
House vacation rentals in Seneca
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Top-rated house rentals in Seneca
Guests agree: these houses are highly rated for location, cleanliness, and more.

Clemson Lake House – Game Days & Fire Pit Nights
The perfect home for lake lovers and college football fans. Located just ~5 minutes away from Clemson and Death Valley, the newly renovated lakefront cottage will be the perfect stay for you, your family, and friends. With an outdoor fire pit, amazing views, boat dock, kayaks, and a modern kitchen, this retreat has all the amenities you're looking for inside and out! Whether you spend your time relaxing at the house, cheering on the Tigers, or fishing the lake, the Hideaway is sure to please.

Waterfall Views, Lake Hartwell, Highland Architect
Come and enjoy nature with 100+ acres to roam. Paths for long walks. Architect James Fox designed this cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

Basement apartment in Pendleton w/ sep. entrance
This is a basement apartment in my personal home with its own separate entrance, bathroom, and kitchen. Parking is on the street in front of the house and there’s a concrete walkway that takes you down to the entrance. It’s a studio style apartment with your own thermostat, a king bed, ceiling fans, over 500 sqft, and a fenced backyard for your pup if you bring one. Minutes from Clemson University, T ED Garrison Arena, I85, and 40 min from downtown Greenville. Hulu Live is provided on the tv

Cozy Lake House 5 miles from Clemson w Dock
Only 5 miles from Clemson's campus, this retreat is perfectly situated on almost a full acre. You’ll love the cozy feel, with lots of amenities, including a well stocked kitchen, three-season screened-in porch, & open floor plan. Though the house isn’t directly on the water, our private dock on Hartwell is only a 1-2 min walk away! Nestled between Greenville and the mountains, this home is great for Clemson trips, lake adventures, close night life, restaurants, family entertainment, & more!

Comfort & Convenience Close to Campus
The perfect blend of modern charm and full comfort & convenience just minutes from Clemson, The Pendleton Square and HWY access. You will be sure to have everything you need for your visit. Comfortably sized bedrooms with queen size beds. Spacious living area with cable TV & Netflix. Bright and open kitchen and dining fully equipped for all your cooking needs. Whether you're traveling alone for a little peace & quiet, with friends, or with family... we hope you enjoy your time here!

The Cozy Cottage
Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. The backyard overlooks a peaceful wooded area, providing a serene and private escape. Our home offers the perfect blend of tranquility and convenience. Perfect for getaways, football weekends, graduation, and other Clemson University events!

Hartley’s Haven
Enjoy your stay in this cozy 1 bedroom and 1 bathroom home on Lake Hartwell. We are located 20 minutes from Clemson, 15 minutes to Anderson, and 40 minutes to Greenville, so there is plenty in the area to keep you busy. Located on a dead end street, the neighborhood is very quiet. Our home also has fast wifi and 2 smart TV’s to access any streaming service. We also provide cable. With plenty of parking space in the driveway for vehicles and a boat we can provide a peaceful getaway.

Keowee Key Luxury Condo - Stunning Views!
Freshly renovated condo at the sought after Tall Ship condos in Keowee Key. This is hands down the best unit the complex has to offer with amazing views. Enjoy grilling out on the patio overlooking the marina, walking on the trail, or relax in the pool which is only a short walk away. This is truly a paradise. Guest boat slip is available at the marina for boats or jet skis. Slip is $50 per day. Recommended to book one month in advance.

Shady Rest
As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.

Getaway on Lake Hartwell: Pontoon Rental, Clemson
Our 3 bedroom house is located on Lake Hartwell and is just a 15 min drive to Clemson University. You can enjoy access to the dock and beach which are a quick golf cart ride away. We have paddle boards on the dock and kayaks, coolers, bagged ice, fishing poles etc upon request. Off the back of the detached garage there’s a furnished screened-in deck with a grill that overlooks the end of the cove and fire pit below.

Cozy 3 Br Family Home • 5 min to Clemson Campus
Welcome to your Cozy Family Home! Escape to this charming 3-bedroom, 2-bathroom home, just a short 3-mile drive from the iconic Clemson Memorial Stadium. Whether you're planning a trip to the lake, tailgating for the big game, catching up with friends, or exploring the local hiking trails, this quiet and convenient home is your ideal base. Can't wait for you to enjoy Clemson, SC. Go Tigers! Pet Fee of $100.

The Cottage
Come relax and refresh in peaceful surroundings. Relax and unwind on the front porch. Experience tranquility as the sun sets and the frogs start croaking. You are welcome to cast a line in the pond to try your skill at fishing. Fishing poles are not provided. The cottage is private but still has convenience of Walmart and Oconee Memorial Hospital within a 5 minute drive. We are 13 miles from Clemson.
Popular amenities for Seneca house rentals
House rentals with a pool

Lakeside Family & Dog Retreat Awaits! DWC

Pete's Place

45 Min to Clemson, Lakefront, Dock, Dogs, FirePit

Pet + Family Friendly 4BR Pool House Near Furman

Golf view, lake access, 3 pools!

Open plan living-close to downtown!

Historic peaceful 1906 Farmhouse

New Construction w/ Pool!
Weekly house rentals

Ross Mountain Tiny House - great trail access!

Modern home near Clemson, Keowee

No cleaning fee farmhouse lake keowee near Clemson

Hodge Island Basement Cabin

Unique Retreats at Hartwell

Johnsons Cove - Lakefront Retreat With EV Charger

Cozy Modern Home Close Clemson

3 BR House Near Clemson
Private house rentals

900' of lake front property - 20 min from Clemson

LakeFront+Hot Tub+ Slip Dock+Paddleboards+Kayaks

Forest Getaway 5 mins to Clemson- Private Entrance

A+ Keowee Kustom!*NO Dock!

The Hilltop House near Seneca-Clemson

Point Lot, Boat and PWC Rental

Vacation home 15 mins/Clemson, 7 mins lake Keowee

Deer Creek Farm and Properties, LLC
Quick stats about house rentals in Seneca
Total vacation rentals
Explore 40 vacation rentals in Seneca
Nightly prices starting at
Seneca vacation rentals start at R696 ZAR per night before taxes and fees
Verified guest reviews
Over 1,700 verified reviews to help you choose
Family-friendly vacation rentals
30 properties offer extra space & kid-friendly amenities
Pet-friendly vacation rentals
Find 10 rentals that welcome pets
Rentals with dedicated workspaces
20 properties have a dedicated workspace
Wi-Fi availability
40 of Seneca vacation rentals include wi-fi access
Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Seneca rentals
4.9 Average rating
Seneca stays are highly rated by guests—averaging 4.9 out of 5!
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