House vacation rentals in St. Charles County

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Top-rated house rentals in St. Charles County

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 314 reviews

Maison Charbonneau Near Old Town

Winner of Airbnb's "Top New Host in Missouri" award for 2021, La Maison Charbonneau is a stylishly renovated century-old, 2500 sq ft home near Historic OldTown StCharles and Frenchtown. Sit on the porch swing and listen to the bells of Borromeo Cathedral, relax in our comfortable furnishings, enjoy movies and popcorn in our personal theater, use our full kitchen, dining room to make family meals, or take a walk through nearby bricked streets to restaurants, coffee shops, shopping, and the cinema

Sep 8 – 15

R3,860 ZAR per night

Guest favorite

Home in Saint Charles

4.97 out of 5 average rating, 192 reviews

*HotTub* The Jewel on 5th-2br2b-near Historic Main

A true gem 15 mins from St Louis Lambert Airport-enjoy a well equipped, century home with a short walk to Historic Main and a HOTTUB. The large stocked kitchen is great for entertaining. Master bedrm w/luxurious, king sized, 4 poster bed and ensuite bathrm awaits you. In the private, queen suite you’ll find its own bathrm and another door leading onto the deck. The chair off the kitchen folds out to a standard twin and bedding is provided for the sofa as well. This charming jewel accommodates 6.

Jul 25 – Aug 1

R4,864 ZAR per night

Guest favorite

Home in Kirkwood

4.98 out of 5 average rating, 176 reviews

A Kirkwood Cottage, Quaint Suburb of St Louis

Quaint cozy cottage on a “No Thru Street”. The best place to stay in Kirkwood.This was my childhood home. Only 1/2 mile to downtown Historic Kirkwood with its many shops & restaurants,Farmers Market, Kirkwood Park & Pool & Train Depot. A couple of miles to Museum of Transport,Powder Valley Nature Center & Magic House Museum is a MUST if you have children.Home has steps to entry, railroad tracks up on the hill at the end of street. Close easy access to all major highways. Construction in area M-F

Aug 8 – 15

R2,983 ZAR per night

Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 497 reviews

301 Guesthouse SuperHost/Shop Discounts/Katy Trail

Our 301 Guest House is new and completely remodeled in 2018! It’s ideal for one or two people with beautiful furnishings, great queen bed, lots of amenities, full kitchen, with big back yard and patio to enjoy outdoors too! Cable and FAST WiFi! Enjoy light Breakfast! BEST location, Great events year round within walking distance, with being only about 2 blocks from S. Main St, where there are about 100 gift shops n restaurants! Katy Trail is so close, with Spring, Summer, Fall and Xmas events!

Dec 8 – 15

R2,529 ZAR per night

Guest favorite

Home in Augusta

4.99 out of 5 average rating, 221 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Nov 21 – 28

R3,307 ZAR per night

Guest favorite

Home in Granite City

4.98 out of 5 average rating, 127 reviews

Cozy 2-bedroom home minutes from ST. Louis, MO

Welcome to the Sheridan House. This cozy 2-bedroom home is located in a quiet neighborhood. It sets on a corner lot with a large back yard and a parkway across the street. Spend relaxing evenings on the patio, grilling your dinner. Or challenge your partner to a game of ping pong in the basement rec room. Centrally located, you can spend your days exploring attractions in Saint Louis, Mo, Alton and Edwardsville, IL. Just minutes from World Wide Technology Raceway, Busch Stadium, & the Arch.

Dec 19 – 26

R2,185 ZAR per night

Guest favorite

Home in Saint Charles

4.96 out of 5 average rating, 191 reviews

Sweet Escape Near Historic Main Street & MO River

Find a sweet escape in a cozy bungalow! Walk to Main Street in 15 minutes! This 4-bedroom house is the perfect location to explore St. Charles & St. Louis. Historic Main Street has shops, restaurants, & events on a cobblestone street. The semi-finished basement is a game-room with a pool table, ping-pong, foosball, & darts! There are board games & DVD’s as well. Outside, you have yard games & a fire pit! Comfortable beds with plush bedding & room-darkening curtains will ensure a restful night.

Dec 28 – Jan 4

R2,855 ZAR per night

Guest favorite

Home in O'Fallon

4.84 out of 5 average rating, 148 reviews

The Gathering Home 3bdrm 1 bth

This Home is in a great location for visiting family, and for corporate stays. This house has been renovated, has a fully equiped kitchen, laundry facility, comfortable beds, 2 Flat screen tv, WiFi, a fenced in yard, deck, lower level has a walk out basement to a patio. Central Heat and A/C., walking distance to Good News Brewery, Rendezvous wine Bar. , Banquet Center, Bowling Alley, Scotters Coffee, St. louis is 40 minutes, 1 minute from Hwy 70/Hwy K exit., 25 minutes to STL airport.

Jul 7 – 14

R2,598 ZAR per night

Guest favorite

Home in Saint Charles

4.95 out of 5 average rating, 119 reviews

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

New Carpet! Adorable turn of the century home is located in Midtown St. Charles Historic District and sleeps 7. You won’t want to miss this St. Charles Charmer! Updated, fully stocked kitchen, dining room with Keurig coffee bar, living room w/75" SmartTV and plenty of seating throughout, SmartTV in 2 Bedrooms, 2 full bath, washer & dryer, outdoor gazebo w/table & chairs. Street & driveway parking. Close to area attractions: Historic Main Street, Ameristar Casino, & Lindenwood University.

Mar 25 – Apr 1

R3,372 ZAR per night

Guest favorite

Home in Saint Charles

4.9 out of 5 average rating, 156 reviews

Tompkins Street Retreat

Relax in this 2 bedroom, 2 bath house with backyard patio and firepit with privacy fence. Walk to unique shopping and entertainment on Historic St. Charles Main Street. Augusta wineries and St Louis area attractions are a short drive away. Enjoy the comfortable living room with large TV, the fully equipped kitchen for special meals. Unwind after an active day with a meal under the pergola and drinks around the fire pit. The spacious main bedroom is perfect for a quiet restful night.

Sep 15 – 22

R2,705 ZAR per night

Guest favorite

Home in Saint Charles

4.99 out of 5 average rating, 159 reviews

Charming Bungalow in Historic St. Charles, MO

This charming bungalow is located in the heart of Historic St. Charles, Missouri. Just blocks from Historic Main Street where you can enjoy dining & shopping from a variety of local businesses, as well as Frontier Park & the Katy Trail which are perfect for a stroll or bike ride! The bungalow is steps away from Lindenwood University, a short drive to Streets of St. Charles & Ameristar Casino, a 15 minute drive to St. Louis Lambert Airport, and a 30 minute drive to downtown St. Louis!

Mar 26 – Apr 2

R5,724 ZAR per night

Guest favorite

Home in Ballwin

4.94 out of 5 average rating, 138 reviews

Entire lower level of our home w/Paris Theme

Our home is located in a quiet West St. Louis County neighborhood. The lower/walkout of this place is your home away from home. It has a private entrance from a walk around sidewalk to the backyard. You will have the entire lower level of our home. We live in the upstairs or first floor of this home. Our place is best suited for one couple, solo adventurers, business travelers, and one family (with kids). This space has been recently remodeled with a French Parisian theme!

Jul 22 – 29

R1,900 ZAR per night