Hotel vacation rentals in South San Francisco

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Top-rated hotel rentals in South San Francisco

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Hotel room in Sunnyvale

4.84 out of 5 average rating, 25 reviews

Bright Studio Suite King Bed with Kitchen

Centrally located in the Silicon Valley, enjoy our spacious suite with fully equipped kitchen. Enjoy FREE breakfast, FREE wireless internet and more. Across the street from Safeway Grocery, Starbucks, Jamba Juice, many specialty shops and an array restaurants. Nearby to Levi Stadium, Shoreline Amphitheater, California's Great America, Winchester Mystery House, Twin Creeks Sports Complex, Santa Clara University, Santa Clara Swim Club, Santa Clara Kaiser and the Santa Clara Convention Center.

Guest favorite

Hotel room in South Beach

4.79 out of 5 average rating, 47 reviews

SoMa 9 Residences Room 7 Shared Bath

SOMA (short for South of Market St) is top of the list for where to stay in San Francisco for the first time. SOMA 9 Residences is located in the Heart of SF SOMA District, were you'll find everything from shopping to fine dining, plus landmarks such as Yerba Buena, Moscone convention center, SF MOMA, and steps away to Giants Ballpark. The proximity to Market St. makes SOMA one of the most accessible areas of the city. There's buses and rail lines (called BART) on just about every block.

Superhost

Hotel room in Downtown / Union Square

4.8 out of 5 average rating, 61 reviews

Book-filled Writer’s Alcove in the lobby

Channeling the spirit of the Beat Generation, every room at Hotel Emblem is a creative retreat featuring a writing desk with an inspiration board. Enjoy plush pillowtop beds with Italian linens, a 55" HD TV, and unique touches like a meditation bowl, typewriter, and coloring books. Thoughtful amenities include in-room coffee and tea, ROIL bath products, and high-speed internet. With pet-friendly options and hotel bikes, your San Francisco stay is both inspiring and comfortable.

Superhost

Hotel room in Nob Hill

4.59 out of 5 average rating, 32 reviews

Art-centric stay with views from atop Nob Hill

Power down and recharge in our stylish, minimalist accommodations—an ideal retreat for modern mavericks and mavens seeking a break from the city’s energy. Enjoy clean lines, custom-designed furniture, and thoughtfully simple design for ultimate comfort. Our compact, interior-facing rooms span 205–220 square feet and feature a Queen or King bed. Each space is efficiently equipped with a 49” HD television, HDMI and USB ports, USB outlets, and a mini-fridge for your convenience.

Guest favorite

Hotel room in Millbrae

4.87 out of 5 average rating, 47 reviews

Hotel Room | Free Breakfast. Bay Area.

If you plan to explore the Bay Area, The Millwood Inn & Suites is a great jumping-off point. This quaint hotel is located in Millbrae, California, only minutes from Bay Area attractions such as the Golden Gate Bridge. It is also only a six-minute drive from San Francisco International Airport, perfect for those flying in! Be welcomed into a world of comfort and convenience after a long day of exploring California's best. ✔ Free breakfast ✔ Free parking ✔ Fitness center

Superhost

Hotel room in Downtown / Union Square

4.88 out of 5 average rating, 8 reviews

Fun Respite | Happy Hour. Game Room. Pet Friendly.

Axiom Hotel, a 4-star establishment in San Francisco's city center, is an ideal accommodation for those looking for a fun hotel to stay in during their trip to SF. It features a fitness center and a game room. Guests can also venture out to see prime attractions nearby, like Moscone Center and the Ferry Building. ✔ Fitness center ✔ Robot-delivered room service ✔ Pet-friendly ✔ Arcade games ✔ Cafe on-site ✔ Breakfast, lunch, dinner, boba and a full bar

Resort in Lower Nob Hill

4.9 out of 5 average rating, 10 reviews

Urban Retreat: 1BR Suite at Wyndham Canterbury

Welcome to Wyndham Canterbury Resort, a celebrated destination that seamlessly blends history with contemporary style. Nestled in the heart of San Francisco, this iconic resort has been thoughtfully renovated to offer a captivating and comfortable stay. Unwind in the inviting living area and take in the surroundings of your home away from home. The suite features a partial kitchenette, perfect for preparing light meals and snacks at your convenience.

Superhost

Hotel room in Pacific Heights

4.8 out of 5 average rating, 49 reviews

Monroe Studio 303

The Monroe Residence Club is a residential hotel located centrally in the heart of San Francisco with public transportation at our doorstep and local shops and businesses nearby. It is conveniently located just a block from Whole Foods, blocks from a the iconic Lafayette Park, within walking distance of several hospitals and more! The Monroe offers 24-hour front desk security, breakfast and dinner on-site, as well as common areas for congregating.

Guest favorite

Hotel room in Mountain View

4.9 out of 5 average rating, 744 reviews

King Bed at Shashi Hotel in Mountain View

Experience our King room type at Shashi Hotel Mountain View, an Urban Resort. Conveniently, located in the heart of the Silicon Valley - walking distance to Shoreline Amphitheatre. Taste incredible cocktails and delicious bites at our Emerald Hour Bar designed by our Michelin-rated Chef. Enjoy complimentary amenities including our outdoor pool, fitness center, sauna and steam rooms. New for 2025 - daily wine tasting, yoga, zumba, and live music.

Guest favorite

Casa particular in Panhandle

4.95 out of 5 average rating, 119 reviews

Boutique large studio in NoPa San Francisco

Self-contained large studio in San Francisco with kitchenette. Located in San Francisco's NoPa area which provides some of the best restaurants and bars in the city as well as close access to the outside spaces of the Panhandle and Golden Gate Park. The studio is located on a quiet street which is a 5 minute walk from the NoPa restaurants and Bi-Rite on Divisadero, 7 mins walk from Alamo Square and 15 mins walk from Golden Gate Park

Guest favorite

Hotel room in Nob Hill

5 out of 5 average rating, 7 reviews

San Francisco Suites Studio lll on Nob Hill

Unwind in this quiet and cozy parlor suite, designed for ultimate relaxation. Tucked away from street noise, you'll enjoy a peaceful atmosphere perfect for a restful getaway. The open and airy floor plan features a comfortable space, and you can indulge in the whirlpool Jacuzzi bathtub/shower combination. Prepare your favorite meals in the full kitchen, making your stay even more convenient and enjoyable.

Guest favorite

Hotel room in Tenderloin

4.9 out of 5 average rating, 42 reviews

Sophisticated & Stylish Stay In Union Square | Bar

The Marker brings sophistication and style to San Francisco like no other. Set in one of the most vibrant and captivating cities in the world, the Beaux-arts style hotel invites you to feel inspired and right at home. Just steps from Union Square, welcome to The Marker, where modern elegance effortlessly blends to classic Bay Area charm. Winner of the Conde Nast Traveler Readers Choice Awards 2019-2022.