
Hotel vacation rentals in Mission Bay
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Top-rated hotel rentals in Mission Bay
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mission Bay hotel rentals
Family-friendly hotel rentals

Stylish San Diego downtown Suite

Ocean Beach - Bed in 6-Bed Female Dorm

Pet-friendly Hotel with Free Breakfast and Pool!

Stay Near Top Attractions | Balcony & Pet-Friendly

Ocean Beach - Bed in 6-Bed Mixed Room

Comic-Con 2025! Stay within walking distance!

Hotel Marisol Coronado - King Room

Luxury 1BR Suite Next to Famous Hotel Del Coronado
Hotel rentals with a pool

Recently reno’d escape near the Gaslamp Quarter

1-Bedroom Hotel Suite - 1 bed

Iconic Resort in San Diego

Soothing neutrals & killer coastline location

Beachfront Stay | 1 Unit | Near La Jolla Cove

Playful escape near games & concerts at Petco Park

Wyndham Bayside | Superior King | Skyline View

Free B’fast & Parking – Minutes to Pacific Beach
Hotel rentals with a patio

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

Comic-Con 2026: Spacious King Suite + Sofa Bed

2 bd/2 bth Resort Style Hotel

Worldmark Studio Sleeps 4

WorldMark San Diego Mission Valley Two Bedroom
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