
Vacation rentals in Panama
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Panama
Guests agree: these stays are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama vacation rentals
Panama house rentals

Luxury beachfront villa!

Casa Antares by Esther

Rustic family mountain home - 5 min walk to town!

Casa Colibrí - modern house in the green

Spacious accommodation with ocean views

Puntita Manzanillo, fantastic sea and jungle

Casa Clearwater... Your Caribbean Dream

The Dream of Playa Coronado
Other great vacation rentals in Panama

Casa del Mar - eco aqua villa

The Retreat in El Valle - Garden House

Luxury in the City and by the Sea

Luxury apt in Panama City 2 Rooms 3 Baths

Carenero Hills 3 - Beach & Surf Bungalows.

Amazing Overwater Villa in Basti

Saboga: El Remanso Beachfront Entire Upper Level

Private Pool Oasis in a Tropical Boutique Villa
Your guide to Panama
All About Panama
A narrow isthmus on the southern tip of Central America, Panama is the cultural gateway to South America and the geographical gateway between the Caribbean Sea and the Pacific Ocean. Panama City, its stunning capital city, juxtaposes old-quarter Casco Viejo against the shiny, soaring skyscrapers of the modern district — all surrounded by rolling green hills and vast blue ocean studded with tiny islands. The Metropolitan Natural Park, a wildlife refuge threaded through with hiking trails, is just 10 minutes away from downtown. And Taboga Island, a volcanic enclave featuring a rich array of plants as well as white-sand beaches, is easily reachable via a 30-minute ferry ride.
The terrain rises dramatically from white-sand Caribbean beaches to lush mountain jungles. Near the top of the country, altitude-wise, you’ll find Boquete, home to world-renowned coffee plantations, and the Quetzal Trail, one of Panama’s most scenic hiking trails. Leaving from Volcan Baru National Park, it passes through the Talamanca Mountain Range, where you’ll discover rare tropical wildlife including spider monkeys, tapir, and brightly colored frogs.
The best time to stay in a vacation rental in Panama
The lovely tropical climate makes the prospect of securing a vacation rental in Panama appealing all year long. The drier winter months are ideal for hitting the country’s hiking trails or visiting the beaches. Many of the country’s most significant religious festivals, including Carnaval and Semana Santa (Holy Week), occur in March and April. You’ll want to keep this in mind when booking your Panama house rental if you are headed to a city that hosts a big celebration.
Once Panama’s rainy season starts in May, the sunshine is interrupted with short bursts of heavy rain. It is also usually the quietest time of year for tourism, and you may find yourself alone in the country’s national parks or beaches. That all changes, of course, after the rainy season finishes in November and gorgeous, sunny weather returns.
Top things to do in Panama
Casco Viejo
As the oldest part of Panama City, settled in 1673, Casco Viejo is filled with beautifully restored French and Spanish-style buildings, with a touch of art deco flair. As you stroll down the cobblestone streets, past pastel-colored buildings housing trendy restaurants, upscale bars, and inviting coffee shops, time seems to shimmer between the 19th and 21st centuries. Explore the neighborhood during the day; return after dark for its lively nightlife.
Panama Canal
When the 51-mile Panama Canal opened in 1914, it provided a waterway through Central America and reduced the traveling distance between the Pacific and Atlantic Ocean by 8,000 miles. The impact that this had on global commerce is hard to underestimate. The Pacific mouth of the canal is 26 miles outside Panama City, making it easy to visit this engineering marvel and watch as enormous ships rise and descend through a series of locks.
Bocas Del Toro
Lying close to the border of Costa Rica, this collection of islands is Panama's most popular beach destination. Largely undeveloped, the islands are home to lush tropical rainforest. Great snorkeling and diving opportunities abound in the Isla Bastimentos National Park, which is home to a wide variety of Caribbean coral species as well as (gentle) nurse sharks, crab, and stingrays.
Destinations to explore
- Rentals with a fire pit Panama
- Fitness-friendly rentals Panama
- Bungalow rentals Panama
- Rentals with a fireplace Panama
- Cottage rentals Panama
- Mansion rentals Panama
- Private suite rentals Panama
- Family-friendly rentals Panama
- Lakehouse rentals Panama
- Beach house rentals Panama
- Chalet rentals Panama
- Island rentals Panama
- Treehouse rentals Panama
- Farmstay rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Apartment rentals Panama
- Rentals with a sauna Panama
- Boat rentals Panama
- Rentals with a home theater Panama
- Rentals with a hot tub Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- House rentals Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Rentals with an accessible height bed Panama
- Rentals with breakfast Panama
- Smoking-friendly rentals Panama
- Kid-friendly rentals Panama
- Rentals with pools Panama
- Villa rentals Panama
- Rentals with beach access Panama
- Guesthouse rentals Panama
- Rentals with a washer and dryer Panama
- Bed and breakfasts Panama
- Pet-friendly rentals Panama
- Loft rentals Panama
- Rentals with a patio Panama
- Hotel rentals Panama
- Nature eco lodge rentals Panama
- Waterfront rentals Panama
- Tiny house rentals Panama
- Townhouse rentals Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- Boutique hotel rentals Panama
- Condo rentals Panama
- Rentals with lake access Panama
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom