
House vacation rentals in Lake City
Find and book unique houses on Airbnb
Top-rated house rentals in Lake City
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Lake City house rentals
House rentals with a pool

Oysters Pearl 4BR Oceanfront Beach Home Grand Porc

Large Private Ranch W/ Pool

Low Country Lux

Eagle Point Retreat W/Pool

Wyboo Retreat at Lake Marion W/Pool

Luxury Lakefront Chalet W/Pool, Hot Tub & Beach

Pawleys Sea Life - Prvt Pool Hot Tub 5 BRs Dogs OK

Heated Indoor Pool on Lake Marion with Dock
Weekly house rentals

Crystal Place Near MUSC and Mcleod Hospital

Charming and spacious 4-bd 2 full ba WiFi, AC

Cozy One Story Town House

Home on Broad

Bungalow near downtown & parks

Nesmith farm house

* NEW * Cozy and Clean 3B/2Bath

Sleeps on the Creek!
Private house rentals

Collins Quarters

The Oasis

Spacious 3-Bed Home w/ Deck

Peaceful Country Getaway

Peaceful Pine Stays/ 5 min. from Mcleod hospital

Lovely Cottage Close to Downtown w/EV chargers

*NEW* COZY RETREAT, 5 minutes from SHAW & Sumter!

Cozy 3 Bedroom Home! Located NEAR MUSC-Florence
Destinations to explore
- Western North Carolina Vacation rentals
- Atlanta Vacation rentals
- Myrtle Beach Vacation rentals
- Charleston Vacation rentals
- Outer Banks Vacation rentals
- Gatlinburg Vacation rentals
- Charlotte Vacation rentals
- Virginia Beach Vacation rentals
- Hilton Head Island Vacation rentals
- Savannah Vacation rentals
- Jacksonville Vacation rentals
- Pigeon Forge Vacation rentals
- Myrtle Beach Boardwalk
- Love's a Beach
- Huntington Beach State Park
- Garden City Beach
- Arrowhead Country Club
- Myrtle Beach National
- Caledonia Golf & Fish Club
- Myrtle Beach State Park
- Broken Groin
- Litchfield Beach and Golf Resort
- Whispering Pines Golf Course
- Litchfield Country Club
- Shipyard Village Building A - Litchfield By The Sea
- Tupelo Bay Golf Center
- Pawley's Island parking lot South
- Prestwick Country Club
- Debidue Beach
- Wild Water & Wheels
- Palm Plantation
- Hyman Vineyards
- Ceremony - Huntington Beach State Park