
Pet-friendly vacation rentals in Santee
Find and book unique pet-friendly homes on Airbnb
Top-rated pet-friendly home rentals in Santee
Guests agree: these pet-friendly homes are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Santee pet-friendly home rentals
Pet-friendly home rentals with a hot tub

Home The On Hill - Near Everything Charleston!
Everything was exactly as described and the location was FANTASTIC for traveling with small kids. Tamra & Lisa were great communicators ahead of and during our stay, even welcoming us with wine and cheese. Everything was comfortable and the pack n play & high chair on site were a great bonus. The kitchen is fully, full equipped if you like to do some cooking at “home” like we do. There are some fragile items at curious tot level but the living areas are child friendly. Absolutely recommend these hosts and this stay!

The Herons Nest
This home worked great for us and our extended family during our son's graduation. Everything was clean and well appointed.

Lakefront Paradise W/Pool/hot tub/outdoor kitchen
This was an absolutely beautiful property! Comfortable, inviting and we loved the game room!! Arriving you are greeted by a gorgeous front yard and and even more impressive backyard with the lake right beyond the fenced in new pool! Wonderful place to make memories. I would recommend!

LakeMurray-Pool-HotTub-GameRm-Beach-FirepitPlaySet
Can’t say enough good things about the place. My kids had a blast (almost 6 and 8). When i say they loved it, the LOVED it. The TV “room” upstairs is to die for. Must be a 100 inch tv on the wall. The pool is amazing, hot tub, pool table for the adults, awesome dock (neighbors that can deliver a boat for rent right next door - also super friendly) and great little arcade game set up (my son became quite infatuated with the golf game). Bonus to get to bring my pup who also enjoyed. Truly can’t say enough good things about this place. Plenty of beds (especially if your spouse leaves his CPAP at home). Could easily fit 2 families of 4/5 very comfortably. 10/10. Kids were ready to move.

Best of Both Worlds with Beautiful Back-Yard Oasis
It was really clean and smelled nice. he also provided a lot of towels which was nice. everything worked how expected and the property is beautiful.

Lake Moultrie retreat
Amazing stay. The host Marcus was amazing and very considerate. The place itself was clean and in a great location. Highly recommend.

Hot Tub• Pac-Man•3 Kings•Smart TVs• WiFi • W/D •
The house was spotless, fun, and stocked with everything we needed! It rained the entire time we were in Charleston so I was glad we had an Airbnb with lots of activities (shuffleboard, arcade games, board games, and a hot tub). The three kiddos in the house never got bored. The train noise took some getting used to but we blasted white noise and it was fine. I will say…I would not have been comfortable staying in that neighborhood without my husband/other adults. I did not even feel comfy walking the dog by myself during the day. There was foot traffic from unhoused folks and people going back and forth to the liquor store across the train tracks. That being said, the price was right and it was one of few places in the area that would allow our doggie. My husband and the other baseball dad we traveled with were completely unbothered by the surroundings. The windows and doors locked securely and privacy curtains were on every window. Plus close to nice parks and lots of food options

Luxury RV Campsite Site #2 with Hot Tub
Spent one day and night at this beautiful location. Would definitely stay again!!! Everything was very well maintained and absolutely breathtaking. We enjoyed a fun walk and fishing, the firepit/grill was easy to use, the landscaping transported us to an oasis, the hot tub was very clean and made for a wonderful wind down after dinner! The bathhouse and outside shower were very clean and so relaxing! I could have easily stayed another week, and can't wait to return!
Pet-friendly home rentals with a pool

SullyChic 5 Bedroom | Private Lux Pool Park Circl
Everything I hoped and wished for our stay was like the pictures and details! It was a gorgeous home, the bedrooms were comfy and spacious. The kitchen was massive and so perfect for a big group, the backyard with the pool was so beautiful and like a little oasis! It was the perfect distance to downtown, not too far. Such a good stay, definitely will be back!

Park Circle retreat with King Bed Suite
This house was perfect for our family and our dogs. It was super clean and had everything we needed and more! The park within walking distance was awesome too. I would definitely stay here again!

Blue Bungalow- 22 min to beach with huge yard
Very well stocked with towels, kitchen and cleaning supplies! Would recommend

Camden Cottage
This was my second stay at the cottage. It's very comfortable and has everything you need - including a well-equipped kitchen. It's easy to find, very quiet, and dog-friendly. Kathryn and Greg are good communicators and very responsive. Highly recommend and will stay there again in the future if available.

Dream River House at North Charleston
This might be the best vacation rental we have ever had. My grandson liked this vacation more than Disney World. It was the perfect place to relax and just enjoy being with family. Mark was great and available if we had any questions. We will definitely be coming back.

Family Friendly House in Charleston’s Park Circle
Beautiful place, extremely responsive and well worth the stay!

Walk to restaurants, 10min to Chas and Beaches!
The pictures accurately represented her space. We found there was plenty of room for four adults. The kitchen was well stocked with pots and pans, silverware and dishes, something we find to not always be the case. The location was ideal for visiting the beaches and getting to Charleston. Megan was good at making sure we had all the prearrival information we needed and had recommendations on what to do and where to eat. If we were in the area we would stay here again.

Pear Tree Farm-pets welcome! Stables/paddocks too!
We were there for a girl’s get away and it was perfect. It rained the entire time we were there but it didn’t spoil our time together. There are so many spaces to be cozy and enjoy time together. Just a short drive into Camden or stay on the farm the entire time. Would definitely recommend and hope to get back again! Thanks David for a wonderful get away!
Pet-friendly house rentals

ROOST. Pet friendly, Clean, Quiet, Comfortable.
We had a great stay at Michelle's Airbnb. Michael was very helpful with whatever we needed in our 3+ week stay. Thanks for a comfortable and clean place to stay!

Santee/Lizzie's Creek Lakefront
The house was as advertised. It was right on the lake. The dock had a beautiful view of the lake. The house was well maintained and looked like the pictures. The showers were a little tight, but overall the house was great. Will definitely stay here again on our next trip down to Lake Marion.

Lakehouse
Beautiful get away spot! Perfect location for the boat ramp.

New! Lakefront Hideaway | Peaceful & Serene
Ashley was a great host and the house has everything you need for a relaxing getaway or a good fishing trip! We came in town for a few days fishing and it was perfect for our stay. Very easy to get to boat ramps, and to get around Cross area. Beds are comfortable and everything has been updated and very homey feeling.

Kuker Cottage Downtown Florence-Near I95 & I20
Great place to stop in for the night.

Almost Heaven on Lake Marion, SC
Spacious and comfortable for our group of 6. The kitchen was well equipped for our needs, the back porch had lovely view of the river and was large, breezy, and comfortable with fans. The beds were comfortable with fresh soft linens. Audrey was very responsive to questions but everything worked and we had no issues during our stay.

Lake Moultrie, Lake front with private dock
Kellie’s place was as amazing as I remembered. This was our 2nd time renting her beautiful lake house & it did not disappoint. The property is so serene & peaceful.

Farmhouse Living near DT, USC, Ft. Jackson! Pets!
The stay was perfect. The home is in a great location, being convenient to lots of things to do while also far enough away from main roads where it is quiet at night.
Destinations to explore
- Hilton Head Island Vacation rentals
- Augusta Vacation rentals
- Columbia Vacation rentals
- Folly Beach Vacation rentals
- Mount Pleasant Vacation rentals
- Isle of Palms Vacation rentals
- Atlanta Vacation rentals
- Gatlinburg Vacation rentals
- Charleston Vacation rentals
- Western North Carolina Vacation rentals
- Myrtle Beach Vacation rentals
- Charlotte Vacation rentals
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom