96 out of 5 average rating, 115 reviews

Entire Boutique Home Kutzky Park ★ Walk to Mayo ★

Welcome to Asfar house! Expertly designed and centrally-located in a desirable Kutzky Park neighborhood, walking distance to Mayo Clinic, restaurants and shops. Whether you are relocating or visiting Rochester, this house will be sure to impress. Blasting fast WIFI, 3 relaxing bedrooms & a fully equipped kitchen. A perfect retreat to enjoy the coffee bar, read, watch a Netflix episode, play and relax. Enjoy the perfect shower, conveniently adjoined with free washer and dryer.

Top guest favorite

A bright bedroom features a spacious bed with white linens and a decorative pillow. A bedside lamp emits soft light beside a window with light curtains. A green dresser and a mirror complement the neutral walls, adding a fresh touch to the space.

Home in Rochester

4.98 out of 5 average rating, 345 reviews

The Guesthouse Cottage, walkable to Mayo Clinic

Our Guesthouse has a clean cottage feel. The king and queen bedrooms offer closets and quality linens. Cook meals in a fully stocked kitchen. Book an Uber, or walk 0.6 miles to Mayo's main Gonda building. We're close to grocers, coffee, parks and trails, and downtown's restaurants, shops, and a lovely public library. Free washer and dryer on site. Google TV and internet. 3-season porch. Small guest garage. No smoking on the property.