Guesthouse vacation rentals in James Island
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Top-rated guesthouse rentals in James Island
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for James Island guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 213 reviewsBungalow Under The Oaks
Sep 21 – 28
Guesthouse in North Charleston
4.94 out of 5 average rating, 346 reviewsCozy Park Circle, Charleston Guest House
Aug 20 – 27
Guesthouse in Charleston
4.93 out of 5 average rating, 316 reviewsCozy Island Cottage
Jun 5 – 12
Guesthouse in Summerville
4.98 out of 5 average rating, 642 reviews★Delightful guest house near historic plantations★
Jan 25 – Feb 1
Guesthouse in North Charleston
5.0 out of 5 average rating, 110 reviewsThe Park Circle Clerestory Studio Guest House
Jun 20 – 27
Guesthouse in Johns Island
4.98 out of 5 average rating, 238 reviewsPrivate waterfront apt in the oaks
Dec 28 – Jan 4
Guesthouse in Charleston
4.83 out of 5 average rating, 109 reviewsRomantic Beach Style Cottage close to everything!
Apr 4 – 11
Guesthouse in North Charleston
4.86 out of 5 average rating, 441 reviewsPark Circle Jungalow Loft
Aug 7 – 14
Guest house rentals with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 120 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Sep 12 – 19
Guesthouse in Charleston
4.97 out of 5 average rating, 125 reviewsStudio Apartment Minutes to Downtown Charleston
Apr 13 – 20
Guesthouse in Johns Island
4.91 out of 5 average rating, 104 reviewsCozy Cottage! 5 mins from Kiawah!
Oct 7 – 14
Guesthouse in Charleston
4.98 out of 5 average rating, 45 reviewsCountry in the City, "The Outback"
Apr 16 – 23
Guesthouse in Charleston
5.0 out of 5 average rating, 23 reviews1/1 sleeps 3 ADU Modern+Amazing!
Jul 9 – 16
Guesthouse in Charleston
5.0 out of 5 average rating, 12 reviewsGas Light Carriage House James Island
Aug 22 – 29
Guesthouse in Charleston
4.95 out of 5 average rating, 40 reviewsGuest suite in Charleston
Apr 13 – 20
Guesthouse in Charleston
5.0 out of 5 average rating, 72 reviewsLuxury Loft (2 miles from Folly Beach)
Mar 12 – 19
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.98 out of 5 average rating, 106 reviewsCharleston Casita near Folly Beach *Dog Friendly*
Jan 31 – Feb 7
Guesthouse in Charleston
4.96 out of 5 average rating, 236 reviewsUnique Hidden Gem w/ Luxury Shower Near Folly & DT
Aug 5 – 12
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 405 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Apr 10 – 17
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 222 reviewsCozy Apartment in Mount Pleasant
Feb 18 – 25
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Jan 23 – 30
Guesthouse in Charleston
4.99 out of 5 average rating, 204 reviewsRedesigned suite! 12min to city, pet-friendly
Dec 11 – 18
Guesthouse in Charleston
4.99 out of 5 average rating, 140 reviewsLarge Guesthouse with Private Dock & Marsh Views
Sep 2 – 9
Guesthouse in Charleston
4.9 out of 5 average rating, 547 reviewsCute, Cozy, Charleston Cottage
Aug 31 – Sep 7
Destinations to explore
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- Rentals with a patio James Island
- Rentals with a fireplace James Island
- Waterfront rentals James Island
- Pet-friendly rentals James Island
- Private suite rentals James Island
- Rentals with outdoor seating James Island
- Rentals with a fire pit James Island
- Beachfront rentals James Island
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- Rentals with an EV charger James Island
- Rentals with beach access James Island
- Apartment rentals James Island
- Rentals with a washer and dryer James Island
- Kid-friendly rentals James Island
- Rentals with pools James Island
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- Rentals with a hot tub James Island
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- Monthly Rentals James Island
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