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Boutique hotel vacation rentals in Appalachian Mountains

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Appalachian Mountains

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A collection of portraits is displayed on a gallery wall. The frames vary in size and style, including ornate gold tones and simpler designs. A small chess set is positioned in the foreground on a dark wooden table, complementing the artful ambiance.
Hotel room in Brookville
4.96 out of 5 average rating, 107 reviews

HALL HOUSE - Master King Bed Suite

Historic Hall House with its distinctive Greek Revival colonnade is listed on the National Register of Historic Places. It is the oldest building in Brookville and has recently been completely restored. Hall House provides upscale hotel-style accommodations with 4 separate guest rooms each with keypad entrance, king or queen bed, fireplace antiques and modern spa bath. There are large common spaces including a Painting Gallery and Sunroom where breakfast is served. (Your hosts live next door.)

Guest favorite
An aerial view captures a vibrant blue hotel surrounded by lush greenery. A large in-ground pool is centered among patio furniture and shaded areas. Several guests can be seen enjoying the pool, which is framed by lounge chairs and umbrellas, enhancing the outdoor relaxation space.
Hotel room in Rehoboth Beach
4.98 out of 5 average rating, 131 reviews

Palm Tree Room - Pool, Hot Tub, Sauna

No kids, no pets. The Palm Tree Room is a spacious luxury bedroom in british colonial style with an ensuite bathroom. The bedroom has a king size bed and seating area with comfy chairs and a desk. Enjoy the large in-ground pool, huge jetted spa/hot tub and Himalayan salt sauna. 10 minutes to the Rehoboth Beach boardwalk, just minutes from a wide array of great dining and 130 outlet stores, a short hop to Cape Henlopen State Park, Lewes, Dewey beach and much more. It's time to hit the beach!

Top guest favorite
An aerial view captures the charming Sandaway Suites & Beach, nestled among lush greenery along the waterfront. The private sandy beach is visible, flanked by a grassy lawn and lounge chairs, while the inviting building showcases multiple gabled roofs and a spacious parking area.
Hotel room in Oxford
4.93 out of 5 average rating, 158 reviews

Water View with Beach, Walk to restaurants & shops

Sandaway Suites & Beach is located in the historic district of Oxford, MD where you can walk to several restaurants and shops. With stunning waterfront views and a private sandy beach on the Eastern Shore of MD rests our boutique hotel. We invite you to stay in one of our beautifully restored water view rooms. Experience in-room comforts and in-town conveniences. Take a day trip to St. Michaels, Easton, or Cambridge. At the end of the day, see an awesome sunset at Sandaway's private beach.

Top guest favorite
Hotel room in New Castle
4.89 out of 5 average rating, 117 reviews

“Pretty In Pink” at the Terry House !

This stylish and unique place sets the stage for a memorable trip. We purchased The Terry House, in January of 2023 and have been renovating the home for the last two years. This room is on the 2nd floor inspired by Jackie Kennedy featuring antique and historic art work. This private room is spacious, with a queen bed as well as private baths and a mini fridge in the room. There is a common area space called the parlor room on the first floor with a Keurig and microwave for you to use.

Superhost
The main house of The Brewery Lodge is set within a lush green landscape, featuring stone and wood architecture. Soft lighting highlights the entrance and surrounding gardens, with a flowering tree providing an inviting focal point amidst the manicured greenery.
Hotel room in Michigan City
4.74 out of 5 average rating, 174 reviews

Brewery Lodge & Supper Club - Stay & Dine Retreat!

Welcome to The Brewery Lodge—an adults-only boutique hotel nestled on 40 wooded acres with flowing streams, quiet ponds, and wildlife. Each of our 12 suites is thoughtfully appointed with peaceful views. The historic 1930 main house features a cozy craft beer and wine lounge with a full-service restaurant and inviting outdoor terraces. With hand-hewn timbers, a stone fireplace, and a warm, rustic feel, it’s the perfect retreat for those seeking comfort, character, and quiet relaxation.

Superhost
The charming exterior of the Buttonwood Boutique Hotel showcases a white wooden façade with black shutters. Two benches are placed in front of the entrance, flanking a welcoming door. Decorative lanterns hang beside the door and potted plants add a touch of greenery.
Hotel room in West Cape May
4.92 out of 5 average rating, 166 reviews

Buttonwood Boutique Hotel - Cottage Suite A

The Buttonwood Boutique Hotel is a wonderful destination for visitors to Cape May! Its convenient location with a short 10 minute walk to the beaches, restaurants, & shopping, coupled with the historic charm & private suites, make it an enticing choice for travelers seeking a memorable experience. The communal spaces provide opportunities for guests to relax & socialize, enhancing the overall atmosphere of hospitality and warmth. You will feel right at home during your stay!

Guest favorite
Hotel room in Wilmington
4.8 out of 5 average rating, 157 reviews

Standard King Room in Lodge near Whiteface

NewVida is a beautiful lodge and restaurant in the Adirondacks at 2000 acres & the close to Whiteface. It has a heartfelt history as Paleface Ski Mtn and has been restored beautifully with an architecturally featured lodge, grand restaurant, cool vibes bar with live music, tapas & billiards lounge, charming bistro, modern gym, wellness center with yoga, massage, & pilates AND 35+ miles of well-established trails for hiking, biking, climbing and private alpine touring.

Superhost
A modern guest room showcases a large bed with a decorative pillow against a graphic wall map of the city. A comfortable gray sofa sits across from it, accompanied by a table featuring a lamp. Natural light enters through a large window.
Hotel room in Chicago
4.8 out of 5 average rating, 207 reviews

Spacious Hotel Room in The Loop

Just steps away from the famed shopping on State Street, this boutique hotel is located inside the Nederlander Theater building in the Chicago Loop Theater District. The hotel features on-site dining, state-of-the-art business services and modern guest rooms with free WiFi. Every room at Cambria Hotel Chicago Loop/Theater District provides a 49-inch flat-screen HDTV and a large work space with a desk and ergonomic chair. Select rooms also offer plush lounge seating.

Top guest favorite
The entrance to The Terry House is framed by a sturdy black door adorned with intricate carvings. A welcoming sign hangs beside the door, and the steps are flanked by neatly trimmed shrubs in black planters, adding an inviting touch to the historic brick façade.
Hotel room in New Castle
4.95 out of 5 average rating, 170 reviews

“Out to Sea” at the Terry House !

The Terry House, a Federal Townhouse circa 1860, is located in historic New Castle, Delaware. This room is on the 2nd floor, featuring a historical nautical theme in one room and historical classic cars in the other room. This suite features, a queen and a full beds as well as private baths and a mini fridge in each room. There is a common area space called the parlor room on the first floor to work, hangout, or play games. ** Not serving breakfast at the moment.

Guest favorite
The well-appointed studio features a plush king-sized bed with a cozy grey blanket, a dining table with black chairs, and a kitchenette with modern appliances. A blue accent wall enhances the space, while large windows provide natural light and views of the surroundings.
Hotel room in Niagara Falls
4.95 out of 5 average rating, 153 reviews

*Walk to Niagara Falls Tourist Area 1 Bedroom Loft

We're your home away from home in the heart of Niagara Falls. Come stay with us at The Cannery Lofts Niagara and feel the energy of our brand-new loft rooms located in a historic, reclaimed 1900s warehouse. Featuring 15-foot ceilings, exposed concrete walls, and modern and spacious bathrooms. This unit features a kitchen including a full-sized refrigerator, convection microwave, and induction cooktop. We provide fresh towels and complimentary toiletries.

Guest favorite
The Library Room features a queen bed with a white coverlet, complemented by dark wood furniture. A decorative area rug enhances the floor, while a ceiling fan provides airflow. A cozy seating area includes a leather chair and a marble fireplace adds warmth, with natural light filtering through the window.
Hotel room in Newport
4.96 out of 5 average rating, 140 reviews

Newport Boutique Hotel w/Parking

Located in the Marshall Slocum Inn, rated 9.4/10 on Booking and Expedia, the room available to rent is the Library Room. The Library Room features a queen bed and private bath with large marbled shower. Bathroom amenities include towels, bath robes, small batch American made shampoo, conditioner, shower gel and hand soap. Air conditioning and individual heat controls in all rooms. Onsite parking is included with all bookings.

Top guest favorite
A neatly arranged bedroom features a spacious bed with a decorative white coverlet. Ornate wooden accents are present, including a fireplace with a patterned surround. Two windows provide natural light, complemented by a desk and chair set near one window. A warm glow is cast by a nearby lamp.
Hotel room in New York
4.84 out of 5 average rating, 113 reviews

The Chester Himes Room at The Harlem Flophouse

Step back in time to the height of the Jazz Age in this meticulously restored 1890s Harlem Brownstone. Famed venues like The Apollo Theater and Paris Blues are steps away, as are restaurants, cafes and museums. Internationally recognized for it's historical charm and simplicity this townhouse has been the site of many fashion and celebrity photo shoots that have included luminaries like Sharon Jones, Neil Patrick Harris and Moby.

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