Vacation rentals in Lyon

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Top-rated vacation rentals in Lyon

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Guest favorite

A cozy corner seating area features a bright blue upholstered couch with decorative pillows. A low, circular wooden table is positioned centrally. A green door with a unique design adds character to the wall, while framed artwork and photographs adorn the surrounding space.

Apartment in Clarksdale

4.93 out of 5 average rating, 178 reviews

The Squeeze Box-"get your Blues on"

LOCATION-LOCATION-LOCATION The Squeeze Box is a spacious, airy 425 sq. ft. private vacation apartment, located in the heart of Historic Downtown Clarksdale, Mississippi. The newly constructed apartment is located on the ground floor of the former Clarksdale Telegraph Building (Circa 1897) @ the corner of Second & Delta in the Historic Blues District. Located across the street from the Hambone Art Gallery, and the “Rock & Blues Museum”, this is the best location in town. Gift shops around the corner. Restaurants including The Stone Pony, Yazoo Pass, Levon's Bar and Grill, and Grandma's House of Pancakes are literally all within 300 feet of our front door. CatHead Blues, Lambfish Gallery, and Hambone Gallery are all on our block. The Delta Blues Museum is a short walk, and Ground Zero Blues Club, New Roxy and Red’s Lounge are an easy 5-minute stroll. The Squeeze Box is the best location in Clarksdale for walkable access to restaurants, music venues, museums,bars, clubs,art galleries,shopping on Delta,convenience store,and the wine & spirits store. No need to drive once you check in.....park your car, and party to your heart's content. And The Squeeze Box is located on the ground floor, so there are no stairways to climb or drag your bags up. And we have a covered veranda out front with seating for six,so you can enjoy the fresh air, while enjoying a nice beverage. Although there is no smoking allowed in the apartment, the veranda is just outside your door. Available by the night,weekends, and weekly. Inquire about longer stays.

Guest favorite

The exterior of the home features a vibrant yellow front door, flanked by decorative plants. The brick facade and large windows provide a welcoming entrance. A well-maintained lawn surrounds the front, enhancing the inviting appearance of the property.

Home in Clarksdale

5 out of 5 average rating, 29 reviews

Delta Dream Retreat (Entire Home)

Relax with the whole family at this peaceful place to stay. we have put our heart and soul into renovating this entire home with all new appliances , bedding, furniture, mattresses, etc. It Is very modern and comfortable for families. It incl wi-fi, usb and multi movie channels every room, games, coffee, water, tea, and complimentary snacks. Only one camera[ring door bell] at the front door. Great neighbors and less than 2m from downtown Blues venues, Historical Crossroads, & eateries.

Superhost

A cozy living area features two light-colored sofas opposite each other, adorned with decorative pillows. An intricate area rug covers the floor, complementing the rustic wooden walls and high ceiling. A room divider is positioned in the background, dividing the space from the bedroom. Natural light filters through the nearby windows.

Cottage in Clarksdale

4.91 out of 5 average rating, 316 reviews

Sunflower Cottage on the River

Only a mile from historic home of the blues, Clarksdale in a gated community. The cottage sits on the banks of the Sunflower River with beautiful views of rustic woods. Out your window you might see deer, fox & other wildlife. Take a walk along the riverbank. You’ll enjoy relaxing in the comfy beds, ,enjoy privacy, the piano , & closeness to all the blues music venues. It has two fire pits, an outside grill & full kitchen. Great for couples, adventurers, business travelers , musicians ,

Guest favorite

A charming blue cottage features a gabled roof and a white front door framed by two light fixtures. Two vintage chairs are positioned on the grassy area in front, surrounded by mature trees that provide some shade.

Cottage in Clarksdale

4.82 out of 5 average rating, 166 reviews

The Gallery at Chateau Debris

Welcome to The Gallery! This one-bedroom cottage sits behind the main house. It has recently been renovated, but is decorated with vintage furnishings for personality. The cottage is equipped with a full kitchen, bedroom, bathroom, washer and dryer, & Roku TV. Your stay will be unique, as the decor has been selected from my collector's lair, and the best part is - it's all for sale! The Gallery is a live-in collectibles showroom so, contrary to the saying - you CAN take it with you!

Top guest favorite

A living area is presented with a modern aesthetic, featuring a soft blue sofa and a small coffee table made of wood. An elegant chandelier hangs from the ceiling, while a TV is mounted on the wall, adding to the entertainment options.

Home in Mound Bayou

5 out of 5 average rating, 18 reviews

Cozy 4BR home with glass porch!

Welcome to this charming 4-bedroom home, perfect for families or groups seeking a relaxing getaway. With 1 full bathroom and 1 half bath, this spacious retreat offers comfort and convenience. The highlight is the beautiful glass-enclosed porch, ideal for enjoying meals, sipping drinks, or unwinding in a peaceful setting. Inside, you’ll find a cozy living area, a fully equipped kitchen, and stylish bedrooms designed for comfort. Book your stay today and create unforgettable memories!

Guest favorite

The living area features two comfortable sofas with coordinating patterned pillows. A glass coffee table sits in between, and a dining table with two chairs is positioned nearby. Natural light streams through the large windows dressed with sheer curtains.

Loft in Clarksdale

4.86 out of 5 average rating, 22 reviews

Sunflower Lofts C

Welcome to The Sunflower Lofts! These modern, fully furnished apartment style accommodations are located in the heart of downtown Clarksdale. With a coffee shop just a few doors down and all the best restaurants & music venues within walking distance, you won't even need to get in the car until you leave! We accept long and short-term guests, so stay with us for one night or a few weeks! No pets. No smoking. Quiet hours begin at 10:00 pm. We do not accept local reservations.

Superhost

A living area features dark leather recliners arranged around a small coffee table. The room displays wooden accents and a staircase leading to the upper level. A hallway with artwork and natural light creates a welcoming atmosphere.

Home in Lyon

4.83 out of 5 average rating, 6 reviews

Safe Clarksdale Stay/Secluded 2600 sf barndominium

Take it easy at this unique and tranquil getaway. Enjoy beautiful sunsets and pastoral scenery while you relax in the spacious barn house. Right in the middle of Mississippi Delta farm land. Traveling for work, tourist, hunters everyone has enjoyed staying at the "Barn House." Safest place in the area to stay. Plenty of room for boats, trailers and vehicles. Stalls for horses also available.

Guest favorite

The brick exterior of Blues Hound Flat is characterized by large glass block windows and a centrally positioned red door. Horizontal blinds cover the windows, providing a sense of privacy while allowing light to filter through. A small air conditioning unit is visible above the door.

Loft in Clarksdale

4.93 out of 5 average rating, 437 reviews

Blues Hound Flat

Blues Hound Flat sits quietly across from the historic Greyhound bus station in the center of downtown Clarksdale. Step outside, and you're in the heart of the Delta Blues, surrounded by local eateries, shops, bars, and music venues! The air itself is heavy with the traditions of the Delta. This loft-style flat features all the basic amenities one could want and solitude when needed.

Guest favorite

The living area features exposed brick walls and large windows, providing natural light. A cozy couch is complemented by two side tables and lamps on either side. A decorative coffee table enhances the inviting atmosphere of the space.

Apartment in Clarksdale

4.88 out of 5 average rating, 26 reviews

High Cotton Condo Unit D

High Cotton Condo Unit D is centrally located in heart of downtown Clarksdale with 2 bedroom, 2 baths, and a foldout couch in the living room. This unit is updated and fresh with a large living room, a modern kitchen, and great retractable windows that look out onto Delta Avenue below! Condo D has all the modern luxuries you need to make your trip to Clarksdale complete!

Guest favorite

The exterior of a single-story house is highlighted by a well-maintained lawn, framed by trees. Light-colored siding and brown shutters complement the entrance, which features a white door and a welcoming open porch area.

Home in Marvell

4.94 out of 5 average rating, 16 reviews

Tranquil home away from home

Relax with the whole family at this peaceful place to stay. The Parsonage accommodates everyone! 3 bedroom, 2 bath home in the center of town immersing you in a little slice of home. The house has two separate living areas, an eat-in bar, dining room and a fenced in backyard and storage building available if needed during your visit or hunting trips.

Guest favorite

A light blue bungalow with multiple sections is set among lush greenery. The home features a raised porch with steps leading up and a railing that enhances accessibility. Tall trees provide shade to the surrounding grassy area.

Home in Lyon

4.94 out of 5 average rating, 18 reviews

Guitar Frenchie’s Corner!

Take it easy in the heart of the Delta! This bungalow/ shotgun house is the perfect getaway for Blues lovers who want all the fun that Clarksdale’s home of the Blues has to offer and the quaint and quiet of old town Lyon, birthplace of Son House! Located 5min from the heart of Downtown Clarksdale MS. Come see us & hear great Live music!