Vacation rentals in Medicine Lake

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Top-rated vacation rentals in Medicine Lake

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Guest favorite

A spacious A-frame studio features wooden walls and vaulted ceilings. Two skylights provide natural light, illuminating a seating area with a couch and decorative items. A large bed occupies one corner, with a cozy rug beneath a wooden coffee table situated at the center.

Loft in Ventura Village

4.91 out of 5 average rating, 1,103 reviews

Tree-Top Urban Cabin with Private Porch & Loft

Looking for a get-away? In town for a concert? This cedar-plank, A-frame studio with its own private porch offers a woodys feel downtown. Just blocks from the Blue Line Metro, it has all of the downtown/airport accessibility and easy transfers to the Green Line Metro to St. Paul and the University of Minnesota. This studio has its own loft, two queen beds and kitchen with stove/oven, fridge, sink, microwave, high-speed wireless internet, ample work space, and its own tree-level private porch.

Top guest favorite

A cozy living area is highlighted by a modern sectional sofa adorned with textured cushions. A chic wooden coffee table with a decorative bowl sits in front. Large windows allow natural light to fill the space, complementing the warm green walls.

Apartment in Bryn - Mawr

5 out of 5 average rating, 281 reviews

Urban Oasis Close to Downtown w/ Private Sauna

Welcome to Maison Belge, a luxurious garden-level apartment with a private entrance and modern European charm. Nestled in a beautiful Minneapolis neighborhood and surrounded by the largest park in the city, you’re only minutes away from downtown. Enjoy a fully equipped kitchen, laundry room, and authentic sauna. Designed for comfort and relaxation, our 5-star retreat is your home away from home. Can't find your desired dates? Need a longer stay? Contact us for availability and arrangements.

Guest favorite

A private hot tub is positioned on a deck, surrounded by wooden fencing that offers privacy. The water appears inviting, while sunlight filters through the lush trees in the background, creating a serene outdoor setting.

Home in Minneapolis

4.97 out of 5 average rating, 174 reviews

Hidden Garden Suite & Spa: Sauna & Hot Tub

Perfect for anniversaries, birthdays, or simply a rejuvenating getaway. Find out why Minnesotans enjoy the winter as you relax in the 104* hot tub or 190* sauna while gazing into the trees. Included is a king bed, sofa bed, lush robes, slippers and numerous amenities for you to enjoy! This unit is attached to a larger home (that is available for rent). However, only one group stays on the property at a time, by either renting this smaller space or by renting the entire house.

Guest favorite

An inviting living space features a brown sofa, a white coffee table, and a patterned area rug. Nearby, a dining table is visible, complemented by large windows that allow natural light to brighten the room. The open layout connects to the kitchen area.

Home in Minneapolis

4.98 out of 5 average rating, 129 reviews

Light & Bright MN Retreat 15 mins from everything

This charming home features 4 bedrooms and 4 beds, and 2 baths. The open floor plan seamlessly connects the living room to the dining area and kitchen, with beautiful flooring, stainless steel appliances, and an impressive stone fireplace. This home provides a warm and welcoming atmosphere with all new furniture. A fenced-in yard with a huge deck perfect for entertaining. The combination of modern amenities and timeless features creates an atmosphere that feels just right!

Top guest favorite

The luxury master bathroom features marble tiled walls, a whirlpool jet tub elevated on a platform, and a glass-enclosed steam shower. Double sinks with sleek design are complemented by modern fixtures. Natural light flows in through multiple windows, enhancing the spacious atmosphere.

Guest suite in Nokomis

4.99 out of 5 average rating, 449 reviews

SpaLike Private Oasis

Spa quality stay in a private-entry, large master suite, minutes from airport and MOA. High end amenities you won't find in most hotels, all to yourself! Relax in a luxury 2 person hot tub & steam shower. Cuddle up in a comfy lounge area! Convenient kitchenette & work space. In the heart of peaceful SE Mnpls, we are blocks away from Lake Nokomis beaches, trails, rentals, unique dining & more. 15 minutes to downtown. Come pamper yourself while you discover Minneapolis!

Guest favorite

Home in Plymouth

4.92 out of 5 average rating, 378 reviews

Blue Cabin

LOCATION: Entire house located off Hwy 169 on the frontage road. Please note the house is right off the highway. My unit is a 650 sq ft house. One bedroom 1 bathroom. Has a full kitchen and laundry free to use. • PROFESSIONALLY CLEANED • EASY ACCESS TO DOWNTOWN (15 MINS) • EASY ACCESS TO AIRPORT & MALL OF AMERICA (30 MINS) • MEDICINE LAKE WALKING PATHS (2 MIN) • FREE COFFEE • FREE PARKING • FREE FAST WIFI • SELF CHECKIN WITH KEYPAD NO SMOKING AND NO PETS PLEASE

Top guest favorite

The spacious living area features polished hardwood floors and a cozy sofa paired with a tufted ottoman. A dining table with chairs is positioned near a kitchenette, which showcases elegant cabinetry and modern appliances. Natural light filters through a window illuminating the room.

Guesthouse in Minnetonka

5 out of 5 average rating, 324 reviews

Minnetonka Carriage House Guest Suite

This is a separate guest suite built with excellence, comfort, and relaxation in mind. It has a separate entry inside the Carriage House. Owner works in and around the hospitality industry and has a goal to make your experience here a great one: great bed and sleep, great shower, great place to work and to relax. In a residential area but close to many great restaurants, retail shops, and services . This is designed for business travelers or couples.

Guest favorite

A spacious bedroom features a king-sized bed adorned with a subtle patterned blanket. Natural light flows through sliding glass doors that lead to a garden area. A comfortable chair sits in the corner, and a desk with a lamp adds functionality to the room.

Condo in Minneapolis

4.84 out of 5 average rating, 321 reviews

Entire apartment ready for your stay. Very Private

For your enjoyment is a clean one bedroom apartment in my home. It has its own private entrance, reserved parking, a luxurious bathroom with a deep soaker tub and a fully equipped kitchen. In the bedroom is a king sized bed and a smart TV connected to the internet for your use. The home is located on a cul de sac in a quiet neighborhood that is close to everything. Within blocks of the house, there are restaurants, shops and several grocery stores.

Top guest favorite

A spacious living area features restored wood floors and large windows allowing natural light to fill the room. A comfortable sofa is paired with a coffee table on a striped rug. A desk with a task chair is visible, along with a wall-mounted television.

Guest suite in Lowry Hill

4.98 out of 5 average rating, 487 reviews

Solar-Modern-Historic Suite, by Walker Art Center.

Charmingly historic, quiet, residential neighborhood. The private, fully solar powered guest suite brings a modern aesthetic into a historic setting. Light-filled, spacious attic suite offers the feel of home. Enjoy the sun rise from the bedroom window, relax in the living room or stroll the quite streets around the lakes. We take the health and safety of our guests very seriously. We do our best for the utmost thorough cleaning.

Top guest favorite

A cozy living area is featured, with large windows allowing natural light to fill the space. A comfortable black leather sofa faces a television, while a wooden desk and chair provide a workspace. Soft lighting is created by two standing lamps and a small table lamp.

Apartment in Minneapolis

5 out of 5 average rating, 18 reviews

The Basswood

A peaceful, bright one-bedroom, above-the-garage suite in New Hope, MN. Perfect for solo travelers or couples, this cozy space offers the convenience of a kitchenette, relaxing living area, bedroom with a queen-size bed, designated office desk. Step outside onto the spacious upper deck. Convenient West Metro location near downtown Minneapolis (Target Center, Twins Stadium, US Bank Stadium). Easy access to the highway system.

Top guest favorite

A serene dock extends into tranquil waters, featuring two wooden Adirondack chairs positioned to enjoy the sunset. The sky is painted in soft hues of orange and pink, reflecting beautifully on the calm lake surface surrounded by green foliage.

Cottage in Minneapolis

4.99 out of 5 average rating, 71 reviews

Koselig Cottage on Medicine Lake

Thoughtfully renovated 3B/2BA lake home with cozy treehouse vibes, Koselig Cottage on Medicine Lake is the perfect spot to relax after a day of exploring the Twin Cities! With it's stunning lake views and convenient, family-friendly location, it adorns the best of both worlds. "koselig" - [koosh-lee] adjective, Norway "A feeling of deep contentment, provided by a person, place, or atmosphere"

Top guest favorite

The living area showcases a large, comfortable sofa paired with a round coffee table. A wide-screen TV is mounted on the wall, displaying a scenic city view. Warm wood accents and a colorful area rug enhance the inviting atmosphere of the open space.

Guest suite in Minneapolis

4.99 out of 5 average rating, 136 reviews

Private Luxury Suite | Near North Loop & Nature

Newly built, 700 sq ft spa-like retreat near Theodore Wirth Park. Walk to ski trails, biking paths, or golf, and enjoy a 6-min drive to North Loop and Downtown Minneapolis. This private unit features its own entrance, fiber-optic internet, a fully stocked kitchen, and a serene atmosphere—perfect for couples, small families, and professionals seeking relaxation.