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Houses for rent in Santee

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Top-rated houses for rent in Santee

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A bright corner space features a window with a view of outdoor greenery. A wooden table is set for two, surrounded by black metal chairs. A cozy blue armchair and a side table complement the warm tones of the hardwood flooring and a colorful area rug.

Home in El Cajon

5 out of 5 average rating, 31 reviews

Charming Cozy Studio Centrally Located

Welcome to our dreamy, San Diego-inspired private petite suite. The studio has its own entrance and perfect for solo travelers or couples. Nestled in a quiet and secure neighborhood, it’s centrally located, near shops, restaurants, and with convenient access to all major attractions. Enjoy complimentary coffee, snacks, and tea, get inspired by our quote wall, relax with a book in the floral tiny patio. This space offers a perfect blend of comfort and style, with all you need for a relaxing stay!

An outdoor area features a clear saltwater pool surrounded by elegant lounge chairs. A shaded umbrella stands nearby, and the landscape includes rolling hills and a distant view of the mountains, providing a serene backdrop for relaxation.

Home in El Cajon

4.98 out of 5 average rating, 120 reviews

Fletcher Hills luxury, Sunset View, 4 BR, Pool/Spa

A luxury, house with private entrance and saltwater pool/jacuzzi Located in Fletcher Hills,Ca house located on a hill with the views of mountains and San Diego city. Enjoy this fully and luxuriously furnished 4 bedroom, 2 full bath, pool/ Jacuzzi , w/ color changing LED lights, Get full access to your own kitchen with all the amenities. Wifi access. Smart TV access to Netflix.This house is good for couples, business travelers, and families with kids! It's cozy, comfy, and feel right at home.

The interior of the studio showcases a spacious layout, featuring a king size bed adorned with yellow and white pillows. A dark gray sofa complements the decor, facing a coffee table with a plant. Large glass doors provide a view of the garden and outdoor seating.

Home in La Mesa

4.9 out of 5 average rating, 245 reviews

Hidden King Suite with Garden, Parking - 4 Guest

Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Top guest favorite

A spacious studio features a comfortable queen bed topped with a patterned blanket. Natural light filters in through a nearby window, illuminating the room's neutral tones. A piece of art depicting a tree-lined path hangs above the bed, enhancing the room's calming ambiance.

Home in Lakeside

4.99 out of 5 average rating, 100 reviews

Terra Mesa - Charming Retreat

Welcome to TerraMesa! This charming studio boasts a thoughtfully designed space, blending modern comfort with a touch of rustic elegance. With a fully equipped kitchenette, a plush queen bed, and a stylish sitting area, it’s perfect for couples seeking a romantic getaway or solo travelers exploring the San Diego area. Sip a cup of coffee or glass of wine in your private little patio. Centrally located in scenic Lakeside, you’ll have easy access to downtown, beaches or our local mountain towns.

Top guest favorite

An outdoor patio area features a round table with four chairs, all adorned with colorful cushions. A large red umbrella provides shade, and a decorative rug adds vibrancy to the stone surface. Surrounding greenery and blooming plants create a serene environment.

Home in Rolando

4.98 out of 5 average rating, 310 reviews

Travel Writer's Pad

Hello, Bonjour, Hola, Ciao, Ni Hao! For the past two decades my career as a travel journalist has taken me around the globe. I’ve stayed at thousands of accommodations, where I learned personal touches create a comfortable home away from home. Certain places I visited offered extra special amenities, such as Green tea at a Japanese Ryokan & chardonnay infused bath salts at a Mexican posada. These kinds of touches are in the home. I welcome you, but no parties or events at the house. Thanks!

An open-concept living area is highlighted by high ceilings and large windows, offering natural light. A modern kitchen features wood cabinets and a white island, while a dining table with turquoise chairs accommodates several guests. A cozy seating area is visible in the background.

4.97 out of 5 average rating, 829 reviews

The Glass House - A Nature Retreat

Enjoy a unique retreat; 180 degrees of views from inside the home. Nestled at the end of a private road, our place is nearby great hiking and countryside wineries. The Glass House provides a magical space and nature retreat where individuals, couples, families and friends can gather together to re-connect with nature, each other, and themselves. The breathtaking mountain top views, the huge deck, hot tub, fireplace, and the open concept living space is unbeatable for the perfect getaway.

The kitchen area features modern black cabinetry and stainless steel appliances, including a microwave and compact refrigerator. A smart TV is mounted on the wall, complementing the wooden counter workspace equipped with essential cooking utensils. A dining table with two chairs is positioned nearby.

Home in La Mesa

4.86 out of 5 average rating, 219 reviews

Newer "Manor Studio"

Centrally located in San Diego County this newer studio style unit has a private entrance, private patio area and street parking. Furnished with a queen size bed, love seat, full bathroom and kitchen area. One large drawer to accommodate personal items, and a wall rack to hang clothing. There is a smart TV with WiFi streaming capabilities and lots of USB plugs to charge your devices. On street parking in front of unit (no parking in driveway). No Pets allowed. No Hair Dying allowed.

Top guest favorite

A view into a modern living space reveals a sleek kitchen with bar seating and a spacious dining area. Natural light floods the room through large glass doors, showcasing lush greenery outside. A cozy area is completed with a colorful rug beneath and a inviting seating arrangement.

Home in La Mesa

4.94 out of 5 average rating, 218 reviews

Cottage in the Garden! New! Modern!

COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Top guest favorite

A colorful studio space features turquoise walls and a ceiling fan. A comfortable sofa with decorative pillows is paired with a coffee table. A bed with a floral-patterned comforter sits against a window, while a TV and white refrigerator complete the modern setup.

Home in La Mesa

4.99 out of 5 average rating, 244 reviews

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

A light-filled living space features a white sofa adorned with colorful cushions and a patterned throw. A framed image of a cow's head hangs on a yellow and white accent wall. A small table sits nearby with a potted plant, complementing the minimalist design.

Home in Lemon Grove

4.93 out of 5 average rating, 196 reviews

NEW- King Bed: Very clean, Quiet, A/C, parking

Enjoy a stylish experience at this centrally-located place. Kick back and relax in this calm, stylish suburban feel home near major local attractions. 15 minutes from downtown 15 minutes from the party scene 17 minutes from San Diego zoo 18 minutes from beaches 20 minutes from sea world 20 mins from Coronado CA 23 mins from the Mexico port of entry 40 MIN TO SAFARI ZOO 40 minutes from Legoland 1 hr to the desert 1.5 hrs to LA Near everything yet far away from city chaos

A vibrant karaoke room is showcased, featuring a plush pink sofa and stylish ottomans on a patterned rug. Neon lights accentuate the space, complemented by a wall-mounted television and ambient lighting from circular fixtures overhead. Dark curtains frame the windows, adding privacy to the area.

Home in El Cajon

4.93 out of 5 average rating, 116 reviews

Sunshine Villa: Karaoke, Pool, Spa & Arcades

SEND US A MESSAGE FOR SPECIAL OFFER! Imagine booking the most memorable experience with your party! You can kick back in a safe family oriented experience! Check in contactless & enjoy! Property Highlights: Pool Spa Karaoke Room 10 beds Ping Pong BBQ/GRILL Outdoor Games With the house comes parking up to 7 cars. You'll find 2 bathrooms, and an alluring kitchen. The entire house is 30 mins from the beach, airport and zoo!

Top guest favorite

The studio features a spacious bed adorned with a plush white quilt. A decorative basket with a bottle and glass rests on the bed. A cozy love seat is positioned nearby, complemented by soft grey curtains that frame the window, allowing natural light to illuminate the room.

Home in El Cajon

4.97 out of 5 average rating, 136 reviews

Suite Charles Way: A Cozy Fletcher Hills Studio

This newly remodeled spacious studio retreat features a private courtyard with barbecue, kitchenette, a brand-new California King bed, and a reclining love seat with charging ports. Enjoy a relaxed cabana vibe, a charming neighborhood and treetop views with easy access to all your favorite San Diego destinations. Within minutes from Grossmont Sharp Hospital, Grossmont Center, the trolley and Grossmont College.

Vacation rentals for every style

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Stylish accommodations and amenities

Popular amenities for Santee vacation rentals

Laptop-friendly workspace

Vacation rentals in Santee

Top guest favorite

A modern multi-level building showcases white stucco exteriors and various balconies. Lush greenery and palm trees surround the property, providing a vibrant contrast against the bright architecture. Neighboring homes offer glimpses of a charming residential area, with the distant ocean visible beyond the rooftops.

Guesthouse in Mission Hills

5 out of 5 average rating, 184 reviews

Santorini-Inspired Cottage w/ Hot Tub + Views

AngelRating, 5 stars2 weeks ago

Alta Colina was by far the best Airbnb experience me and my fiancé have ever stayed at. From the stunning views up in the hills to the our amazing host Erica who went above and beyond to make sure our stay was extra special. I really couldn’t recommend this place enough for anyone looking to stay in the area. The general location is also perfect as it’s very centralized to most of the popular neighborhoods in San Diego never requiring more than a 20 min drive for us to get where we wanted to be. Of course the place itself was gorgeous on top of everything, the listed photos matches the area you will be staying in perfectly. Alta Colina will definitely be a place we will have to return to whenever we visit the area again and the memories made there will be something that we’ll surely never forget.

Two friendly Nigerian dwarf goats are seen side by side, one with light brown fur and striking blue eyes, while the other has black fur and distinctive white markings on its face. The background includes blurred greenery, suggesting a natural setting.

Guesthouse in Escondido

4.91 out of 5 average rating, 757 reviews

Hilltop cabin retreat with lake & mountain views

SavannahRating, 5 stars6 days ago

This place was an AMAZING stay! Such a great place to chill and hangout by the pool and enjoy the property. The only thing missing was some kind of air conditioning in the cabin, but really only necessary for the hot months. Otherwise everything was perfect! Will be coming back for sure.

Top guest favorite

An inviting pathway leads through a landscaped garden featuring a mix of colorful plants, boulders, and decorative stones. Wood stairs provide access, while gentle curves of concrete walkways connect to the surrounding natural scenery.

Guesthouse in El Cajon

4.99 out of 5 average rating, 187 reviews

Modern mountain guest house. Incredible views

HollyRating, 5 starstoday

This was a great house! The kitchen is stocked with the basics plus plenty of coffee, creamer, etc. and a basket of snacks! Water dispenser is also great. Loved everything and would absolutely stay here again and highly recommend it! Thank you Bonnie!

Top guest favorite

A view of the backyard captures a tranquil pool surrounded by lush greenery. A shaded BBQ area stands nearby under a thatched roof, with seating options visible. Sunlight filters through the trees, creating a serene atmosphere in this private outdoor space.

Guesthouse in La Mesa

4.99 out of 5 average rating, 114 reviews

Private 1 BR Paradise retreat

AnnaRating, 5 starstoday

we had a wonderful, relaxing time. we where only there for 2 days for our Grandson's graduation. it was hard to leave such a beautiful home and grounds. we will definitely come back and stay when we can be there most of the time.the pool was beautiful. the house was sparkling clean. Jeanne and John were most welcoming. very nice to talk to.

Guest suite in La Mesa

4.85 out of 5 average rating, 113 reviews

Gorgeous San Diego 1 Bed Studio with everything!

Jessica Rating, 5 stars1 week ago

Cindy was very responsive, and the location was cute and cozy. Loved the place, and would recommend to others.

Top guest favorite

The kitchenette features modern appliances, including a sleek white toaster and a stainless steel coffee maker with a water dispenser. The countertop includes a textured stone backsplash that adds a contemporary touch to the space.

Guest suite in La Mesa

4.99 out of 5 average rating, 106 reviews

Emerald Suite Spa Experience with Sauna & Desk

JaredRating, 5 stars1 week ago

Awesome stay! The place was super peaceful And clean. The host was very nice and accommodated a last minute request. Will be back again!! 5/5 stars :)))

A serene outdoor space is depicted, featuring a canopy of blue fabric and warm white string lights illuminating the area. Lush greenery, including various plants, can be seen, alongside a well-maintained garden backdrop. The peaceful evening sky casts a soft glow over the setting.

Guest suite in La Mesa

4.88 out of 5 average rating, 156 reviews

La Mesa Granny Flat

KaitlynRating, 5 stars3 weeks ago

Mike and rubys home was very cozy and comfortable! It was very clean and the decor made it super cute! We enjoyed our stay during Mother’s Day weekend and would love to come again!

Top guest favorite

A clean and modern shower features two white shelving units displaying body wash, shampoo, and conditioner in simple, minimalist bottles. The white tiled walls provide a fresh backdrop, while a polished metal shower faucet adds a touch of elegance.

Tiny home in La Mesa

4.99 out of 5 average rating, 153 reviews

Townhouse - Private Yard, La Mesa Village

SergioRating, 5 stars2 weeks ago

Visited Casita de Pueblo during my family’s Southern California vacation. The space felt very private and welcoming. Our host, Amy was very helpful and thoughtful. We highly recommend staying here!

Other great vacation rentals in Santee

A sparkling pool is surrounded by lush greenery and colorful flower beds, providing a serene outdoor space. The guesthouse is visible in the background, with access to the patio area and the inviting blue water reflecting the clear sky.

Guesthouse in El Cajon

4.87 out of 5 average rating, 115 reviews

Private guesthouse for 1-2 in quiet Fletcher Hills

SherryRating, 5 stars9 months ago

The place was ideal for our needs and close to everything we planned with family and friends. Beautiful setting, felt very secure in this neighborhood. Pool and but was peaceful and relaxing after a full day. Loved their little doggy too!

A modern flat-screen TV is mounted on the light gray wall, providing entertainment options. Below, a small black table is paired with two sleek, black chairs. The flooring is tiled in a light gray tone, enhancing the clean design of the space.

Guesthouse in Lake Murray

4.93 out of 5 average rating, 238 reviews

Fig Tree Bungalow

MahmoudRating, 5 stars2 weeks ago

Great stay. As described

Top guest favorite

The studio features a spacious living area with wooden beams overhead, blending natural tones and textures. A cozy sofa sits on a patterned rug, with a coffee table displaying materials. A kitchen area with a breakfast bar and stools is visible, along with a queen bed in the corner.

Guesthouse in La Mesa

4.99 out of 5 average rating, 279 reviews

Spacious, private Mt. Helix country style studio

RhondaRating, 5 stars1 month ago

Absolutely worth it. Beautiful place. Cozy with gorgeous gardens. Also a nice welcome touch of bowl of fruits, chocolates and plenty to drink. Loved it.

Top guest favorite

A serene outdoor space is illuminated by soft lighting, featuring stone pathways and gentle landscaping. A fence encloses the area, with tall trees and distant views of city lights enhancing the nighttime ambiance. A small table is present among the evening setting.

Guest suite in El Cajon

4.96 out of 5 average rating, 224 reviews

NEW! Valley View Garden Suite

JahairaRating, 5 stars1 week ago

We enjoyed the stay at Kim’s guest house. She was very kind and responsive and the space was clean! Would definitely recommend staying here.

Top guest favorite

Guesthouse in La Mesa

4.97 out of 5 average rating, 203 reviews

Da Hui Hut - La Mesa’s best view and spa

LuciaRating, 5 starstoday

What a Tiki treat! The views are beyond majestic ✨🌿✨ Sweet hosts ✨ You will be glad you experienced this ✨

Top guest favorite

A serene landscape showcases a vibrant sunset with soft pink and orange hues above a blanket of fog, which covers the rolling hills and mountains in the distance. Lush greenery can be seen in the foreground, creating a tranquil setting.

Guesthouse in El Cajon

4.98 out of 5 average rating, 220 reviews

Fletcher Hills - modern 1 BR.Easy, no step access.

JeffRating, 5 stars1 week ago

Fantastic views. Very comfortable and inviting. The outside lounging area was excellent. Everything we wanted. This area of San Diego Metro is very beautiful. This looks to be a very safe, quiet and friendly neighborhood. It is centrally located to all of the main attractions.

Guest suite in Lakeside

4.94 out of 5 average rating, 103 reviews

Noonan's Nest

CynthiaRating, 5 stars2 weeks ago

Noonan's Nest is a spacious one-bedroom suite. We had plenty of room and didn't feel cramped compared to other locations where we have stayed. Our hosts were very friendly and readily shared information about area restaurants and other stores. It was conveniently located near our family, so we will definitely consider staying again on our next trip to the San Diego area.

Top guest favorite

A private patio area features a metal bench overlooking a landscaped yard with terraced garden beds. A path, lined with steps, leads up the hill. Natural greenery surrounds the space, providing a tranquil atmosphere. A large container is visible for waste disposal.

Apartment in La Mesa

4.98 out of 5 average rating, 154 reviews

Lovely Hideaway Studio by Village-Private Patio

MeganRating, 5 stars2 months ago

This is hands down one of the best stays my husband and I have ever had! Not only was the place super easy to find, but it was well stocked, clean and comfortable. The host, Connie, was extremely kind and flexible with us when our check in was late. She made us feel right at home and the value of the stay far exceeds the price. I highly recommend their granny flat in La Mesa and hope I can come back again very soon!!

Quick stats about vacation rentals in Santee

Total rentals
100 properties
Total number of reviews
2.8K reviews
Family-friendly rentals
40 properties are a good fit for families
Pet-friendly rentals
20 properties allow pets
Rentals with a pool
40 properties have a pool
Rentals with dedicated workspaces
40 properties have a dedicated workspace

Frequently Asked Questions

Are there house rentals with a dedicated workspace in Santee?
Yes! Work meets play with ease at over 20 house rentals in Santee featuring dedicated workspaces. Stay connected and productive in your home away from home.
How much does it cost to stay in apartment rentals in Santee?
Experience the best of Santee with our apartment rentals, starting at about $30 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there Santee house rentals on Airbnb with pools?
Yes! Dive into the perfect getaway at one of over 20 house rentals with pools in Santee, available on Airbnb. Make a splash and soak up the sun in style!
Are there pet-friendly house rentals in Santee?
Four-legged friends are welcome in Santee. Choose from more than 10 house rentals for guests traveling with pets.
Do apartment rentals in Santee have wifi?
Absolutely! We offer over 10 apartment rentals with wifi in Santee. Enjoy a tailored experience with all the comforts you desire.
Are there family-friendly house rentals in Santee?
Santee has more than 30 family-friendly house rentals. Amenities on the property may include high chairs, travel cribs, or strollers.

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