
Vacation rentals in Seneca
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Top-rated vacation rentals in Seneca
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Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Seneca vacation rentals
Other great vacation rentals in Seneca

The Cottage upper level
Peter was a great host! His place was immaculate and conveniently located to Seneca and surrounding area. He even left cookies for us. Nice touch!

One Particular Cove ... on Lake Hartwell
We couldn’t be happier with our stay. Perfect size for the 4 of us. Ginny and Sid are wonderful hosts. Our flight was changed and delayed and we didn’t arrive till 3am and had to leave for Clemson graduation by 730am. With little to no time to sleep or eat breakfast they stocked the place with fresh pastries, fruit and bagels and cream cheese. We sadly were only to spend nights at the property so we did t get a chance to take the whole lake location in. I’d go back in a heartbeat

Tee House... waterfront on beautiful Lake Keowee
This was absolutely my favorite AirBnB that i have ever stayed in. Theresa was amazingly resposive and kind! Her property is absolutely breathetaking!! The organization and the cleanliness of her property was 5 star rating, bit the kicker was just the little things here and there that just made you feel like part of the family welcoming you home that really made it special. I will reccomend this property to every one I know going to this area! Thank you Theresa!!!

Renovated Bungalow 1 Block from Downtown Seneca!
The place was exactly what we wanted in value and experience. Entry and exit was so easy, and the two outside spaces were nice options for the morning. We would hope to be able to use this place in the future.

Mountain Road Cottage
Great place to stay and very clean. Esther even had a plate full of cookies waiting on us. Loved it!

South Cove Cottage ~ Lake Keowee
This place was quite cute. We loved the area and spent a lot of time at South Cove County Park. This is by far the nicest park we have seen. We are from Colorado and spent 1 month at South Cove Cottage and love this area.

Near Clemson/Lake Keowee, Firepit, Private
We had another great stay at Cilla's tiny house. It was comforting knowing what we would be arriving to as we got there after midnight. Nice outdoor lighting and easy entry. The outdoor areas are as well maintained as the interior. Recent clearing of brush and fresh mulch on the property surrounding the home/driveway shows how much they care for the property. Cilla leaves lovely personal touches like handwritten notes, local coffee, refreshments and a bag of ice. We wanted for nothing while visiting. Thank you Cilla and Layla!

Lake Daze on Keowee
Was the perfect place for a weekend get away to celebrate our 16 year anniversary! Views were great and the covered dock worked perfect to park our pontoon boat. Would recommend 10/10!!
Quick stats about vacation rentals in Seneca
Total rentals
50 properties
Nightly prices starting at
R721 ZAR before taxes and fees
Total number of reviews
2.1K reviews
Family-friendly rentals
30 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
20 properties have a dedicated workspace
Frequently Asked Questions
Are there vacation rentals with a dedicated workspace in Seneca?
Yes! Work meets play with ease at over 20 vacation rentals in Seneca featuring dedicated workspaces. Stay connected and productive in your home away from home.
How much does it cost to stay in house rentals in Seneca?
Experience the best of Seneca with our house rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there pet-friendly vacation rentals in Seneca?
Four-legged friends are welcome in Seneca. Choose from more than 10 vacation rentals for guests traveling with pets.
Do house rentals in Seneca have wireless internet?
Absolutely! We offer over 30 house rentals with wireless internet in Seneca. Enjoy a tailored experience with all the comforts you desire.
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- Black Rock Mountain State Park
- Gorges State Park
- Table Rock State Park
- Tallulah Gorge State Park
- Mountaintop Golf & Lake Club
- Helen Tubing & Waterpark
- Bell Mountain
- Tugaloo State Park
- Jump Off Rock
- Don Carter State Park
- Wade Hampton Golf Club
- Anna Ruby Falls
- Victoria Bryant State Park
- Old Edwards Club
- Funopolis Family Fun Center
- Ski Sapphire Valley
- Discovery Island
- Carl Sandburg Home National Historic Site
- Haas Family Golf
- Louing Creek
- Victoria Valley Vineyards