
Guesthouse vacation rentals in Mission Bay, San Diego
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Mission Bay, San Diego
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay, San Diego guesthouse rentals
Family-friendly guest house rentals

San Diego Shangri-La

Hidden Casita with Private Deck & Patio

BEAUTIFUL Private Studio

New Guest House - North Park

Modern Surf Cottage

OB studio, ocean views, hot tub & garage parking!

*Private Canyon Retreat: Your Own Guesthouse*

2 BR/ 2 BA San Diego Getaway
Guest house rentals with a patio

Adorable cottage in Talmadge

Free Bikes. 5 min walk to Windensea Beach La Jolla

Private 1 BR Paradise retreat

Sunset Cliffs Studio

SDSU Central Cozy Casita | Fast Wi-Fi | Walkable

Charming Casita with City and Bay Views

Cozy, Quiet and Private Backyard Studio Escape

Central studio w/ private outdoor space & parking
Guest house rentals with a washer and dryer

Lovely Guesthouse in garden setting

Casita at the Cliffs

Beautiful Private Villa walk to beach

Stunning Guest House 15 min. from Zoo, Downtown

The Happy Family * 2 playhouses near SDSU!

Brand New Cozy Detached Casita w/AC & heat

Point Loma Private Apartment

Early 1900's Carriage House w/Views
Quick stats about guesthouse rentals in Mission Bay, San Diego
Total rentals
10 properties
Nightly prices starting at
R3,012 ZAR before taxes and fees
Total number of reviews
2.6K reviews
Wifi availability
10 properties include access to wifi
Popular amenities
Kitchen, Wifi, and Pool
Local attractions
Mission Bay Park, Mission Beach, and Mission Beach Boardwalk | Ocean Front Walk
Destinations to explore
- Pet-friendly rentals Mission Bay
- Rentals with a beach view Mission Bay
- Townhouse rentals Mission Bay
- Family-friendly rentals Mission Bay
- Rentals with a kayak Mission Bay
- Apartment rentals Mission Bay
- Condo rentals Mission Bay
- Rentals with a fire pit Mission Bay
- Beach house rentals Mission Bay
- Rentals with lake access Mission Bay
- House rentals Mission Bay
- Rentals with outdoor seating Mission Bay
- Rentals with a sauna Mission Bay
- Rentals with pools Mission Bay
- Cottage rentals Mission Bay
- Rentals with an EV charger Mission Bay
- Hotel rentals Mission Bay
- Waterfront rentals Mission Bay
- Rentals with a hot tub Mission Bay
- Kid-friendly rentals Mission Bay
- Rentals with a patio Mission Bay
- Rentals with a washer and dryer Mission Bay
- Rentals with breakfast Mission Bay
- Rentals with beach access Mission Bay
- Fitness-friendly rentals Mission Bay
- Beachfront rentals Mission Bay
- Smoking-friendly rentals Mission Bay
- Rentals with a fireplace Mission Bay
- Guesthouse rentals San Diego
- Guesthouse rentals San Diego County
- Guesthouse rentals California
- Guesthouse rentals United States
- Cabins United States
- Treehouses United States
- Tiny Houses United States
- Beach Houses United States
- Lakehouses United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Pacific Beach
- Tijuana Beach
- Coronado Beach
- San Clemente State Beach
- SeaWorld San Diego
- Oceanside Harbor
- LEGOLAND California
- San Onofre Beach
- University of California San Diego
- Coronado Shores Beach
- San Diego Zoo Safari Park
- Balboa Park
- Black's Beach
- Trestles Beach
- Surf Beach
- Belmont Park
- Pechanga Resort Casino
- Sesame Place San Diego
- Liberty Station
- Moonlight Beach
- Playas Los Buenos