
House vacation rentals in La Mesa
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Top-rated house rentals in La Mesa
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XTRA 10% OFF until Nov: Pool, outdoor fire pits, c
Find your family's dream spot in San Diego! Our cozy house sits on a quiet hill, offering privacy and amazing sunset views. Dive into our pool year-round (heating at an additional cost), roast marshmallows by the fire, and cook up fun meals together. With 3 bedrooms and 2 bathrooms, it’s perfect for families, accommodating up to 9 guests. Plus, we're close to all the best attractions. Want a vacation you'll always remember? Send us a message to make it happen! 🌅🏠 We have 3 comfy beds that can

Hidden King Suite with Garden, Parking - 4 Guest
Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Designer Luxury Rental With Pool
Welcome to Wander Haven, a luxury central rental. With it’s on trend design, custom built stock tank pool, array of amenities and thoughtful touches throughout, you won’t ever want to leave. But when do you do decide to venture out and explore all that beautiful San Diego has to offer, you will find the central location gets you to anywhere you want to be in minutes. You’re 15 minutes or less from beaches, downtown, balboa park, sea world, the zoo and hundreds of amazing bars and restaurants.

Golden Hill Tree House
The Golden Hill Tree House is an urban oasis hiding in the branches of two mature trees in the heart of San Diego. While you enjoy elevated privacy you can also treat yourself to a soaker tub with double shower heads or settle down in a cozy reading nook to enjoy a good book! You'll also be walking distance to some amazing restaurants and super close to the best of San Diego, including downtown, the beach and the zoo! It's a perfect place to recharge after a long day of business or pleasure!

Sunny & Spacious 3BR Retreat w/ Parking & A/C
Centrally located in La Mesa is this newly refurbished home ideal for business or pleasure with all of life’s little luxuries waiting for you to enjoy. The home features open concept living with a gourmet kitchen, a chic dining space, 3 beautiful bedrooms, 2 modern bathrooms and an expansive yard with an outdoor lounge. Walk 10 mins to Grossman Center with a Target, restaurants, cafes, a cinema & Walmart or drive to the heart of San Diego and all its attractions just 20 mins from your door.

Travel Writer's Pad
Hello, Bonjour, Hola, Ciao, Ni Hao! For the past two decades my career as a travel journalist has taken me around the globe. I’ve stayed at thousands of accommodations, where I learned personal touches create a comfortable home away from home. Certain places I visited offered extra special amenities, such as Green tea at a Japanese Ryokan & chardonnay infused bath salts at a Mexican posada. These kinds of touches are in the home. I welcome you, but no parties or events at the house. Thanks!

Clean 1BR/1BA Guest House Peaceful Private Casita
Discover the perfect home away from home in San Diego! Our cozy and tranquil guest house is located just a short drive from the city's top attractions, including the San Diego Zoo and beautiful beaches. Relax and unwind in the comfortable living room and enjoy all the amenities you need for a peaceful stay. With a comfortable queen-sized bed, full kitchen, and fresh towels, you'll have everything you need to feel at home. Book your stay with us today and experience the best of San Diego!

Cottage in the Garden! New! Modern!
COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Zen Retreat: 3-Bedroom Oasis near La Mesa Village
Relax in this charming 3-bedroom, 1-bathroom home located just 1 mile from the heart of Historic Downtown La Mesa Village. Nestled in a quiet, central neighborhood, this cozy retreat offers easy access to major freeways, top-rated restaurants, and the local trolley line making it a breeze to explore the best of San Diego. Within 10 to 15 miles, you’ll find yourself in iconic destinations like Downtown San Diego, Balboa Park, Coronado Island, scenic beaches, and beautiful mountain trails.

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub
Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

(Relist!) Relax at a Stunning 1931 Historic Tudor!
Come & enjoy our 1931 historic tudor home! Beautifully rebuilt within the last 2 years. This house has a huge front lawn and space to roam. Enjoy the serenity this large property has to offer. Three peaceful patios to enjoy your morning coffee. The kitchen has an 48-inch 1950’s oven for the chef in the family. Bay windows, arched entryways and original light fixtures make this such a charming place to stay. Centrally located to enjoy everything San Diego & La Mesa has to offer.

Stylish 1Br Retreat: Parking AC Close 2 Everything
HIGHLIGHTS -Close to SD's main attractions -Stylish and comfy interior w/great lighting -Quaint, walkable neighborhood -Fully renovated kitchen w/new appliances -A/C -Washer/Dryer -Courtyard Patio -1 large, reserved parking spot Enjoy top tier restaurants, cafes and shops along vibrant Adams Ave or explore San Diego’s major attractions less than 15 min away. Downtown for Gaslamp; Balboa Park for museums and Zoo; SDSU for events and games; Mission Beach for fun in the sun.
Popular amenities for La Mesa house rentals
House rentals with a pool

3BR Urban Oasis - Pool and Hot Tub | San Diego

The Queen House

Casa Bahia Beautiful San Diego Home with Pool

Sunny SD l Pool l BBQ l Pool Loungers l Sleeps 10

University Heights Oasis Getaway

Mid-Century Modern and Contemporary House

Updated TownHome, Great Location, Fantastic Views

Upscale Resort House /Views, Saltwater Pool/Spa !
Weekly house rentals

Airbnb Luxe: The Perfect Blend of Access & Escape

Cozy 1BR Home with Lovely Front Yard

Discover La Mesa: Your Perfect Cozy Base

Helix Haven

Modern, Private, & Stylish Home

Chic Casita•Hot tub•BBQ•Patio•4 min SDSU•CentralSD

Entire house, fenced yard, and driveway

Luxury Hilltop Getaway • Scenic Views
Private house rentals

A Perfect Pet Friendly Getaway.

Serenity in San Diego

Jamul Hacienda | Couples Retreat | Pool & Views!

Garden Retreat in North Park.

Cozy quiet getaway, great mattress (1-br)

San Diego's Finest Retreat

XLarge Artist's Retreat w/private patio/parking

Cozy Mid-Century Charmer | Huge Backyard | Firepit
When is the best time to visit La Mesa?
Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Avg. price | R3,119 ZAR | R3,119 ZAR | R3,311 ZAR | R3,137 ZAR | R3,207 ZAR | R3,729 ZAR | R3,817 ZAR | R3,712 ZAR | R2,963 ZAR | R3,189 ZAR | R3,119 ZAR | R3,363 ZAR |
Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Quick stats about house rentals in La Mesa
Total vacation rentals
Explore 300 vacation rentals in La Mesa
Nightly prices starting at
La Mesa vacation rentals start at R349 ZAR per night before taxes and fees
Verified guest reviews
Over 13,300 verified reviews to help you choose
Family-friendly vacation rentals
190 properties offer extra space & kid-friendly amenities
Pet-friendly vacation rentals
Find 100 rentals that welcome pets
Vacation rentals with a pool
80 properties feature pools
Rentals with dedicated workspaces
180 properties have a dedicated workspace
Wi-Fi availability
300 of La Mesa vacation rentals include wi-fi access
Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across La Mesa rentals
4.9 Average rating
La Mesa stays are highly rated by guests—averaging 4.9 out of 5!
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