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Guesthouse vacation rentals in Mission Bay, San Diego

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Mission Bay, San Diego

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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A modern living area features a spacious sectional sofa with decorative pillows, accompanied by a marble top coffee table. A bright kitchenette is visible, equipped with stainless steel appliances. Natural light streams through multiple windows, leading to an outdoor space with a view.

Guesthouse in Bay Park

4.96 out of 5 average rating, 363 reviews

Private Guesthouse with Bay View Deck

The one bedroom, one bath unit was recently remodeled (in 2017) and includes all new kitchen, bathroom, full size laundry and air conditioning. The large 400 square foot private deck has new outdoor furniture with views of Mission Bay and gorgeous sunsets year round. Enjoy a show on the 50" 4K LG smart TV in the living room which offers Netflix, Amazon Video, and major network TV stations. Cook a delicious meal in the kitchenette complete with a mini-fridge/freezer, microwave, electric stove top, coffeemaker, and more. If you plan to head to the beach, the storage ottoman is secretly a "beach box" containing a couple of folding chairs, beach toys, towels and a small cooler. The unit is stocked with coffee, shampoo, conditioner, laundry supplies, iron, and more. Filtered water is provided via a faucet on the kitchen sink. Easy check-in via a numeric keypad on the front door with the code provided prior to arrival. Plenty of street parking is available. We love meeting new people and live next door in the main house so we are available most anytime. We are both from San Diego and still love to explore the latest new spots so we are happy to give recommendations. Bay Park is a great central neighborhood originally built in the early 1940s. It was recently voted the most livable neighborhood in a recent San Diego poll. Check out the restaurants on Morena Boulevard, which are just a few minutes' walk away or explore all of the major attractions of San Diego easily. The house has easy access to I-5 and is only 10-15 mins from downtown, Sea World, the San Diego Zoo and the airport. The private guest house is located across from Mission Bay and within walking distance to bay, market, restaurants and coffee shops. Uber/Lyft is $8 to $14 to most of San Diego's main attractions. There is a bit of white noise from the highway down the hill near Mission Bay when out on the deck but nothing too bad, just worthy of mention. The unit has double paned vinyl windows so it's quiet indoors.

Top guest favorite

A curving staircase is visible, flanked by white walls and adorned with vibrant blue tiles. Handrails provide support along the ascent, leading to a bright upper space. A potted plant enhances the serene ambiance at the top of the stairs.

Guesthouse in Mission Hills

5 out of 5 average rating, 196 reviews

Santorini-Inspired Cottage w/ Hot Tub + Views

*CHECK OUT OUR OTHER AIRBNB* Travel 16 steps up a Greek-inspired curving stairway with 2-story high walls to your tucked-away cottage built into the hillside villa of Alta Colina. With spectacular views, step onto the balcony to watch planes take off & boats sail around the harbor. End the night in front of your secluded back patio fireplace or climb the steps of your spiral staircase to the rooftop Jacuzzi. European-inspired design & details, it'll be hard to believe you’re still in San Diego!

Top guest favorite

A broad view captures the coastal landscape of La Jolla, featuring the shimmering ocean, serene bay, and city lights under a clear sky. The horizon displays the iconic pier, with the vibrant residential area blended into the backdrop of rolling hills.

Guesthouse in La Jolla

4.98 out of 5 average rating, 215 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

Welcome to your private 1,000 sq. ft. studio apartment, atop a scenic hill in La Jolla. Enjoy views of the ocean, bay, city lights and Sea World fire works display, creating the perfect backdrop for your getaway. Conveniently located just 5 minutes from the beautiful Windansea Beach and only 8 minutes from the vibrant village of La Jolla, where you can explore shops, dining, and cultural attractions. Experience the best of San Diego, with top attractions just minutes away. Your ideal getaway

A welcoming entrance features red brick steps leading up to a solid wooden door, framed by dark wooden beams. Lush greenery and potted plants accentuate the pathway, while large windows on either side provide natural light to the area.

Guesthouse in San Diego

4.95 out of 5 average rating, 491 reviews

Modern Sweet Home Stay, Hillcrest, A/C Parking W/D

This quaint bungalow sits in a prime location of Hillcrest, a highly desirable area in San Diego. It is very quiet and private and sits directly behind our house(pictured) with a beautifully landscaped brick courtyard. You are within walking distance to "The Heart of Hillcrest" where you will discover many fabulous restaurants, coffee and boutique shops, and so much more. We are a short Uber drive to downtown and everywhere else San Diego has to offer. We hope you stay with us soon!

Top guest favorite

A welcoming open-concept living area is visible, featuring a gray sofa and two light blue armchairs. A marble coffee table sits in the center. Large windows allow natural light to flow in, displaying serene views of the surrounding landscape.

Guesthouse in Ocean Beach

4.97 out of 5 average rating, 100 reviews

Breathtaking Ocean Views-Sunset Cliffs/Ocean Beach

Experience our stylish second story 1BR/1.5BA guesthouse with ocean, city, and mountain views in Point Loma. Perfect for couples, solo adventurers, and business travelers, this family-managed retreat offers a welcoming open-concept living space, equipped modern kitchen, and a tranquil bedroom with multiple balconies. 5 blocks from the ocean, it's the perfect coastal escape. Explore San Diego's attractions, including Old Town, Gaslamp, & Balboa Park. Book now for an unforgettable stay.

Natural light fills the airy sleeping area, featuring a spacious queen-size bed and cozy seating. French doors open to a serene view of the tree-filled canyon, while large windows ensure a bright atmosphere. A decorative plant adds a touch of freshness to the inviting space.

Guesthouse in Clairemont Mesa West

4.89 out of 5 average rating, 199 reviews

Serene San Diego Canyon Getaway

Our cozy studio-style guest house perched above a tree-filled canyon is a serene getaway in the center of San Diego, just a few minutes' drive to all local attractions and most of our other institutions (colleges, universities, hospitals). The casita is comfortable for two or a small family, with full kitchen capacity to prepare at-home meals. Our weather here is temperate, but if the weather gets hot, we have a silent mini-split A/C unit to cool the casita as needed.

Top guest favorite

The poolside area features a well-maintained saltwater pool reflecting the colors of the sunset. Comfortable seating arrangements, including lounge chairs and a cozy fire pit, are visible. Large umbrellas provide shade, and lush greenery adds to the serene ambiance.

Guesthouse in Lake Murray

4.96 out of 5 average rating, 116 reviews

Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV

This is the perfect Guest House with a salted & heated pool & hot tub. We are located in a super quiet & very safe neighborhood in beautiful San Diego, 15 minutes drive to Downtown, La Jolla, Beaches, Zoo, Sea World & Convention Center. Hike next door at Mission Trails & Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo and top quality finishes await you inside. Everything you need for memorable vacation! No smoking or vaping on the property.

A serene garden courtyard is depicted, featuring two wooden chairs adorned with floral cushions. A small table sits between the chairs on a grassy area, surrounded by lush greenery and climbing vines, creating a peaceful outdoor setting.

Guesthouse in Mission Hills

4.92 out of 5 average rating, 428 reviews

La Casita - Fully Updated Casita in Mission Hills

This well designed, fully updated detached studio casita is located in one of the most sought after neighborhoods in San Diego - Mission Hills. Surrounded by a serene garden courtyard with private entry and quiet patio. Close to great dining, grocery stores and shopping, and a mere 10 minutes or less to most of San Diego’s main attractions. If you are coming by car, there is plenty of free street parking - otherwise Ubers are plentiful and reasonably priced.

The living area features natural wood paneling and a warm color palette. Large windows allow ample light, framed by woven shades. A comfortable white sofa and a stylish entertainment unit with a television are visible, along with a decorative chair and a small side table.

Guesthouse in Mission Beach

4.9 out of 5 average rating, 749 reviews

South Mission Beach Zen-Like Studio

This fully furnished second story South Mission bayside studio offers relaxed beach living. This studio sleeps 2 (Queen Bed) & 2 Boogie Boards are provided; private off street parking on premise. Bbq grill on small balcony. The unit is steps to the bay and short three minute stroll to the beach. Two beach cruiser bicycles provided which is one great way to get around the area. Please note, access to the second story is via an outdoor spiral staircase.

A queen-sized murphy bed is neatly set against a vibrant blue wall, surrounded by wooden shelving units. The bed is adorned with light blue linens and a decorative pillow featuring a floral design. Natural light is allowed in through a nearby window, creating a bright and inviting sleeping space.

Guesthouse in Pacific Beach

4.96 out of 5 average rating, 193 reviews

Chez Christy

Cozy, quiet studio in the heart of Pacific Beach. Quick access to beaches, Pacific Beach Pier, Mission Beach, Mission Bay, shops, bars, and restaurants. Miles of walking and biking paths skirt the water; recreational opportunities abound. Fast & reliable WiFi and proximity to UCSD make this an ideal place for visiting professionals. We offer extended stay discounts as well, automatically applied.

Top guest favorite

A modern kitchenette features a contemporary design with checkered tile backsplash and wooden shelves. Mint green walls complement the white cabinetry and gray countertop. Three pendant lights hang above, illuminating the space adorned with various kitchen essentials and decorative items.

Guesthouse in Mission Beach

4.98 out of 5 average rating, 325 reviews

2 Free Bikes + Parking • Walk to Ocean

🔹Steps to the Boardwalk, Beach and Bayside 🔸ONE min walk - 2 cafes, 2 bars, a mini-market grocery store, and a liquor store 🔹Dedicated Parking pot 🔸Beach cruiser bikes included 🔹FIVE min walk to Belmont Park amusement park 🔸NINE min drive to SeaWorld 🔹Cuban Tropicana Style 🔸Umbrella, Beach Chairs & Towels 🔹Fully Stocked Kitchenette 🔸Mixology set 🔹Spa like shower

A bright studio space features a spacious bed with white linens and a decorative throw. A comfortable pullout sofa is situated across from a wall-mounted TV. Natural light enters through sheer curtains, while a patterned area rug adds color to the wood-like flooring.

Guesthouse in Pacific Beach

4.89 out of 5 average rating, 160 reviews

Sparkling Clean & Plush Studio in PB w /AC

Thank you for checking out our awesome Studio in the center of PB. Our recently remodeled studio is 7 blocks to the beach and within walking distance to restaurants, bars, shopping and, nightlife. The studio is bright and open with high ceilings and brand new everything! Enjoy 650 thread count luxury cotton linens, pottery barn duvet cover, feather duvet, air conditioning.

Vacation rentals for every style

Get the amount of space that is right for you

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Convenient locations with everyday essentials

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Quaint homes, peaceful surroundings

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A space thats all yours, with room for everyone

Popular amenities for Mission Bay, San Diego guesthouse rentals

Free parking on premises

Air conditioning

Family-friendly guest house rentals

A peaceful outdoor seating area is presented with a round table and several chairs. Silhouetted palm trees create a backdrop against the gradient sky, transitioning from dark blue to orange. A gentle light source adds warmth to the tranquil setting during twilight.

Guesthouse in La Jolla

4.79 out of 5 average rating, 196 reviews

San Diego Shangri La

Top guest favorite

A spacious studio room features a queen-sized bed with a blue comforter, enhanced by wooden beams overhead. A comfortable seating area includes a sofa and coffee table. Large glass doors open to a patio, allowing natural light to fill the space.

Guesthouse in La Mesa

4.99 out of 5 average rating, 280 reviews

Spacious, private Mt. Helix country style studio

Top guest favorite

A well-appointed sitting area features patterned seating and decorative tables set on a vibrant area rug. A door opens to an outdoor patio with a small dining table and chairs, allowing for seamless indoor-outdoor access. Walls are adorned with various framed artwork.

Guesthouse in Hillcrest

4.98 out of 5 average rating, 172 reviews

Hidden Casita with Private Deck & Patio

A bright and airy sleeping area is highlighted by a spacious bed with a striped duvet. Built-in shelving lines one wall, displaying books and decorative items. A ceiling fan and large window provide light and airflow, while a TV is mounted on the opposite wall.

Guesthouse in Greater North Park

4.96 out of 5 average rating, 706 reviews

BEAUTIFUL Private Studio

Top guest favorite

A spacious bedroom features a king bed with neutral bedding and decorative pillows. French doors provide natural light and open to a balcony overlooking lush greenery. A modern ceiling fan and soft lighting complement the hardwood floor and simple decor, creating a comfortable and inviting space.

Guesthouse in Greater North Park

4.97 out of 5 average rating, 189 reviews

New Guest House - North Park

Top guest favorite

A spacious living area is equipped with a plush sofa and light-colored chairs, accented by decorative pillows. A wooden coffee table rests on a colorful area rug. Natural light fills the room through two windows, highlighting a work desk and welcoming artwork on the wall.

Guesthouse in El Cajon

4.98 out of 5 average rating, 228 reviews

Fletcher Hills - modern 1 BR.Easy, no step access.

A well-equipped kitchen features wooden countertops and modern appliances. A dining area is set with a table covered in a light blue cloth, accompanied by two glasses. A piece of art hangs on the wall, adding color to the room, while outdoor seating is visible through the window.

Guesthouse in La Jolla

4.93 out of 5 average rating, 576 reviews

Modern Surf Cottage

A private terrace showcases ocean views complemented by a round table and four chairs. A large umbrella provides shade for outdoor seating, while a lounge chair invites relaxation. The surrounding landscape includes rooftops and palm trees, enhancing the serene environment.

Guesthouse in Ocean Beach

4.93 out of 5 average rating, 662 reviews

OB studio, ocean views, hot tub & garage parking!

Guest house rentals with a patio

Top guest favorite

A bright bedroom features a spacious bed with white linens, complemented by a cozy sitting area with decorative pillows. Large windows with shutters allow natural light to fill the room, and a small nightstand with a lamp adds functionality. A warm color palette enhances the welcoming atmosphere.

Guesthouse in Talmadge

4.99 out of 5 average rating, 213 reviews

Adorable cottage in Talmadge

Top guest favorite

A vibrant sunset casts warm hues over the landscape, with a glowing sun slowly descending behind the horizon. The scene is framed by lush trees, highlighting the natural beauty of the surrounding hills and distant views. The large expanse of sky transitions from orange to soft purple.

Guesthouse in La Mesa

4.99 out of 5 average rating, 100 reviews

Hilltop Haven~BALCONY~Sunset & Sunrise VIEWS!~

Top guest favorite

Two red Adirondack chairs are positioned under a covered patio, facing a serene backyard with a pool. Lush greenery surrounds the area, creating a tranquil atmosphere. A BBQ room and various seating arrangements are visible beyond the pool, enhancing the outdoor retreat experience.

Guesthouse in La Mesa

4.99 out of 5 average rating, 122 reviews

Private 1 BR Paradise retreat

Top guest favorite

A spacious sleeping area features a queen bed dressed in a soft plaid blanket, complemented by light blue pillows and a yellow throw. Framed floral prints adorn the walls above the bed. A kitchenette with modern appliances is visible in the background.

Guesthouse in Golden Hill

4.98 out of 5 average rating, 168 reviews

Cozy Urban Casita! Near Zoo, Gaslamp and Coronado

Top guest favorite

A private patio area is presented with a round dining table and four chairs, shaded by a large umbrella. Lush greenery surrounds the space, and sunlight filters through, creating a serene outdoor setting ideal for relaxation or dining.

Guesthouse in San Diego

4.96 out of 5 average rating, 113 reviews

SDSU Central Cozy Casita | Fast Wi-Fi | Walkable

Top guest favorite

A charming two-story casita is shown surrounded by lush greenery and palm trees. A large outdoor deck is visible, featuring an umbrella and comfortable seating. The terracotta roof complements the white exterior, while the inviting balcony windows provide a welcoming touch.

Guesthouse in San Diego

4.93 out of 5 average rating, 120 reviews

Charming Casita with City and Bay Views

A spacious studio features light-colored walls and wood flooring. A large bed is dressed in soft linens, accompanied by a side table with a lamp. A patio door opens to a private outdoor space, while a clothing rack and seating area are also visible.

Guesthouse in Serra Mesa

4.95 out of 5 average rating, 108 reviews

Cozy, Quiet and Private Backyard Studio Escape

The studio features a cozy sleeping area with a stylish four-poster bed dressed in crisp linens. A comfortable seating area is adjacent, complete with plush cushions and a small side table. Natural light filters through the window, highlighting the serene atmosphere.

Guesthouse in San Diego

4.88 out of 5 average rating, 223 reviews

Central studio w/ private outdoor space & parking

Guest house rentals with a washer and dryer

Top guest favorite

A coastal view captures a vibrant sunset over the tranquil ocean. The sunlight reflects off the water, and rocky formations frame the scene, enhancing the natural beauty. Grass and sparse foliage provide a contrast to the rugged landscape, inviting a sense of serenity.

Guesthouse in Sunset Cliffs

4.98 out of 5 average rating, 108 reviews

Casita at the Cliffs

An outdoor patio is surrounded by lush greenery, featuring vibrant flowers and ferns. A rustic wooden feature stands to one side, complementing the warm-toned brick flooring. A large glass door provides access to the interior, inviting natural light into the space.

Guesthouse in Hillcrest

4.88 out of 5 average rating, 208 reviews

Relaxing Oasis - short walk to shops & recreation

An outdoor living space is featured, showcasing a stone fireplace with a flickering fire. A cozy seating arrangement is present nearby, and a television is visible through a glass door, contributing to a relaxed atmosphere perfect for gathering.

Guesthouse in La Jolla

4.98 out of 5 average rating, 423 reviews

Beautiful Private Villa walk to beach

Top guest favorite

A private deck is shown, featuring a red umbrella over a round table with four chairs. The entrance to the guest house is framed by glass doors and accompanied by a vibrant red door. Lush greenery and flowerbeds enhance the outdoor space.

Guesthouse in La Mesa

4.99 out of 5 average rating, 192 reviews

Stunning Guest House 15 min. from Zoo, Downtown

Top guest favorite

A bright living area is characterized by large windows that invite natural light and provide views of greenery outside. A wall-mounted TV is positioned opposite a comfortable sofa, while a colorful dining chair adds a playful touch to the space.

Guesthouse in Del Cerro

4.99 out of 5 average rating, 152 reviews

The Happy Family * 2 playhouses near SDSU!

A private outdoor space features two wooden lounge chairs, adorned with striped cushions. The area is surrounded by a wooden fence, with a grill positioned nearby. Soft, artificial grass adds a green touch, and the sky above is bright and open, enhancing the outdoor ambiance.

Guesthouse in Pacific Beach

4.92 out of 5 average rating, 201 reviews

Brand New Cozy Detached Casita w/AC & heat

Top guest favorite

A cozy living area features a sectional sofa and wooden coffee table, complemented by a television mounted on the wall. Several light sources illuminate the space, including a ceiling fan. Decorative wall art adds a personal touch, while windows allow natural light to brighten the room.

Guesthouse in La Mesa

4.99 out of 5 average rating, 277 reviews

SDCannaBnB #1 *420 *parking *dog-friendly *hot tub

A spacious private deck features comfortable seating areas with black chairs and a table, shaded by striped umbrellas. Lush greenery and palm trees provide a natural backdrop, while the wooden deck offers an open area for relaxation and enjoyment of the scenic views.

Guesthouse in Bay Ho

4.94 out of 5 average rating, 127 reviews

Private San Diego Guest House - Beautiful View

Quick stats about guesthouse rentals in Mission Bay, San Diego

Total rentals
10 properties
Nightly prices starting at
R3,014 ZAR before taxes and fees
Total number of reviews
2.6K reviews
Wifi availability
10 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool
Local attractions
Mission Bay Park, Mission Beach, and Mission Beach Boardwalk | Ocean Front Walk

Destinations to explore