La Mesa vacation rentals

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Top-rated vacation rentals in La Mesa

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in La Mesa

4.97 out of 5 average rating, 129 reviews

Da Hui Hut-Beachy home/La Mesa’s best view and spa

Da Hui Hut is a very private oasis uniquely situated at the top of San Diego county's magnificent Mt. Helix. At roughly 1,300 feet above sea level, Mt. Helix is the crown jewel of natural landmarks in the area. The landscape provides bountiful views, and the large deck is positioned perfectly to see it all. It feels like you're on top of the city! Inside, guests will encounter Californian and Hawaiian inspired decor as they collide with wooden walls to compose a symphony of color and good vibes.

Oct 4 – 11

R3,221 ZAR per night

Guest favorite

Guesthouse in La Mesa

4.92 out of 5 average rating, 205 reviews

Fig Tree Bungalow

Enjoy your stay in San Diego in this newly renovated guesthouse. Centrally located about a mile from Hwy 8, Hwy 125, and the Grossmont Trolley Station & Transit Center. Only a 15-20 minute drive to downtown, the airport, the beaches, and most of San Diego's other popular tourist attractions. This cozy, two-story, detached unit is located behind my home, and has its own private entrance and partitioned yard for your enjoyment. There's plenty of street parking directly in front of the house.

Aug 17 – 24

R2,359 ZAR per night

Guest favorite

Guest suite in La Mesa

4.91 out of 5 average rating, 108 reviews

Stylish Boho Studio | Walk to Cafes | Outdoor Living

The studio is located within a quiet leafy neighborhood right in the heart of La Mesa giving you a great base to explore everything San Diego has to offer. Inside you will find a bright, sun-filled space with a chic kitchen, an open plan living/dining area with a comfortable sofa bed, a stylish queen bedroom and a modern, sparkling bathroom with a built in laundry. Stay a short 15 min walk to a shopping center nearby with cafes, restaurants and stores and an easy 15 min drive into Downtown.

Nov 17 – 24

R2,951 ZAR per night

Guest favorite

Home in La Mesa

4.85 out of 5 average rating, 176 reviews

Newer "Manor Studio"

Centrally located in San Diego County this brand new studio style unit has a private entrance, private patio area and street parking. Furnished with a queen size bed, love seat, full bathroom and kitchen area. One large drawer to accommodate personal items, and a wall rack to hang clothing. There is a smart TV with WiFi streaming capabilities and lots of USB plugs to charge your devices. On street parking in front of unit (no parking in driveway). No Pets allowed. No Hair Dying allowed.

Jul 13 – 20

R2,196 ZAR per night

Guest favorite

Guesthouse in La Mesa

4.97 out of 5 average rating, 167 reviews

Cozy Coop with a View

This house is perfect for a private get away. There is a patio bar & a large picture frame window that commands the best views in the area. Sit & enjoy the large patio right off the entryway to the house. I have been told our home used to be a chicken coop in the 50-60's. It is far different now, we just finished a complete remodel. Everything is updated, upgraded & ready for you. Being on the top of the hill you get the nice views, but sounds carries as well, please respect the neighbors.

May 12 – 19

R2,813 ZAR per night

Guest favorite

Home in La Mesa

4.93 out of 5 average rating, 177 reviews

Cottage in the Garden! New! Modern!

COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Nov 5 – 12

R2,787 ZAR per night

Guest favorite

Home in La Mesa

4.99 out of 5 average rating, 118 reviews

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Jul 7 – 14

R2,334 ZAR per night

Guest favorite

Barn in La Mesa

4.95 out of 5 average rating, 315 reviews

Enchanting Barn San Diego/La Mesa

DESCRIPTION: Relax and Enjoy the converted barn that is safe, cozy, and private. The unit has it's own private entrance secured with a Keyless entry lock. Inside is a Cal King therapy foam bed, TV, Blu-ray player, Bluetooth/CD stereo, and additional USB connection. Extra space has a large desk area. The unit has a private bathroom that includes a walk in shower. Freshly washed towels & linens are provided. *we have a pet goat that would love to meet you! Dedicated 5g Internet access

Oct 4 – 11

R2,030 ZAR per night

Guest favorite

Guest suite in La Mesa

4.91 out of 5 average rating, 114 reviews

Private & cozy getaway 8min from downtown SD

One bedroom guest house in La Mesa/San Diego with private entry. Also, have an inflatable queen air mattress for another 1-2 sleepers. The two rooms are divided and can be separated with a sliding door and blackout curtains. You got all the basic amenities that you would need such as a mini fridge, keurig coffee maker, smart TV, central heat & AC. Prime location! Only 8 minutes from downtown SD. Come enjoy a memorable stay that has easy access to nearby beaches, nightlife and shopping.

Aug 28 – Sep 4

R2,111 ZAR per night

Guest favorite

Apartment in La Mesa

4.98 out of 5 average rating, 122 reviews

Lovely Hideaway Studio by Village-Private Patio

Enjoy the cool vibe at this unique rustic getaway tucked back on a tree-lined hill 5 minutes above City of La Mesa Village, 20 minutes from downtown San Diego. The studio is on the ground floor of our two-story house. We live on the 2nd floor, and the studio is it's own completely private space. 5 miles to San Diego State University; 16-20 miles to San Diego beaches; 10 miles to Downtown San Diego; 15 miles to Sea World San Diego; and 13 miles to the World Famous San Diego Zoo!

Mar 10 – 17

R1,948 ZAR per night

Guest favorite

Guesthouse in La Mesa

4.99 out of 5 average rating, 131 reviews

Stunning Guest House 15 min. from Zoo, Downtown

Stunning guest house that's 15 minutes to San Diego Zoo + downtown San Diego and 18 minutes to a beach. Unique private property with mid-century and one-of-a kind furniture in a comfortable living space. Enjoy IPAs on your private deck or coffee in bright Fiesta cups, watch TV while leaning back in the handcrafted Nicaraguan rocker or the 1950s Danish slipper chair. The cottage also has a comfy queen-sized bed. Like eclectic? This place exudes it.

Sep 15 – 22

R3,051 ZAR per night

Guest favorite

Apartment in La Mesa

4.97 out of 5 average rating, 139 reviews

Mt. Helix apartment with panoramic views

Mt. Helix apartment with great views from private balcony located centrally in La Mesa on quiet street. Apartment is on 2nd floor of private home on an acre lot. PLEASE NOTE: Apartment is on 2nd floor and an outside staircase is required to enter the apartment. 1 parking space is designated in driveway. Quiet Hours are 10:00pm - 7:00am. No smoking/vaping anywhere on the property.

Aug 31 – Sep 7

R2,057 ZAR per night

Vacation rentals for every style

Get the amount of space that is right for you

Popular amenities for La Mesa vacation rentals

Gym

BBQ grill

Laptop-friendly workspace

Wifi

Air conditioning

Stay near La Mesa's top sights

Grossmont Center48 locals recommend

Mt. Helix Park92 locals recommend

Trader Joe's52 locals recommend

Lake Murray Community Park11 locals recommend

DZ Akins24 locals recommend

La Mesa Springs Shopping Center7 locals recommend

Other great vacation rentals in La Mesa

Guest favorite

Cottage in La Mesa

4.97 out of 5 average rating, 277 reviews

La Mesa House On a Hill With Mountain Views!

Sep 5 – 12

R3,033 ZAR per night

Guest favorite

Guesthouse in La Mesa

4.97 out of 5 average rating, 117 reviews

San Diego Newly Built Private Guesthouse (Sleep 5)

Nov 15 – 22

R2,747 ZAR per night

Guest favorite

Guest suite in La Mesa

4.9 out of 5 average rating, 172 reviews

Charming Suite in Historic Home

Sep 20 – 27

R2,605 ZAR per night

Guest favorite

Guesthouse in El Cajon

4.98 out of 5 average rating, 190 reviews

Fletcher Hills - modern 1 BR.Easy, no step access.

Mar 19 – 26

R2,255 ZAR per night

Guest favorite

Bungalow in La Mesa

4.93 out of 5 average rating, 191 reviews

Two bedroom garden bungalow in West La Mesa

Oct 3 – 10

R2,895 ZAR per night

Guest favorite

Apartment in La Mesa

4.94 out of 5 average rating, 287 reviews

A Little Bit of Luxury in La Mesa! Private & Gated

Sep 4 – 11

R3,015 ZAR per night

Guest favorite

Guesthouse in San Diego

4.91 out of 5 average rating, 113 reviews

Charming Granny Flat Near SDSU & Transit Center

Jun 4 – 11

R2,520 ZAR per night

Guest favorite

Guest suite in La Mesa

4.86 out of 5 average rating, 104 reviews

Cozy Unique Studio/One Bedroom Gem

Jan 6 – 13

R2,465 ZAR per night

Show all

Other great vacation rentals in La Mesa

Guest favorite

Tiny home in La Mesa

5.0 out of 5 average rating, 96 reviews

Casita de Pueblo - Private Yard, La Mesa Village

Feb 20 – 27

R2,527 ZAR per night

Guest favorite

Guest suite in La Mesa

4.98 out of 5 average rating, 62 reviews

Cozy Casita is a Peaceful, Private, Safe Studio

May 6 – 13

R1,915 ZAR per night

Guest favorite

Guesthouse in La Mesa

5.0 out of 5 average rating, 40 reviews

Beautiful Bright Mt. Helix Studio

Mar 25 – Apr 1

R2,522 ZAR per night

Guest favorite

Guesthouse in La Mesa

5.0 out of 5 average rating, 16 reviews

NEW construction - Studio

Sep 11 – 18

R2,114 ZAR per night

Guest favorite

Guesthouse in La Mesa

5.0 out of 5 average rating, 61 reviews

Private 1 BR Paradise retreat

Apr 3 – 10

R2,447 ZAR per night

Guest favorite

Guest suite in La Mesa

5.0 out of 5 average rating, 34 reviews

Emerald King Wellness Suite w/ Sauna & Workspace

Sep 8 – 15

R2,661 ZAR per night

Guest favorite

Guest suite in La Mesa

4.87 out of 5 average rating, 82 reviews

La Mesa Granny Flat

Dec 14 – 21

R2,134 ZAR per night

Guest favorite

Guesthouse in La Mesa

5.0 out of 5 average rating, 32 reviews

Sunny La Mesa Hilltop Cottage

May 25 – Jun 1

R2,704 ZAR per night

Show all

Quick stats about vacation rentals in La Mesa

Total rentals
510 properties
Rentals with dedicated workspaces
310 properties have a dedicated workspace
Rentals with a pool
140 properties have a pool
Pet-friendly rentals
170 properties allow pets
Family-friendly rentals
250 properties are a good fit for families
Total number of reviews
23K reviews

Frequently Asked Questions

Are there pet-friendly vacation rentals in La Mesa?
Four-legged friends are welcome in La Mesa. Choose from more than 170 vacation rentals for guests traveling with pets.
Are there vacation rentals with a dedicated workspace in La Mesa?
Yes! Work meets play with ease at over 310 vacation rentals in La Mesa featuring dedicated workspaces. Stay connected and productive in your home away from home.
Are there La Mesa vacation rentals on Airbnb with pools?
Yes! Dive into the perfect getaway at one of over 140 vacation homes with pools in La Mesa, available on Airbnb. Make a splash and soak up the sun in style!
Do house rentals in La Mesa have a bbq area?
Absolutely! We offer over 70 house rentals with a bbq area in La Mesa. Enjoy a tailored experience with all the comforts you desire.
Do house rentals in La Mesa have a gym?
Absolutely! We offer over 30 house rentals with a gym in La Mesa. Enjoy a tailored experience with all the comforts you desire.
How much does it cost to stay in villa rentals in La Mesa?
Experience the best of La Mesa with our villa rentals, starting at about $50 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there family-friendly house rentals in La Mesa?
La Mesa has more than 190 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
Do private suite rentals in La Mesa have wifi?
Absolutely! We offer over 40 private suite rentals with wifi in La Mesa. Enjoy a tailored experience with all the comforts you desire.
Do apartment rentals in La Mesa have air conditioning?
Absolutely! We offer over 30 apartment rentals with air conditioning in La Mesa. Enjoy a tailored experience with all the comforts you desire.
What are the most popular amenities for Private Suite Rentals in La Mesa?
Enhance your stay in our Private Suite Rentals with the most popular amenities: over 10 homes with a gym, over 40 homes with air conditioning, over 40 homes with wifi, and more. Indulge in the ultimate retreat, tailored to your preferences.

La Mesa vacation rentals

Top-rated vacation rentals in La Mesa

Vacation rentals for every style

Apartments

Houses

Hotels

Popular amenities for La Mesa vacation rentals

Stay near La Mesa's top sights

Other great vacation rentals in La Mesa

Cottage in La Mesa

Guesthouse in La Mesa

Guest suite in La Mesa

Guesthouse in El Cajon

Bungalow in La Mesa

Apartment in La Mesa

Guesthouse in San Diego

Guest suite in La Mesa

Other great vacation rentals in La Mesa

Tiny home in La Mesa

Guest suite in La Mesa

Guesthouse in La Mesa

Guesthouse in La Mesa

Guesthouse in La Mesa

Guest suite in La Mesa

Guest suite in La Mesa

Guesthouse in La Mesa

Quick stats about vacation rentals in La Mesa

Total rentals

Rentals with dedicated workspaces

Rentals with a pool

Pet-friendly rentals

Family-friendly rentals

Total number of reviews

Frequently Asked Questions

Are there pet-friendly vacation rentals in La Mesa?

Are there vacation rentals with a dedicated workspace in La Mesa?

Are there La Mesa vacation rentals on Airbnb with pools?

Do house rentals in La Mesa have a bbq area?

Do house rentals in La Mesa have a gym?

How much does it cost to stay in villa rentals in La Mesa?

Are there family-friendly house rentals in La Mesa?

Do private suite rentals in La Mesa have wifi?

Do apartment rentals in La Mesa have air conditioning?

What are the most popular amenities for Private Suite Rentals in La Mesa?

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