Boutique hotel vacation rentals in Panama

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Panama

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Superhost

A modern bathroom sink is situated on a wooden countertop, accompanied by a small potted plant. A sleek black faucet complements the square white basin. A dark blue towel is neatly placed next to the sink, while a bottle of liquid soap can be seen in the background.

Hotel room in Panamá

4.86 out of 5 average rating, 7 reviews

Avani Eco Hotel ~ Romantic Nature Getaway ~ Patio!

Step into the comfort of this beautiful queen suite in the high-end, eco-friendly Avani Boutique Hotel, offering easy access to sandy beaches and the many stunning amenities and activities of Contadora Island. Spend the day exploring this breathtaking island and then retreat to the attractive suite whose stylish design and scenic surroundings will mesmerize you. ✔ Comfy Queen Bed ✔ Spa-Like Bathroom ✔ Private Patio ✔ Wi-Fi ✔ Hotel Amenities (Breakfast, Transport, Activities) Learn more below!

Superhost

Large windows provide a panoramic view of the lush green landscape outside, featuring a mix of trees and colorful foliage. A comfortable sofa is positioned nearby, accompanied by a coffee table adorned with a floral arrangement, adding a touch of nature to the inviting indoor space.

Hotel room in Boquete

4.89 out of 5 average rating, 110 reviews

Villa Alejandro - Tastefully Furnished Room

Just 5 minutes walk to centre, calmly situated and close to town located in an extraordinary mansion. Lovely furnished bedroom (King-Size/Orthopedic mattress) with private bathroom and walk-in closet . Affectionately decorated living room with spectacular view to the Boquete valley by large windows and large, full equipped kitchen can be shared with other guests. Lot of space for dining/reading in the living room. Lovely garden and terrace can be used. Gated carport. Fast WiFi, CableTV, Netflix

Guest favorite

A spacious bedroom is illuminated by natural light from large glass doors that open to a private patio with a treetop view of the Pacific Ocean. A table and mini-fridge are positioned in the room, complemented by elegant hardwood floors.

Hotel room in PA

4.9 out of 5 average rating, 29 reviews

Treetop views of the Pacific in a boutique cabaña

No detail left unnoticed…our boutique cabañas are nestled in jungle gardens with private porches overlooking the Pacific, hammocks for lounging, indoor/outdoor concept bathrooms, stunning hardwood floors, and custom-made furniture. Each of our three cabañas has its own unique charm where comfort meets luxury. We are steps from the beach and minutes from consistent surf breaks and community yoga classes. A shared kitchen is on site, with individual cooking utensils provided for each room.

Guest favorite

An aerial view showcases a lush landscape featuring several charming cabins with red-tiled roofs nestled among greenery. A swimming pool is visible to one side, surrounded by well-maintained gardens and tall palm trees, creating a serene and natural environment.

Hotel room in PA

4.91 out of 5 average rating, 34 reviews

Villa Coco King Room

Villa Coco is a beautiful boutique hotel in Santa Catalina, only footsteps away of the world known surf break “La Punta” and Unesco world heritage Coiba island. The carefully designed cabañas, provide a space of tranquility and a sense of timelessness. Unwind in the hammocks and canvas chairs on your private terrace, dwell on reading your favorite book or sip on a cool drink from the bar. Our Restaurant “Ai Mamita” offers different kinds of meat, fresh seafood and other tasty delights.

Superhost

A shaded outdoor seating area is highlighted by a vibrant red hammock, providing a relaxed atmosphere. Lush greenery, including palm trees, is visible in the background, along with a well-maintained lawn leading toward a serene view of the ocean.

Hotel room in Playa Venao

4.75 out of 5 average rating, 4 reviews

Ocean View Private King Bed Room @ Villa Marina

Amamos el océano tanto como tú. Por eso hemos creado el lugar perfecto para que disfrutes de las olas y de todo lo que el Pacífico panameño tiene para ti en las playas de Pedasí. Villa Marina Lodge es un lugar único en su categoría. Ubicado en Playa Venao, un paraíso internacional del surf, ofrece habitaciones cómodas y amenidades de primera para que tu viaje a la playa sea siempre una experiencia especial. Un lodge, a diferencia de un resort, es más relajado, casual y acogedor.

Two individuals are engaged in a game of Jenga at a round wooden table, complemented by bottles of craft beer and glasses of light-colored beverages. A small bowl of snacks is visible, set against a textured bamboo backdrop that adds warmth to the atmosphere.

Hotel room in San Carlos

4.77 out of 5 average rating, 126 reviews

B) Beach, surf and Relax with King size bed

Manglar Lodge is a small beach Hotel located at El Palmar beach on the Pacific coast on the town of San Carlos, If you like nature and comfort, you'll enjoy your stay at Manglar Lodge We are small beach hotel that offers the visitor four cozy and clean rooms, WiFi, restaurant (open form 8.30am until 9pm) with great food and a great selection of craft beer and live music on some weekends from 7pm to 9.30pm The Room is on a 1 floor you have to walk up the stairs

Guest favorite

Shaded lounge areas are positioned under traditional thatched roofs, offering relaxation amidst the greenery. The setting is surrounded by palm trees and well-maintained grass, with stone pathways leading to the entrance of a charming building that features a terracotta roof.

Hotel room in Playa Venao

5 out of 5 average rating, 10 reviews

Palmas Room - Tranquil Space with King Bed

This 2 person room is wonderful for calm and relaxation. With beautiful rustic decor, a comfortable king bed, A/C, hot/cold water, mini fridge, smart tv (ready for your streaming login), this room will allow you to wash away the salt and sand and relax after fun days surfing and laying on the beach. *Additional guest, available to kids up to 12 years old.* *A 10% tax will be collected separately as Airbnb do not collect tax in behalf of the host.*

Guest favorite

Hotel room in Bastimentos Island

5 out of 5 average rating, 28 reviews

Amanecer : Delicious Included Breakfast

Amanecer is our sunrise apartment. The space is immersed in the jungle with an ocean view. This two room, 3 person apartment has memory foam bedding, strong wifi, and stunning views. This apartment is a great choice for a family or group of friends. Two bedrooms with a bathroom in the middle. Enjoy new yoga shala, snorkeling our private reef, & FREE local organic breakfast served in our over the water eatery, Juntos.

Guest favorite

A spacious bed is presented with crisp white linens and several pillows. On either side, two softly glowing lamps provide warm lighting. Above the bed, an abstract painting adds a pop of color against the muted green wall, contributing to the room's calming ambiance.

Hotel room in Panamá

4.88 out of 5 average rating, 41 reviews

Habitaciones privadas Sofia's B&B Hostal Boutique

Alojamiento tipo hostal boutique, contamos con 7 cómodas habitaciones privadas con baño, para una capacidad total de 18 huéspedes. La tarifa mostrada por Airbnb para tu reserva distribuye 2 huéspedes por habitación, es decir, los huéspedes deberan compartir camas y/o habitaciones. Si requieres una distribución especial de habitaciones para tu grupo, contacta primero con el anfitrión, ya que la tarifa podría variar.

Superhost

An outdoor seating area features wooden barstools and dining tables, situated beneath a covered patio. Natural light filters through, casting soft shadows on the polished floor. Lush greenery is visible in the background, enhancing the tranquil ambiance of the space.

Hotel room in Cambutal

4.94 out of 5 average rating, 17 reviews

Boutique Inn_The Hill 2_Private Entry_Tripple_+16

The Hill Panama, our Boutique Inn Adult Only (16+) is proud to be featured on Architectural Digest Magazine, located in the heart of enchanted Cambutal Beach, just a 5 five-minute walk to the beach, surrounded by several surf spots, balance between mountain and sea, hidden amongst the jungle canopy. This listed Room 2 was designed as a boutique hotel room with separated private entry and communal kitchen.

Guest favorite

A stone structure is illuminated against a dark sky, surrounded by lush greenery and mountains. The design features arched doorways and a warm atmosphere. Outdoor lighting highlights the pathway and patio areas, creating a welcoming ambiance for evening gatherings.

Hotel room in El Valle de Antón

4.75 out of 5 average rating, 24 reviews

Suite medievale natura & arte

La Corte del Re é un hotel boutique composto da un insieme di suite con tematica medievale (arte macabra) immerse nel bosco dove arte e natura si fondono nel cuore del Valle di Anton. A pochi passi dal centro sono dotate di tutti i confort e contano con un parco, piscina, lago con carpe Koi e parcheggio. Sono suite e pertanto non dispongono di una cucina.

Guest favorite

A spacious patio area features multiple black wicker chairs arranged along a colorful stone pathway. The outdoor space offers unobstructed views of the sandy beach and ocean beyond, with a wooden railing providing a sense of enclosure. People can be seen enjoying the beach in the distance.

Hotel room in Las Tablas Abajo

4.82 out of 5 average rating, 79 reviews

Blue Room for 2 at Casa Lassini - Oceanfront!

Blue Room - possibly our best room but you can decide. Queen bed, sleeps 2 and comes with everything you need to enjoy yourselves at the beach. A spectacular view overlooking the Pacific Ocean. Room is upstairs; includes A/C, smart TV, Netflix, full size refrigerator, microwave, toaster, coffee & coffeemaker.