Vacation rentals in Pine Island

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Pine Island

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite

A garden-level apartment is accessed via a gravel driveway that leads to a charming home. Lush greenery surrounds the path, and the structure features a mix of siding colors, with large windows framed by blue shutters, creating an inviting exterior appearance.

Apartment in Rochester

Woodland Retreat, Full private walkout lower level

Peaceful retreat down gravel driveway 15 min from Mayo Clinic. Enjoy your own apartment with private backyard walkout entrance to the lower level of our home. You will have a bedroom, living area, kitchenette with mini fridge, microwave and toaster oven (no conventional stove/oven), bathroom w/ tub & shower, pingpong table, laundry, and patio with fire ring. You may hear piano music weekday afternoons, since I give lessons (usually 3-6 pm; a bit earlier in summer) NEW HEATED FLOORS w/thermostat

4.95 out of 5 average rating, 259 reviews

Top guest favorite

Apartment in Rochester

Restful sanctuary close to Mayo Clinic

This cozy space has private, self-entrance with off-street parking at no cost...a mere 2.5 miles or 10 minute drive to the Mayo Clinic downtown. Located in a quiet neighborhood in NW Rochester. Easy access to highways, grocery store, coffee shop/cafes, Target, and walking trail. Completely furnished with linens, Netflix and Hulu, Wi-fi, and coffee maker. The laundry is shared with the host; who resides in the upper level. Please, no large construction vehicles. Truly a home away from home!

4.97 out of 5 average rating, 282 reviews

Top guest favorite

A serene view of a well-maintained lawn leading to a calm lake, framed by trees. A stone-edged garden bed with varied foliage is visible in the foreground. The water glistens under sunlight, and a dock is seen in the distance, enhancing the peaceful lakeside setting.

Home in Zumbro Falls

Zumbro Lake Home

Relax with the whole family, plan an ice fishing trip with your buddies, or enjoy the lake between clinic appointments. Large lawn with 160ft lake front perfect for swimming, kayaking, fishing, or just relaxing by the water. Full kitchen, laundry, 2 full bathrooms, 2 bedrooms, 2 queen beds and twin bunkbeds in the main house. A second, separate building referred to as the "Bunkhouse" features 3 double beds upstairs and a 2 double beds in the lower level. Within 20 minutes of the Mayo Clinic.

4.95 out of 5 average rating, 43 reviews

Top guest favorite

A cozy seating area features a gray sofa and two armchairs with decorative cushions. A round coffee table sits in the center, accompanied by a plush area rug. A large TV displays a calming nature scene, while soft natural light filters through sheer curtains.

Home in Rochester

Home Calls the Heart- 10min to Mayo

1/2 block from HWY 52, serene and peaceful split level home. 10 min to Mayo Clinic & St. Mary's Hospital. Fully furnished, convenient and ideal for families & professionals for the home away from home feel. Luxury Sheets and Posturepedic . Fully equipped with various kitchen appliances and utensils. Minutes to parks, groceries, shopping etc. Wifi, Roku Smart TV & cable. Phone call away if you have any issues while staying at our charming home. No pets due to Mayo Clinic guests’ allergies.

4.93 out of 5 average rating, 305 reviews

Top guest favorite

A well-maintained house with a stone and siding exterior is shown, featuring large windows that allow natural light. A welcoming front porch with planters is complemented by a manicured lawn and a two-car garage on the side. Green shrubs enhance the property's appeal.

Home in Rochester

Quiet Stay by Lake, Near Mayo, Fireplace, King Bed

Beautiful house with 4 bedrooms, 2 bathrooms in the peaceful neighborhood. 2 miles from Mayo Clinic. 3 bedrooms on main floor, fully equipped modern kitchen; spacious family rooms; washer dryer on site; attached two car garage; fenced yard to provide privacy and serenity. Convenient access to shopping centers and restaurants. two minutes walk to silver lake with benches, picnic area and walking path. Please note that the price you pay includes 15.125% local taxes, 15.5% Airbnb service fees.

4.98 out of 5 average rating, 121 reviews

Top guest favorite

Home in Rochester

New! MN Comforts The Heart 4Bd/2Bth, 12min to Mayo

Welcome to MN Comforts The Heart! Are you here for work or leisure, or want to feel comforted after a Mayo appts? 12 min to Mayo Clinic, Wifi, work-station, ROKU/Smart TVs, and a fireplace in the family room. We offer a 2nd home feel. Near stores. Split-level, chill, and quiet, thoughtfully designed to cater to your needs, ensuring a comfortable, enjoyable stay. A blend of traditional & modern styling in a tranquil home, with fun opportunities for family & friends. Fully fenced backyard.

5.0 out of 5 average rating, 103 reviews

Top guest favorite

A welcoming book titled 'Welcome to Oasis' is displayed prominently, featuring a lotus flower design and neatly placed beside a decorative white vase. Greenery is visible in the background, adding a touch of nature to the inviting setting.

Home in Rochester

Oasis - Comfort & Serenity (Full house near Mayo)

*Discount for extended stays* Seeking a peaceful respite near Mayo Clinic in Rochester, MN? Look no further than "Oasis"–your ultimate home away from home. We offer 5 beds, 2 baths, & can accommodate up to 8 guests. Recharge in the workout & yoga meditation room, stay connected in the office area, & explore Rochester's attractions. Your dedicated host Peggy, a Mayo employee, will ensure a seamless/enjoyable stay. Book now & experience the perfect blend of comfort & serenity at Oasis.

4.95 out of 5 average rating, 153 reviews

Top guest favorite

Home in Rochester

Near Mayo Family Friendly / 5 beds 2 baths CLEAN

Nestled in the cul-de-sac of Arcon Lane in the northwest side of Rochester, Minnesota, an Airbnb was established in the summer of 2025. It was given a name called Arcon Hollow B&B. Arcon Hollow B&B can be whatever space you’d like it to be for your stay. It can be your peace and quiet space away from the chaos of life, your rest and restore atmosphere to renew your energy, or your home away from home for different reasons that bring you to our beautiful town Rochester, Minnesota.

4.98 out of 5 average rating, 55 reviews

Top guest favorite

Home in Rochester

Luxurious 5-BR Retreat with Gym & Game Area

Welcome to Bella Retreat! Our five-bedroom home, constructed in 2023, is thoughtfully designed to cater to your every need, ensuring a comfortable and enjoyable stay. You'll discover modern amenities and a tranquil atmosphere, along with opportunities for family fun. Whether you're here for work or leisure, or if you simply want to relax while visiting the Mayo Clinic, we invite you to experience the perfect blend of luxury, convenience, and entertainment in our stylish home.

5.0 out of 5 average rating, 101 reviews

Guest favorite

The cabin is positioned along the water's edge, surrounded by lush greenery. A dock extends into the lake, accompanied by a small boat. A spacious deck with steps leads up from the shoreline, providing an inviting space for relaxation.

Cabin in Zumbro Falls

Our Happy Place

Welcome to our happy place. Forget your worries in this spacious and serene space. Enjoy the views and the company on the deck. You will be steps from the water where you can catch some rays or fish off the dock. Unwind at our cozy cabin with the convenience of being 20 min away from Rochester. Take in some live music or people watching at any of the 3 bars on the lake, all a short driving distance away. Boat rentals are also available at Kings Marina.

4.94 out of 5 average rating, 17 reviews

Top guest favorite

A modern home features a light-colored exterior with stone accents. The front entrance is marked by a wide staircase leading to double doors. Lush green grass surrounds the driveway, which leads to a two-car garage. A tree stands nearby, enhancing the outdoor space.

Home in Rochester

St. Augustine’s Family Home ❤️ GARAGE!!

Wonderful clean, newer home located in the fast growing NW Rochester. The home is the perfect set up for large families. Recliner! 2 bedrooms and 2 bath located upstairs on main level, 2 bedroom and bath located downstairs.. The home is well equipped, comfortable, and clean. Smart Tv and fast WiFi!!! 2 car garage and snow service included!! Restaurants, playgrounds, salons, bars, breweries, movie theatre, and shopping minutes away!!

4.93 out of 5 average rating, 138 reviews

Top guest favorite

Home in Rochester

The Sierra! Close to Mayo Clinic

Gorgeous Home close to Mayo Clinic. The family room and living include Roku 4K UHD TVs, Foosball, and darts. Free WIFI. Office on Main with great light. Beautiful front porch or patio in the rear. TVs Enjoy luxurious finishes like crown molding, a fireplace in the family room, quartz countertops and a stunning vaulted Primary Ensuite with custom tile work and paneled doors. All of this is conveniently just minutes from downtown!

4.97 out of 5 average rating, 206 reviews