Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Condo in Chame

4.96 out of 5 average rating, 137 reviews

Exclusive Beachfront apartment 1Hour from Pma City

ESPECTACULAR apartamento de lujo FULL EQUIPADO con 3 recamaras (todas con vista directa al mar), 2 baños completos y medio baño de visita; cuarto y baño de servicio. Finos acabados, cocina 100% de acero inoxidable y aires acondicionados en todo el apartamento de alta eficiencia. Condominio con concepto "Hotel Style Living"; Restaurante y Bar para las noches (de Jueves a Domingo), snack bar en el area de la piscina y un Tiki Bar en la playa, ademas de cancha de Volleyball , Tenis, basketball.

Aug 5 – 12

R2,859 ZAR per night

Guest favorite

Condo in Nueva Gorgona

5.0 out of 5 average rating, 16 reviews

20th Flr Beachfront Nueva Gorgona, Panamá 2/3 unit

Come and unwind in this exclusive and serene high-rise beachfront retreat also known as "My Happy Place". This is a 2 bedroom, 3 bath unit. You'll find yourself just 80 minutes away from Panama City, a location offering breathtaking sunrise and sunset views, with the beach just steps away. Indulge in modern décor that adds a touch of sophistication to your home away from home. Enjoy the soothing sounds of the waves. Immerse yourself in the calming ambiance of this remarkable beachfront condo.

Aug 9 – 16

R2,527 ZAR per night

Guest favorite

Home in Costa Esmeralda

4.96 out of 5 average rating, 106 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sand! Come relax with the whole family at this piece of paradise. Majestic Sand is located in a private beach community in Costa Esmeralda, San Carlos District, Panama. It is located a few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, Santa Clara and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool with multiple hammocks with views of amazing palm trees.

Oct 11 – 18

R3,421 ZAR per night

Guest favorite

Villa in Chame

4.83 out of 5 average rating, 127 reviews

Surf Relax Play Pacific Ocean View Villa

White sand, surf-able waves, or just a comfortable chill vibe to enjoy the tropical weather of Panama. Playa Caracol is about an hour and 10 minutes drive from the city. This spacious, 2 bedroom, 2 bath villa with it's Pacific Ocean front location is the perfect place for you to enjoy an unforgettable family vacation. Walk out to the beach just steps from the villa, swim in the pool next to this villa or enjoy the resort pools and amenities. Or hike the nearby mountains with a local guide.

Sep 18 – 25

R2,245 ZAR per night

Superhost

Cabin in Panamá Oeste

4.8 out of 5 average rating, 225 reviews

Cabaña Mirador by Casa Amaya

Casa Amaya es un complejo de cabañas ubicado a una hora de la ciudad capital, en Chicá de Chame, con temperaturas agradables entre 18 y 24 grados, donde podrás contactarte con la naturaleza y relajarte con tu pareja, amigos o familia. Otras cabañas: https://www.airbnb.com/h/lospinosbycasaamaya https://www.airbnb.com/h/buenavistabycasaamaya https://www.airbnb.com/h/panoramabycasaamaya https://www.airbnb.com/h/horizontebycasaamaya Contamos con generador eléctrico en caso de apagón.

Nov 12 – 19

R1,226 ZAR per night

Guest favorite

Apartment in Nueva Gorgona

4.86 out of 5 average rating, 144 reviews

Condo Nueva Gorgona Beach Front for 4 peoples

Condo Gorgona Beach Front is located on the 6th floor of Royal Palm, facing the beach with ocean views from the balcony and the room. It has 3 swimming pools, direct access to the beach, restaurant, address and more. This cozy apartment for a family or friends of 4 is an excellent economic option to enjoy luxurious amenities within the building. We treat each property like a hotel, so we invite you to enjoy this cozy apartment as you deserve. Book now!

Sep 19 – 26

R1,415 ZAR per night

Guest favorite

Home in El Valle de Antón

4.93 out of 5 average rating, 118 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Jul 16 – 23

R2,149 ZAR per night

Guest favorite

Condo in Nueva Gorgona

4.91 out of 5 average rating, 54 reviews

Wake up to a Stunning Beach View

Do you want to wake up to a beach view? This is the place for you. Hear the waves from your bedroom. Sit in your living room watching the waves come in. This condo also comes with a restaurant downstairs by the pools. Gymnasium, Spa, Sports Courts, Play Area for Kids and a BBQ area for outdoor cookouts. Full kitchen and laundry inside the condo. 2 bedrooms master has a queen bed and the guest room has 2 twin beds.

Aug 2 – 9

R1,668 ZAR per night

Guest favorite

Cabin in Panamá Oeste

4.88 out of 5 average rating, 121 reviews

Altos del María Cabaña La Loma de Styria

Relájate con toda la familia en este tranquilo lugar para quedarse. Es un lugar fantástico, fresco y agradable donde puedes hacer muchas actividades ecoturísticas, la mejor opción si deseas tener una de las mejores vistas que puedas imaginar. Ideal para parejas también. Contamos con 2 habitaciones 2do piso y 2 baños. Múltiples lugares para tomar bellísimas fotografías

Oct 2 – 9

R2,300 ZAR per night

Guest favorite

Tiny home in Altos del Maria

4.89 out of 5 average rating, 46 reviews

Casa Arcón

This earth-sheltered studio home offers a unique and romantic escape in the mountain of Altos del Maria. Cozy space surrounded by a lush green environment, ideal for those seeking a peaceful getaway, or an affordable stay to explore the gated community's amenities. This bunker home provides an inviting haven to unwind and disconnect from the hustle of city life.

May 28 – Jun 4

R1,162 ZAR per night

Guest favorite

Guest suite in Panamá Oeste

4.85 out of 5 average rating, 81 reviews

Casa Buena Vista

The house is newly built within walking distance to the lookout in the Altos De Campana National Park only 45 minutes from Panama City. With absolutely stunning views it sleeps 4 to make your stay a relaxing, tranquil experience. Bring your own cooler, cook for yourself in a full complete kitchen if you like and enjoy your drinks by the pool.

Aug 16 – 23

R1,269 ZAR per night

Guest favorite

Condo in Nueva Gorgona

4.94 out of 5 average rating, 126 reviews

Fabuloso Apto de playa-Ph Royal Palm-Gorgona

PRIMERA LINEA AL MAR CON BAJADA DIRECTA A LA PLAYA DESDE LAS PISCINAS DEL PH . Fabuloso APTO DE PLAYA, Beach Front Unit, cómodo, único y para relajarte en Familia, cuenta con 4 increíbles piscinas, jacuzzi, sauna, canchas deportivas, juegos de mesa y acceso a la playa y servicio de Restaurante, venir es no querer irte nunca

Dec 9 – 16

R2,934 ZAR per night