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Guesthouse vacation rentals in Knox County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Knox County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A cozy sleeping area features a spacious bed adorned with a lace coverlet. A comfortable sofa and armchair offer seating under the warm glow of two lamps, while a decorative rug adds texture to the wooden floor. Artwork decorates the walls, enhancing the room's charm.

Guesthouse in Oak Ridge

4.98 out of 5 average rating, 395 reviews

The "Tree House" - Privacy, Luxury, Nature Views

The elegant "Tree House'' is not in a tree but feels like it, with large windows overlooking lush forest or mountain views. This 450 sf space is a separate unit with own entrance & porch--no stairs! Queen bed, sofa, stone/tile bathroom & walk-in shower, washer-dryer, big TV, fast WiFi, birdfeeders at window. Located on cozy cul-de-sac, reserved parking. This architect-designed space has a kitchenette with fridge, toaster oven, microwave, Keurig coffee, more. Hiking trails near by! Non-smoking.

Guesthouse in Maryville

4.92 out of 5 average rating, 169 reviews

Relax in a Smoky Mtn getaway near Knoxville

Welcome to our centrally located residence! Explore Pigeon Forge & Gatlinburg (1hr away), perfect for motorcycle enthusiasts with easy access to Tail of the Dragon and Foothills Parkway. Nearby bike/walking paths, 30min to downtown Knoxville, and 4 miles from the airport. Restaurants, fast food, and shopping within 15 minutes. Please note that ALL outdoor spaces are SHARED with your host. We respect your privacy and won't intrude on your grilling or swimming experience. Smoking is not allowed.

Top guest favorite

A bright living area features a comfortable beige sofa and a wooden media console with a flat-screen TV. An orange pouf is placed nearby, and natural light floods through the multiple windows, highlighting the textured rug on the light wooden floor.

Guesthouse in Knoxville

5 out of 5 average rating, 55 reviews

La Casetta, SoKno

Welcome to this brand new lovely apartment nestled among the trees in the vibrant South Knox area of Knoxville! I love hosting people, at my house, at my Airbnb in Milan and finally in ourAirbnb in Knoxville.The apartment is light and airy, with plenty of windows and surrounded by a large maple and walnut, which gives it a tree-house feel.The open kitchen is fully equipped, the bathroom features a large shower with a skylight as well as the bedroom.A cozy outdoor space for guests is available.

Top guest favorite

Guesthouse in Knoxville

5 out of 5 average rating, 33 reviews

Knoxville Modern Comfort: Hot Tub-Patio-Grill-Pets

Welcome to your private Knoxville retreat! This modern 1-bedroom, 1-bath guesthouse offers a great mix of comfort and relaxation. Unwind on the private patio, soak in the hot tub under the stars, or relax inside with chic decor and cozy vibes. Located in a quiet neighborhood in North Knoxville/Fountain City — just minutes from downtown, UT, and the Smoky Mountains. We love travelers from all walks of life - and their pet friends too! Perfect for: Couples, solo travelers, and business stays

Top guest favorite

A charming modern log house is nestled among trees, featuring a metal roof and a welcoming porch. Surrounding greenery and landscaped flower beds enhance the natural setting, providing a serene entrance to the home.

Guesthouse in Maryville

4.98 out of 5 average rating, 217 reviews

Little River Cabin in the Woods

Upon your arrival to this secluded setting, you will find a charming modern log house. No detail has been overlooked in the decor and furnishings to make you feel at home. On the main floor is a generous living area which includes a contemporary kitchen with many amenities, a bathroom with a walk-in shower and a laundry room, if needed. Up the staircase is the loft with a king size bed, a twin XL daybed and a sleeper sofa. Please note: this property is unsuitable for infants or children.

Top guest favorite

A welcoming living area features a sleek futon and a woven chair, arranged on a patterned area rug. Natural light fills the space through sliding glass doors, which lead to an outdoor deck, framed by lush greenery visible outside.

Guesthouse in Powell

4.99 out of 5 average rating, 228 reviews

Private Guesthouse—serene & conveniently located!

Surrounded by woods, this peaceful studio guesthouse provides a retreat-like setting close to our vibrant downtown. The private quarters feature granite countertops, fully-stocked kitchen, separate entrance, comfy bed, sun-filled rooms & a lovely, outdoor seating area to enjoy the quiet. *4 min to Kroger grocery & restaurants *6 min to Tennova North Hospital—perfect for travel nurses! *12 min to downtown *16 min to UT's Neyland Stadium & Thompson Boling Arena *1 hr to the Smoky Mountains

Top guest favorite

The exterior of the cottage is displayed, featuring a white facade with large windows and a central door. A slate patio leads to the entrance, framed by decorative plants. A bench is positioned nearby, and a parked trailer is visible on the left.

Guesthouse in Knoxville

4.98 out of 5 average rating, 49 reviews

The Burrow • A Fountain City Cottage

Burrowed in the trees just enough to feel secluded, but close to everything Knoxville has to offer, this little gem will feel like home the second you step inside. While you share a driveway with the host, the house is completely separate. Less than 15 minutes from UT campus, Thompson Boling Arena, and Neyland Stadium. Less than 30 miles to Pigeon Forge and just a little farther to Gatlinburg and the Smokies. 5 minutes to groceries, restaurants and coffee 10 minutes or less to shopping

The charming cottage is framed by a wooden structure with hanging plants and a grill positioned in the center of a landscaped backyard. Sunlight filters through the trees, casting patterns on the deck, while the cozy exterior hints at a welcoming atmosphere.

Guesthouse in Knoxville

5 out of 5 average rating, 20 reviews

Guest House/Studio 2 miles to downtown

This 850 sf 2-story small cottage, suitable for a couple or one person, is next to the main house, yet very private. The top floor has a queen bed, large desk, a compact bathroom with a jetted bathtub, a closet, & a sun deck. The ground floor offers a kitchenette & a dining & seating area w/a queen sofa bed. *Fast wifi *Washer & dryer *Ample free parking *Backyard w/outdoor deck *2 miles to downtown and 3 miles to UT *Easy access to I-40 & I-275 Please read the House Rules carefully.

The exterior of a two-story structure is presented, surrounded by dense greenery. A covered porch is visible, along with a sizable parking area that accommodates multiple vehicles. The natural setting offers a sense of privacy and seclusion, enhancing the connection to nature.

Guesthouse in Knoxville

4.84 out of 5 average rating, 74 reviews

Ball Camp Hill

Your family will be centrally located when you stay at Ball Camp Hill. Enjoy your stay with country living and city life. You will stay in a secluded area surrounded by nature; at times you can see the wild turkeys and deer strolling through. You will only be a few minutes away from Turkey Creek shopping center. We have several Medical Centers within a few minutes. Pigeon Forge and Gatlinburg are only 50 minutes away. We are only 15 minutes from downtown, market square and UT stadium.

A view of the Smoky Mountains is visible in the distance, framed by lush greenery. The sky transitions into soft hues of pink and orange, suggesting a serene sunset atmosphere.

Guesthouse in Knoxville

4.96 out of 5 average rating, 314 reviews

*MINUTES to DOWN TOWN *MOUNTAIN VIEWS*PETS OK*

Our Walnut Grove Guest House is on 6.5 acres w/ 360 degrees of privacy & breath-taking views of the Smoky Mountains. Located in Fountain City, we are minutes to downtown Knoxville, & surrounded by shops & restaurants. We are close to many activities & a short drive to the Mountains, Dollywood, Pigeon Forge & Gatlinburg. You’ll love our place because of the coziness, the views, & the location. Our place is good for couples, solo adventurers, business travelers, & families (with kids).

Top guest favorite

A cozy sleeping area features a spacious bed with white linens and several pillows, arranged against warm wooden paneling. Soft wall sconces provide gentle illumination. A decorative mirror is positioned above the bed, reflecting light from a nearby window.

Guesthouse in Knoxville

4.95 out of 5 average rating, 220 reviews

Private North Knox Guesthouse - close to downtown

In the middle of beautiful trees, this peaceful studio guesthouse provides a refreshing setting very close to downtown. The private quarters feature fresh white linens, fully-stocked kitchen, separate entrance, comfy bed, sun-filled rooms & a lovely, outdoor seating area. *4 min to Kroger grocery & restaurants *11 min to Tennova North Hospital, perfect for travel nurses! *12 min to downtown *13 min to UT's Neyland Stadium & Thompson Boling Arena *50 min to the Smoky Mountains

An open concept living space features a cozy gray couch, a wooden coffee table, and a dining area with bar stools. A well-equipped kitchen is visible, including stainless steel appliances. Above, a ladder leads to a lofted sleeping area, while framed artwork adorns the walls.

Guesthouse in Knoxville

4.92 out of 5 average rating, 734 reviews

New Studio! Foam Bed, Hot Tub, Close to Downtown!

Studio apartment with lofted queen fully-foam mattress, full kitchen with open concept living space in gorgeous historic neighborhood and mile-long riverside park 2 blocks from home, 5 minute uber ride to downtown Knoxville, 1 block from an amazing restaurant (Plaid Apron) and coffee shop (Treetop Coffee), dog friendly with fenced in backyard, and large back deck with hot tub! Close to the University of Tennessee campus, World's Fair Park and Downtown Knoxville.

Vacation rentals for every style

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Cabins

Kick off your hiking boots at these rustic lodgings

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A space thats all yours, with room for everyone

Apartments

Convenient locations with everyday essentials

Popular amenities for Knox County guesthouse rentals

Free parking on premises

Air conditioning

Family-friendly guest house rentals

Top guest favorite

The image depicts a serene riverbank, where clear water gently flows over smooth stones. Trees line the bank, their bare branches casting soft shadows on the ground. A grassy area and patches of dirt are visible, suggesting a natural, unspoiled environment.

Guesthouse in Maryville

4.99 out of 5 average rating, 153 reviews

Little River Guesthouse at Wildwood Rd.

Guesthouse in Maryville

4.92 out of 5 average rating, 169 reviews

Relax in a Smoky Mtn getaway near Knoxville

Top guest favorite

A cozy sleeping area features a spacious bed with white linens and several pillows, arranged against warm wooden paneling. Soft wall sconces provide gentle illumination. A decorative mirror is positioned above the bed, reflecting light from a nearby window.

Guesthouse in Knoxville

4.95 out of 5 average rating, 220 reviews

Private North Knox Guesthouse - close to downtown

Top guest favorite

A welcoming living area features a sleek futon and a woven chair, arranged on a patterned area rug. Natural light fills the space through sliding glass doors, which lead to an outdoor deck, framed by lush greenery visible outside.

Guesthouse in Powell

4.99 out of 5 average rating, 228 reviews

Private Guesthouse—serene & conveniently located!

Top guest favorite

A vibrant red exterior is complemented by a dark front door featuring a rooster design. A lantern is mounted beside the door, casting a warm light. Decorative plants are arranged in pots on either side of the entrance, adding charm to the welcoming entryway.

Guesthouse in Knoxville

4.95 out of 5 average rating, 212 reviews

The Chicken Coop city meets country in a cozy spot

Top guest favorite

The exterior of the cottage is displayed, featuring a white facade with large windows and a central door. A slate patio leads to the entrance, framed by decorative plants. A bench is positioned nearby, and a parked trailer is visible on the left.

Guesthouse in Knoxville

4.98 out of 5 average rating, 49 reviews

The Burrow • A Fountain City Cottage

Top guest favorite

A cozy sleeping area features a spacious bed adorned with a lace coverlet. A comfortable sofa and armchair offer seating under the warm glow of two lamps, while a decorative rug adds texture to the wooden floor. Artwork decorates the walls, enhancing the room's charm.

Guesthouse in Oak Ridge

4.98 out of 5 average rating, 395 reviews

The "Tree House" - Privacy, Luxury, Nature Views

The charming cottage is framed by a wooden structure with hanging plants and a grill positioned in the center of a landscaped backyard. Sunlight filters through the trees, casting patterns on the deck, while the cozy exterior hints at a welcoming atmosphere.

Guesthouse in Knoxville

5 out of 5 average rating, 20 reviews

Guest House/Studio 2 miles to downtown

Guest house rentals with a patio

The kitchenette is equipped with a black sink and a small refrigerator. A microwave is positioned on the countertop, with a potted plant and decorative items displayed on the shelves above. Natural light filters through a window, highlighting the warm tones of the cabinetry.

Guesthouse in Knoxville

5 out of 5 average rating, 4 reviews

The Nomad Treehouse | A South Knox Escape

Top guest favorite

A charming exterior view of a light yellow building featuring large sliding glass doors. Surrounded by a landscaped area, decorative planters with blooming flowers are placed by the poolside, and soft string lights are visible along the eaves.

Guesthouse in Seymour

5 out of 5 average rating, 23 reviews

Poolside Oasis at The Salt House

A cozy living area is highlighted by a vibrant orange sofa adorned with a textured pillow. A white coffee table holds a wooden tray displaying decorative items, while a small vase with greenery adds a touch of freshness. A round mirror captures the soft lighting.

Guesthouse in Knoxville

4.53 out of 5 average rating, 182 reviews

Quaint 1-bedroom Studio ~ Walk to Food & Drinks

Top guest favorite

A bright studio features a Queen bed with a colorful quilt and a Full-sized futon that doubles as seating. Large windows invite natural light, complemented by teal curtains. A kitchenette is visible in the corner, along with a small dining table and mat on the floor.

Guesthouse in Knoxville

5 out of 5 average rating, 17 reviews

Casa de Vida of the Smokies

A living area features wooden walls with natural finishes, accompanied by a green three-cushion sofa. A striped accent chair adds color to the space, while a door leads outside. Hooks on the wall display bags, and soft light comes from a nearby lamp.

Guesthouse in Knoxville

New place to stay

La Casita - Cabin vibes.

A charming cabin is set against a serene lake backdrop, featuring a wooden deck and an outdoor dining area with a table and chairs. Lush greenery borders the property, and a decorative wreath adorns the front door, inviting guests to enjoy the peaceful surroundings.

Guesthouse in Louisville

4.94 out of 5 average rating, 47 reviews

Cozy Lake Guest House

Top guest favorite

A wooden deck features a small table with colorful chairs, inviting outdoor seating. The entrance to the cottage includes steps leading up to the deck. The building is surrounded by trees, creating a natural, serene setting.

Guesthouse in Powell

4.96 out of 5 average rating, 50 reviews

Cozy Cottage

The cottage features a charming two-story structure with a pink exterior and white accents. A small balcony is visible above a porch adorned with white furniture. Lush greenery surrounds the home, complemented by garden elements and the contrasting red of a nearby barn.

Guesthouse in Knoxville

Magnolia Cottage

Guest house rentals with a washer and dryer

The spacious living area features a comfortable sofa with patterned throw pillows, a wooden coffee table, and an area rug. A ceiling fan hangs above, and natural light enters through the window with blue curtains. A desk and a mirror are positioned nearby, adding functionality to the space.

Guesthouse in Knoxville

4.8 out of 5 average rating, 51 reviews

Secluded Detached Studio Apartment

Top guest favorite

A charming two-story villa with white exterior walls and decorative details is set against a backdrop of lush green grass. In front, a hen is seen roaming the well-maintained lawn, surrounded by manicured bushes and trees.

Guesthouse in Knoxville

5 out of 5 average rating, 17 reviews

Old Hollywood Charm: Private & Safe Accommodation

Top guest favorite

The exterior showcases a modern brick facade with three large garage doors, allowing for plenty of natural light. Surrounding greenery enhances the tranquil setting, while a spacious driveway offers easy access. The structure is framed by tall trees, providing a serene and peaceful environment.

Guesthouse in Louisville

5 out of 5 average rating, 21 reviews

Forest Hideaway in Louisville

Top guest favorite

A gravel driveway leads to a welcoming colonial-style coach house nestled among trees. The exterior is complemented by a spacious wooden deck and decorative lighting, with a sign indicating 'Coach House' at the entrance. Lush greenery surrounds the property, providing a private atmosphere.

Guesthouse in Heiskell

4.97 out of 5 average rating, 60 reviews

The Coach House

A spacious bed is draped in soft bedding with a textured white throw. A floor lamp provides warm light beside the bed, complemented by framed artwork on the walls. Natural light filters through sheer curtains, enhancing the warm tones of the room.

Guesthouse in Knoxville

4.66 out of 5 average rating, 571 reviews

Hideout 5 min to downtown 🌆 w/ King Bed & driveway

The exterior of the cottage features a rustic dark stone façade and a metal roof. Two large glass doors invite natural light into the space, flanked by potted plants. A gravel pathway leads up to the entrance, surrounded by trees and a wooden fence.

Guesthouse in Rockford

Ivybrook Cottage- 10 miles to downtown Knox!

Top guest favorite

Guesthouse in Knoxville

4.94 out of 5 average rating, 62 reviews

Mini Resort, hot tub & pool, Entire Apartment

Destinations to explore