
Hotel vacation rentals in Mission Bay
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Top-rated hotel rentals in Mission Bay
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay hotel rentals
Family-friendly hotel rentals

Stylish San Diego downtown Suite

Ocean Beach - Bed in a 8-Bed Mixed Dorm

Ocean Beach - Bed in 6-Bed Female Dorm

Ensuite Private Room at Stylish Hostel

Cozy Twin Room w/ Ensuite Bath, Desk & A/C in SD

Pet-friendly Hotel with Free Breakfast and Pool!

Clean 1 Bedroom San Diego-Poway

3BR Suite w/ Event Space & Resort Amenities Sleep8
Hotel rentals with a pool

1-Bedroom Hotel Suite - 2 beds

Recently reno’d escape near the Gaslamp Quarter

A glimpse of the bay & onsite eats at Dock 1953

Free Breakfast l La Quinta Mission Bay l King Room

Iconic Resort in San Diego

Beachside La Jolla Stay | 1 Unit | Near Shores

Playful escape near games & concerts at Petco Park

Downtown Delight: Pets Allowed, Parking, Pool!
Hotel rentals with a patio

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

Comic-Con 2026: Spacious King Suite + Sofa Bed

ITH Mission Beach Backpacker Hostel Mixed Dorm

2 bd/2 bth Resort Style Hotel

Worldmark Studio Sleeps 4
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