Guesthouse vacation rentals in San Diego County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in San Diego County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in San Diego

4.92 out of 5 average rating, 317 reviews

Mid Century Bungalow Near SDSU

This private bungalow sits behind a main house in the beautiful El Cerrito Neighborhood, (College Area). This is a studio type room with a bathroom, bed, and sitting area. There is a private side entrance and plentiful parking. Guests will have full access to the backyard which includes lounging area to enjoy the beautiful San Diego weather. Location is ideally located: 1 mile from SDSU 7 miles from Downtown San Diego 10-15 miles from local beaches 5 miles from North Park All locations are an affordable Uber.

Sep 7 – 14

R2,410 ZAR per night

Guest favorite

Guesthouse in San Diego

4.98 out of 5 average rating, 118 reviews

Casita Hermosa - Close to everything in San Diego

Stay in the quiet beauty of your own guest house and private garden patio. Recently remodeled, Casita Hermosa will delight your senses and relax your soul. Features include a private bedroom, living room, dining area, fully equipped kitchen, and a full bathroom. The entire unit will immerse you in the southern California lifestyle as you marvel at the decorative touches featuring surf, ocean, sun, beaches, and all the best that San Diego has to offer plus a nod to our southern neighbor, Mexico!

Oct 7 – 14

R3,361 ZAR per night

Guest favorite

Guesthouse in Valley Center

4.91 out of 5 average rating, 211 reviews

North San Diego Serenity

* Due to recent flu outbreaks we close the 2 days before and after booking for our safety and our quests. We are also a 2 guests max occupancy. I do require reviews to book. New Flooring!! Thank you Quiet Country GH w/beautiful Mt views . 45 Min to SD airport w/ Pala , Valley View & Casinos just 15 min. Local winery's and Brewery's 20 min. Parks & nature trails around the area, sunsets are free! Hills and scenic roads. SD Wild Park is 25 min . Comfortable! sleeps 2 Perfect . WIFI :-)

Nov 10 – 17

R1,841 ZAR per night

Guest favorite

Guesthouse in Encinitas

4.98 out of 5 average rating, 126 reviews

The Tiki Lounge, Leucadia, California

The Lounge is a quaint, cozy 400 sq. ft. one-bedroom detached guesthouse with lots of character in the "funky" community of Leucadia. Located just east of historic Highway 101 in a quiet neighborhood a mile from beach access, you're close to many eclectic shops, restaurants and entertainment. You'll also have access to a semi-private patio and shared access to our back yard, where, as of June 2023, Debe works 3 to 4 days a week in her studio. We really love it here and think you will too.

Sep 9 – 16

R2,545 ZAR per night

Guest favorite

Guesthouse in San Diego

4.93 out of 5 average rating, 357 reviews

Cozy Ocean Beach Casita

This cozy, clean casita is just 4 blocks to the beach, pier, great surfing, restaurants, bars, shopping, and Sunset Cliffs. You’ll love it for its walkability to everything you need. The casita is only 120 square feet, a very small space (small studio with everything in one room including the bathroom), for single occupancy only, but with everything you need to enjoy a San Diego getaway. It is great for solo travelers who want to be near the heart of Ocean Beach, San Diego, California.

Sep 30 – Oct 7

R1,998 ZAR per night

Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 284 reviews

Betty- Guesthouse near CBX & San Ysidro border

This comfy studio located in San Diego is the perfect spot for a quiet & cozy weekend retreat. Inside is bright & inviting with stylish spacious studio, private entrance from side gate, private patio with bbq & hanging hammocks; driveway parking spot & plenty of street parking! The view from the patio is very relaxing, making it the perfect weekend get away. Centrally located in a quiet & peaceful area within 5 minutes away from Plaza Las Americas & 10 minutes away from the CBX.

Feb 27 – Mar 6

R2,390 ZAR per night

Guest favorite

Guesthouse in Encinitas

4.86 out of 5 average rating, 228 reviews

Sunset/Ocean View Guest House! Minutes to Beach

Sunset/Ocean view guest house (one bedroom with a sofa bed)--386 Sunset Drive, 92024. Quiet residential neighborhood, close to downtown Encinitas, and half a mile from Moonlight Beach. Balcony features a propane barbecue, table, chairs, chaise lounge, and a distant view of the sunset and ocean. Living room/dining/kitchen area includes sofa bed. Living room features a 45" flat screen and DVD player. Bedroom includes a natural gas fireplace, television, and DVD player.

Nov 14 – 21

R2,721 ZAR per night

Guest favorite

Guesthouse in El Cajon

4.98 out of 5 average rating, 191 reviews

Fletcher Hills - modern 1 BR.Easy, no step access.

** 48 hours between check-ins. Thorough cleaning and sanitizing.. Four night minimum stay. Dogs ONLY are welcomed on a case by case basis. They must be house trained and are not permitted on any furniture. If you instant book, you must contact me about your pet within 24 hours. Smoking is permitted in the outside areas - patio, gazebo, yard. Easy freeway access helps any commute to downtown and area attractions. Having your own vehicle is the best way to get around..

Feb 26 – Mar 5

R2,219 ZAR per night

Guest favorite

Guesthouse in San Diego

4.99 out of 5 average rating, 364 reviews

*Private Canyon Retreat: Your Own Guesthouse*

An airy 1BD guest house at the end of a quiet dead-end street that overlooks a tranquil canyon....and an owner that works hard to create a fabulous experience for each guest; not just “another average rental”. With private entrance, full kitchen & bath, and double french doors opening onto a 400 sq ft deck with canyon views, it's the ideal retreat to come back to after exploring San Diego. Come fall in love with your next home away from home!

Dec 3 – 10

R3,015 ZAR per night

Guest favorite

Guesthouse in San Diego

4.95 out of 5 average rating, 109 reviews

Relax in a Centrally Located, Modern Guest House

Relax in a brand new studio that provides all the essentials with a touch of luxury. This spacious, detached guest house has a private entrance and is located in a fully-gated backyard. The casita is close to freeways and minutes to Coronado beach, Little Italy, the Gaslamp Quarter (downtown), Balboa Park, restaurants and shopping. The main house property owners, Stephen and Brittany, are usually home with their baby and German Shepherd.

Sep 8 – 15

R2,498 ZAR per night

Guest favorite

Guesthouse in Vista

5.0 out of 5 average rating, 200 reviews

New Tranquil Barn Retreat on a Peaceful Half Acre

The Buena Vista barn is a clean, quiet, and upgraded detached barn in Vista with everything you need for a peaceful and comfortable stay! Only 10 minutes to downtown Vista, you'll find great restaurants, breweries, shops, and a movie theater. Points of interest: • Downtown Vista: 10 minutes • Cal State San Marcos: 15-17 minutes • Beach: 20 minutes • Legoland: 22 minutes • Temecula and Wine Tasting: 30-40 minutes • Sea World: 47 minutes

Aug 30 – Sep 6

R2,769 ZAR per night

Guest favorite

Guesthouse in Dulzura

4.97 out of 5 average rating, 579 reviews

Vineyard & Winery Guest House

A hidden gem! Get away and stay at the historic pioneer era Clark Ranch established in 1885. Our guest house sits above our winery tasting room and has its own private entrance and driveway. It's clean, cozy, and self-contained . Make it a weekend 'getaway' stay and sample our fine wines , and Estate Olive Oil. There is a tower in the vineyard where you can enjoy a glass of wine and watch the sun set. Balcony overlooks Dulzura Creek.

May 30 – Jun 6

R2,636 ZAR per night