
Hotel vacation rentals in Mission Bay, San Diego
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Top-rated hotel rentals in Mission Bay, San Diego
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
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Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay, San Diego hotel rentals
Family-friendly hotel rentals

Resort in Coronado
5 out of 5 average rating, 10 reviewsCoronado Beach Resort

Hotel room in Tijuana
5 out of 5 average rating, 4 reviewsHobbit

Private room in Pacific Beach
4.63 out of 5 average rating, 54 reviewsPrivate Room in Hostel by the Beach, 2 Double Beds
Guest favorite

Hotel room in Oceanside
4.91 out of 5 average rating, 44 reviewsLuxury Beachfront Resort | Oceanside | 2BR | POOL
Superhost

Hotel room in Carlsbad
4.76 out of 5 average rating, 45 reviewsLuxury Villa #6550 at Omni's La Costa Resort & Spa
Hotel rentals with a patio

Hotel room in Poway
4.71 out of 5 average rating, 24 reviewsClean 2 Queen Bedroom in San Diego-Poway

Private room in Adams North
5 out of 5 average rating, 4 reviewsOhana House

Hotel room in Downtown San Diego
New place to stayQueen Studio in Central Little Italy (Patio/ADA)

Hotel room in Pacific Beach
4.17 out of 5 average rating, 6 reviewsPartial Ocean View Private Room

Shared room in Downtown San Diego
4.38 out of 5 average rating, 13 reviews1 Bed in a 6 Bed Dorm near San Diego Airport
Quick stats about hotel rentals in Mission Bay, San Diego
Total rentals
130 properties
Nightly prices starting at
R3,585 ZAR before taxes and fees
Total number of reviews
150 reviews
Family-friendly rentals
30 properties are a good fit for families
Pet-friendly rentals
70 properties allow pets
Rentals with a pool
130 properties have a pool
Destinations to explore
- Townhouse rentals Mission Bay
- Rentals with a beach view Mission Bay
- Rentals with pools Mission Bay
- Family-friendly rentals Mission Bay
- Rentals with a sauna Mission Bay
- Rentals with a kayak Mission Bay
- Beach house rentals Mission Bay
- Pet-friendly rentals Mission Bay
- Guesthouse rentals Mission Bay
- Rentals with a patio Mission Bay
- Apartment rentals Mission Bay
- Cottage rentals Mission Bay
- Rentals with an EV charger Mission Bay
- Waterfront rentals Mission Bay
- Rentals with breakfast Mission Bay
- Rentals with lake access Mission Bay
- Rentals with a fire pit Mission Bay
- Rentals with a hot tub Mission Bay
- Smoking-friendly rentals Mission Bay
- Rentals with a washer and dryer Mission Bay
- House rentals Mission Bay
- Kid-friendly rentals Mission Bay
- Rentals with outdoor seating Mission Bay
- Condo rentals Mission Bay
- Rentals with beach access Mission Bay
- Rentals with a fireplace Mission Bay
- Beachfront rentals Mission Bay
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- Rosarito Beach
- Oceanside City Beach
- Tijuana Beach
- Torrey Pines State Beach
- Pacific Beach
- Coronado Beach
- San Clemente State Beach
- Coronado Shores Beach
- Oceanside Harbor
- San Onofre Beach
- SeaWorld San Diego
- South Coronado Beach
- Black's Beach
- Windansea Beach
- Trestles Beach
- University of California San Diego
- Surf Beach
- LEGOLAND California
- San Diego Zoo Safari Park
- Balboa Park
- Playas Los Buenos
- Belmont Park
- Pechanga Resort Casino
- Liberty Station