Lake house vacation rentals in Santee

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Top-rated lake house rentals in Santee

Guests agree: these lake houses are highly rated for location, cleanliness, and more.

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Guest favorite

A vibrant garden filled with blooming orange and yellow flowers creates a colorful border. Green grass stretches out toward a marina, where boats are docked. Sunlight filters through trees, casting light and shadows on the yard, which features picnic tables and recreational seating.

Home in Lake Murray

4.87 out of 5 average rating, 176 reviews

Lake Murray Paradise~2 BR, 1 Bth, Kit/Living area.

Enjoy the full lake adventure with 4 kayaks included. Our property is a lake front paradise w/ about 1 acre on Lake Murray near the dam on the Lexington side of the lake. Close to Columbia, USC and Ft. Jackson. 3 Decks, 1 dock, hot tub & fire pit w/ wood. Private upper deck to the 2 Bedroom, 1 Bath suite with Open Kitchen, Living & Game Area w/ large flat screen TVs, Pool, Ping Pong & Foosball table. The entire upstairs is your private area w/ views of the lake. We offer boat tours. Fees apply.

Guest favorite

The exterior of the lakefront cottage features a green and brick facade, complemented by a red bench on the porch. A circular concrete path leads to the entrance, while surrounding greenery and trees add to the natural setting. Soft evening light enhances the inviting atmosphere.

Home in Manning

4.88 out of 5 average rating, 65 reviews

Cozy Church Branch Cabin

A cozy lakefront cottage made by family, for family. This was our parents home away from home, their favorite getaway. Now that they're gone, we want to share what they enjoyed. Traditionally constructed lake cabin with all the comforts of home. Large partially covered deck, large pier for fishing, plenty of room to bring your boat, canoes, or kayaks. Extremely close proximity to large landings where national fishing tournaments are held on Lake Marion. Prime hunting, near great hunting clubs.

Guest favorite

A serene view of Lake Marion at sunset, with vibrant hues reflecting on the water. A wooden dock extends into the lake, surrounded by lush greenery. The soft contours of the shoreline are visible, creating a peaceful natural setting.

Home in Santee

4.91 out of 5 average rating, 66 reviews

Lakefront Lookout

The best panoramic views of Lake Marion! Whether you're out on the porch or indoors in our air-conditioned unit, you will not miss out on the beauty of the lake. Our updated kitchen and two full bathrooms are stocked with all the essentials. Hop on a boat, swim in the community pool, fish, walk, run, or bike the pedestrian bridge, or just hang out with your company while watching the boats go by. Please respect the fact that there is a small pet fee and we’re alerted when pets are present.

Top guest favorite

A view of the serene lake is framed by vibrant pink flowers in the foreground. The gently sloping lawn leads to a wooden dock that extends over the water, with a covered boat slip visible in the background. A peaceful atmosphere is conveyed through the lush green space.

Home in Manning

5 out of 5 average rating, 14 reviews

Lakefront vacation….bam!

Escape to this peaceful 3 bed 2 bath waterfront retreat on beautiful Lake Marion. Perfect for relaxation and adventure! Enjoy world class bass fishing, swimming, boating and watersports right from your own private ramp and dock. Golf courses are also nearby. Challenge friends to a game of badmitton or croquet, or enjoy a bbq on the charcoal grill. This freshly updated home features new flooring and a fresh coat of paint.There also is a fish cleaning station, Wifi and new washer and dryer!

Guest favorite

The spacious screened-in porch features comfortable seating, a circular table, and ceiling fans. Soft lighting enhances the area, with panoramic views of Lake Marion visible through large screens. Vibrant sunset colors are seen in the sky, reflecting off the water in the background.

Home in Summerton

4.94 out of 5 average rating, 169 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Guest favorite

A scenic view of the lake is presented, featuring a long dock extending into the calm water. Lush greenery and palm trees frame the foreground, while a faint rainbow appears in the backdrop under a partly cloudy sky.

Home in Santee

4.96 out of 5 average rating, 170 reviews

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

Guest favorite

A spacious house is positioned near the edge of a calm lake. A wooden dock extends into the water, with a walking path leading to the home. The outdoor area features a deck with seating and landscaping including trees and shrubs.

Home in Lake Murray

4.87 out of 5 average rating, 114 reviews

Lakefront w pool, dock and pool table, sleeps12

Location, location, location! 10 minutes to Lexington, 15 minutes to Chapin, 15 minutes to downtown Columbia, 8 minutes to Harbison shopping. Boat parking at the dock. No need to pay high docking fees. Gorgeous sunsets, calm cove. Swim in the lake or relax by the pool. The massive deck is great for family fun or unforgettable events with your friends. Close to Liberty’s /Lake Murray marina on the lake, and Cat Fish Johnnys/rusty anchor marina. Not your typical Lake Murray Airbnb!

Top guest favorite

An aerial view captures the lakeside property surrounded by lush greenery and mature trees. The mobile home sits adjacent to the water, featuring a landscaped yard and access to a private boat launch. Nearby structures and pathways are also visible.

Home in Cross

5 out of 5 average rating, 34 reviews

Fish Haven

Looking for a quiet, yet charming lakeside property? Look no further! Come enjoy this three-bedroom home with direct access to the diversion canal and a private boat launch. Great space for fisherman, families or couples. Ample space for your boat and hitch. Enjoy your days fishing, savor your afternoon by having a beverage and grilling out on the back patio. Spend the evenings playing cornhole and relaxing by the fire pit. It is the perfect setting to create wonderful memories!

Guest favorite

A spacious wooden deck features a round glass table surrounded by four chairs, with an umbrella providing shade. Leaves are scattered across the surface, and greenery from the surrounding trees creates a natural backdrop.

Home in Earlewood

4.93 out of 5 average rating, 138 reviews

KING Beds - Bungalow Downtown Cola

* KING Beds in both bedrooms * PET FRIENDLY * EV CHARGER PLUG (4 Prong outlet ONLY, no cord or adapter) * TVs in both bedrooms and living room * 1.4 miles from PRISMA Hospital (4-minute drive) * BLACKOUT CURTAINS in all the bedrooms * 15 minutes to Fort Jackson * 7 minutes to Riverbanks Zoo * 5 minutes to the Columbia Museum of Art and Soda City Market * HUGE Deck with table and small covered area * Off-street parking pad for 5+ cars * 11-minute drive to Lexington Medical Center

Guest favorite

The exterior of the home is showcased, highlighting a charming façade with a mix of brick and siding. Large windows reflect natural light, and the welcoming porch features seating. A landscaped yard and tall trees provide a serene backdrop, complementing the overall inviting atmosphere.

Home in Summerton

4.83 out of 5 average rating, 111 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

Guest favorite

The exterior of the home features a modern architectural design with large windows and a spacious deck. An inviting infinity pool is illuminated, reflecting the colorful sunset. A comfortable outdoor seating area surrounds a fire pit, creating a serene lakeside atmosphere.

Home in Summerton

4.92 out of 5 average rating, 123 reviews

Ultimate Lake Marion Dream Home W/Pool & Swim Spa

Welcome to The White House—a stunning lakefront retreat on Lake Marion. This luxurious home features 4 spacious bedrooms, 3.5 baths, a chef’s kitchen, private dock, gas grill, and HDTVs throughout. Relax in the infinity pool or unwind in the swim spa as you take in the tranquil views. The master suite is a true sanctuary, offering unmatched comfort and elegance. Hosted by Lake Marion Luxury Vacations, this home is your gateway to peace, luxury, and unforgettable memories.

Guest favorite

A spacious outdoor area features a large grassy lawn, a swimming pool, and an enclosed porch. A shaded pavilion with seating stands nearby. The home showcases a blend of modern design and natural surroundings, creating an inviting setting for relaxation and outdoor activities.

Home in Summerton

4.95 out of 5 average rating, 19 reviews

Lake House Retreat

Newly renovated home directly on the big waters of Lake Marion with beautiful open water views and direct lake access. Large open concept interior, a brand-new enclosed back porch. Outdoor kitchen & shower and a gorgeous swimming beach. Park your boat or fish from the dock, kayak down the beach and through the cove, or relax on your own private beach for endless hours of summer fun. Huge backyard for outdoor games with a pool and spa. It's a perfect retreat!