Hotel vacation rentals in Panama

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Panama

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Superhost

A furnished bedroom features a spacious bed with white linens, flanked by bedside tables with lamps. Soft artwork adorns the wall above, while a bench rests at the foot of the bed. A cozy throw drapes over the bench, completing the inviting arrangement.

Hotel room in Boquete

4.89 out of 5 average rating, 114 reviews

Villa Alejandro - Tastefully Furnished Room

Just 5 minutes walk to centre, calmly situated and close to town located in an extraordinary mansion. Lovely furnished bedroom (King-Size/Orthopedic mattress) with private bathroom and walk-in closet . Affectionately decorated living room with spectacular view to the Boquete valley by large windows and large, full equipped kitchen can be shared with other guests. Lot of space for dining/reading in the living room. Lovely garden and terrace can be used. Gated carport. Fast WiFi, CableTV, Netflix

Guest favorite

A spacious bedroom features a wooden platform bed with a blue patterned mattress. Large glass doors open to a private patio, surrounded by lush greenery. Two chairs are positioned on the terrace, and a colorful framed artwork adorns the wall near a window.

Hotel room in PA

4.9 out of 5 average rating, 29 reviews

Treetop views of the Pacific in a boutique cabaña

No detail left unnoticed…our boutique cabañas are nestled in jungle gardens with private porches overlooking the Pacific, hammocks for lounging, indoor/outdoor concept bathrooms, stunning hardwood floors, and custom-made furniture. Each of our three cabañas has its own unique charm where comfort meets luxury. We are steps from the beach and minutes from consistent surf breaks and community yoga classes. A shared kitchen is on site, with individual cooking utensils provided for each room.

Superhost

Hotel room in PA

4.91 out of 5 average rating, 35 reviews

Villa Coco King Room

Villa Coco is a beautiful boutique hotel in Santa Catalina, only footsteps away of the world known surf break “La Punta” and Unesco world heritage Coiba island. The carefully designed cabañas, provide a space of tranquility and a sense of timelessness. Unwind in the hammocks and canvas chairs on your private terrace, dwell on reading your favorite book or sip on a cool drink from the bar. Our Restaurant “Ai Mamita” offers different kinds of meat, fresh seafood and other tasty delights.

Top guest favorite

The bungalow features a screened-in porch, framed by lush greenery and colorful plants. Warm sunlight casts shadows across the wooden structure, creating a serene and inviting atmosphere amidst the surrounding foliage.

Hotel room in Bastimentos Island

4.95 out of 5 average rating, 64 reviews

Casa Florecer- bungalow at the edge of the sea

Welcome to Casa Florecer, a bungalow at the edge of the sea. Your space is simple and elegant. A studio apartment with plenty of room to enjoy a quiet & peaceful time on the island. The bungalow boasts a screened in porch, gorgeous views, and pristine coral reef for your front yard. All stays include a locally sourced vegetarian breakfast served in our over the water eatery, Juntos. For fun closer to home: we have snorkel gear, paddle boards, and yoga mats available for your enjoyment.

Superhost

A spacious room features a king bed with soft white linens and colorful striped accent pillows. The headboard is constructed from light wood, complementing the contemporary design. A view of the city skyline is visible in the artwork above the bed, enhancing the room's ambiance.

Hotel room in Panamá

4.82 out of 5 average rating, 11 reviews

Very Nice Downtown Panamá Hotel Free Parking

Welcome to the beautiful Aloft Panamá hotel This is a very nice and safe hotel located in the San Francisco area of Panamá with beautiful city views. King or 2 queen based on availability (Feel free to make request prior to booking if you have a preference) All rooms non smoking ($350 fine) No pets allowed Must be 21 with id to checkin Must have credit card for incidentals Checkin time starts at 3pm Checkout time before noon Free Parking Pool Bar/Lounge

Superhost

An outdoor terrace features several lounge chairs and tables shaded by large umbrellas. A swimming pool extends along one side, with a backdrop of modern high-rise buildings under a partly cloudy sky. Lush greenery is present in planters, adding a touch of nature.

Hotel room in Panamá

4.83 out of 5 average rating, 6 reviews

En el corazón de la ciudad.

Hotel Mio Panamá somos un hotel 4 estrellas situado en la ciudad de Panamá, en el corazón del área financiera. Nuestro principal objetivo es satisfacer cualquier necesidad del cliente, ofreciendo los mejores servicios para garantizar una estancia cómoda y tranquila. Entre nuestras modernas instalaciones, encontrará una piscina, habitaciones amplias y cómodas, gimnasio, salas de reuniones y rooftop. Si le gusta viajar con su mascota, somos pet friendly.

Superhost

A round wooden dining table is set for four, surrounded by light-colored chairs. A chandelier hangs above, casting a warm glow. Light enters through open doors, highlighting wall art and plants, creating a welcoming dining space.

Casa particular in Dolega District

5 out of 5 average rating, 4 reviews

Wanakaset Forest Haven 2BR, River & shared Pool

Casa Quetzal is a serene 2-bedroom retreat nestled in the lush forest of Wanakaset Panama, perfect for up to 4 guests. With its open-plan living space, modern bathrooms, and fully equipped kitchen, it offers comfort in a natural setting. Relax on the private terrace or enjoy the shared pool, just a short walk away. Surrounded by rivers and tropical greenery, it’s an ideal escape for nature lovers seeking tranquility and a peaceful getaway.

Guest favorite

A circular pool is surrounded by lush greenery, including vibrant flowers and palm leaves. A person in swimwear stands in the shallow water, with arms raised, creating a lively focal point. The pool is equipped with a ladder for easy access.

Private room in Panamá Oeste

5 out of 5 average rating, 5 reviews

Iwanna Green Ecolodge Habitación con Baño privado

Descubre tu oasis eco-amigable en el corazón de un hermoso entorno natural. Nuestra habitación con baño privado ofrece: Cama Full más sofá-cama Full Baño amplio, privado, con amenidades eco-amigables Ventanas con vista al jardín, ideal para relajarte Wi‑Fi gratuito de alta velocidad Desayuno saludable incluido (tostadas, huevos, frutas de temporada / café y más ) Espacios comunes: terrazas, piscina, espacios para descanso y más

Guest favorite

A cozy sleeping area features a plush bed with a light-colored quilt and dotted pillows. A bedside table holds a small lamp, providing soft lighting. The wall is adorned with a unique decorative panel, and a ceiling fan offers comfort.

Private room in Panamá

4.82 out of 5 average rating, 22 reviews

Desk & Dream Room

Disfruta de la comodidad de este alojamiento tranquilo y céntrico en el corazón de San Francisco, tiene escritorio dentro de la habitación para trabajar o estudiar en un ambiente relax, con las demás comodidades incluyendo televisor led HD de 32" Justo en la calle de al lado está el super mercado, farmacia al frente, restaurantes, tiendas de chinitos, panaderías, paradas del metro bus cercanas.

Guest favorite

A serene outdoor seating area is featured on a wooden dock above the water, illuminated by soft string lights. Guests are seen relaxing under thatched umbrellas, with a picturesque sunset reflecting on the calm surface of the sea.

Hotel room in Bocas del Toro

4.99 out of 5 average rating, 71 reviews

BarrBra / Double Bed / Priv. Bath. / Ac

- house built right over the Caribbean sea - bedroom with double sized bed & balcony - private bathroom (hot water shower) - air conditioning included - a la carte breakfast included (between 8 - 9:30 a.m.) - guest kitchen - sunset orientated (yes, we're facing west! :)) - ocean access from our private dock - in-house kayak, bike and snorkel gear rentals - gay-friendly place

A wooden cabana sits elevated on stilts, topped with a thatched roof. Steps lead up to the open side, revealing a cozy interior. Surrounding foliage includes a variety of trees and plants, contributing to the natural setting of the community.

Nature lodge in Darién Province

4.7 out of 5 average rating, 20 reviews

La Chunga

La Chunga is in a difficult access indigenous community without electricity or roads. Come see this gem of a community and the indigenous way of life. You’ll love this place because of the nature walks, the wildlife, the gastronomy, and the people. We have a number of guided tours and adventures. My place is good for adventurers trying to see something new and exciting.

Guest favorite

Large green doors open to a charming balcony, revealing a view of a red-tiled roof and a small table with two chairs. A soft sofa is positioned nearby, complementing the inviting atmosphere of the space.

Hotel room in Panamá

4.86 out of 5 average rating, 105 reviews

Corcho rooms #2 - king room with balconies

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.