
Vacation rentals in Florence County
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Top-rated vacation rentals in Florence County
Guests agree: these stays are highly rated for location, cleanliness, and more.

Kuker Cottage Downtown Florence-Near I95 & I20
Kuker Cottage is a beautifully restored Florence home in the heart of downtown. Perfectly situated halfway between New York and Florida, it is an ideal overnight stopping point. Plenty of space to spread out, offering families room to unwind after a long day of traveling. This home has been beautifully updated and is ready to host you, whether for a short or an extended stay. 2 queen beds, one twin bed, full bath, kitchen, wifi and TV. Walkable to parks and restaurants. 4 miles from I95 and I20
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Gated and Private Catholic Hermitage house
Saint Michael Hermitage and retreat is a serene, gated, private home that is for 1-3 guests looking for a quiet stay while traveling or as a retreat destination. You will self check into your Hermitage after you obtain a gate code. There is a prayer chapel close by on the property. It is pet friendly for a well trained pet. There is Catholic iconography throughout the home. It is warm and inviting. There is a full kitchen, washer/dryer for your convenience and complementary coffee/tea.
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Charming Home in Florence, SC
Welcome to Florence, South Carolina! This inviting 3-bedroom, 2-bathroom home is a haven of comfort and convenience. With four queen beds, it comfortably accommodates a group of friends or family. Step into the fully stocked kitchen, relax in the cozy living space, equipped with smart TVs for entertainment. The fenced backyard offers both privacy and a secure play area for your furry friends. Enjoy outdoor gatherings at the picnic table. Convenient amenities include a washer and dryer.
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The Cottage at Dream Acres & Petting Zoo I-95/I-20
The Cottage at Dream Acres is situated with its own private drive on our 8 acre working horse farm located near Florence SC at the I-20/ I-95 corridor, 5 mins off the highway. We are the 1/2 way point between NY & FL. Relax and unwind from a long roadtrip or take a weekend farm-stay getaway. All the amenities of a larger home with the convenience of a smaller studio space! Family Friendly; sleeps up to 4, newly renovated in 2020, petting zoo, outdoor fire pit, tree swing, picnic table!
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Cozy Florence Retreat Near Civic Center & I-95
Welcome to your Florence getaway! This bright, modern, and cozy Welcome to your Florence getaway! This bright, modern, and cozy home is perfectly located near I-95, Downtown Florence, the Florence Civic Center, and Darlington Raceway. Enjoy shopping and dining at nearby Buc-ee's, or take a short 1.5-hour drive to Myrtle Beach. The home features a fully equipped kitchen, comfortable bedrooms, and convenient parking—ideal for road trips, events, family stays, or a relaxing Southern escape.
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Timeless cottage, fresh air and private
This cottage stands out for the privacy and surroundings, perfect spot for a quick get away or for work. Located on an 80 acre farm on its own private spot, yet a short drive to Florence or Lake city. Enjoy amazing sunsets , an ocasional deer, and other wildlife from your front or back porch, no neighbors . Dine in one of the many restaurants in Florence, or stay in and grill out while sitting in your porch surrounded by nature , then wait for the sunset, it won’t disappoint !
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Quiet farmhouse near the beach
The best memories are made on the farm. Life is just better away from the hustle and bustle of city lights and busy schedules. Come stay in this recently renovated fourth generation 1950s farmhouse on an 80 acre working farm. Unwind on the porch, walk trails, find millions of years old sharks teeth, build a bonfire, pick blackberries, swim in the ponds, collect walnuts, or just relax while you’re here but don’t forget to wish on a dandelion or a shooting star before you leave.
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King Bed Close to I-95
Located just 5 mins from I-95 and 12 minutes from Florence, this quaint cottage sits on 6 acres with private deck, firepit & large back yard in a peaceful, country location. Your pets are welcome (max of 2, pls) but are not allowed on our beds. 🧺. King bed in master, 3 TV's (two 55” & one 32”), coffee bar with Keurig, strong WiFi. We also use 100% cotton sheets and quilts for your maximum sleeping comfort. ABSOLUTELY NO SMOKING OR VAPING ON OUR PROPERTY ($200 extra fee)!
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Enchanting Treehouse with Modern Amenities
Perched on 20 acres along Catfish Creek, this enchanting tree house allows you to appreciate nature from a birds eye view. Whether it’s kayaking, canoeing, or exploring along the creek; relaxing in the hammocks and swings; engaging in a board game; or roasting marshmallows at the fire pit, Amenities include a full kitchen with full bath, outdoor shower, booth seating in dining table for up to 8, 2 bunk beds and loft style sleeping. Conveniently located 20 minutes from I-95.
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Historic Southern Charm. Walk downtown!
Experience southern hospitality in this historic charmer perfect for professionals. •Quaint, quiet downtown neighborhood walkable to restaurants •Fast wifi, laundry room, large fenced backyard w/ fire pit, off-street parking •Fully loaded kitchen, queen sleeper sofa, relaxing front porch •TV's in living room and bedroom •3 min to FMU Performing Arts Center, 5 min to McLeod Hospital, 10 min to FMU & MUSC Medical Center. Perfect for short or long stays!
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Cottage by the Pool: Close to Interstates
Palm Trees, colorful flowers, hammocks and quiet space await in this tropic-like oasis just minutes from I-95/20. Hundreds of reviews acknowledge this idyllic setting. We are a Florence Airbnb favorite for travelers. We offer a queen bed, full bathroom, full sleeper sofa, strong wifi and TV. We even provide breakfast bars and coffee to help you jump start your day as you set off for the next journey. We look forward to hosting you.
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Clean Cozy Cottage near I-20 & I-95
Quiet stay in the middle of Florence in this well established, peaceful neighborhood! Only 9 minutes from I-95 and I-20! Only 10 minutes to downtown Florence and 13 minutes to McLeod Regional Medical Center. Large, private, fully fenced in backyard Coffee bar w/ Keurig Strong, fast WiFi Smart TVs in Living Room and Master Bedroom Brand new appliances in kitchen For families: Pack N Play and basket full of toys.
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Popular amenities for Florence County vacation rentals
Other great vacation rentals in Florence County

The Hideaway at Fox Fields
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Saved by Grace Retreat 2 Rustic Creekside Cabins
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Cozy 2BR Near McLeod & MUSC | Pet-Friendly
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Quiet Townhome | King Bed | Easy I-95/I-20
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Peaceful cabin retreat! Collins Quarters
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Chandler Experience
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Sleeps on the Creek!
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Go With the Flo
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Destinations to explore
- Myrtle Beach Boardwalk
- Garden City Beach
- Huntington Beach State Park
- Broadway at the Beach
- Myrtle Beach State Park
- Family Kingdom Amusement Park
- Myrtle Beach SkyWheel
- Myrtle Waves Water Park
- Caledonia Golf & Fish Club
- Lakewood Camping Resort
- Murrells Inlet Marsh Walk
- WonderWorks Myrtle Beach
- Hollywood Wax Museum
- Captain George's Seafood Restaurant
- The Bowery
- Pelicans Ballpark
- Atalaya Castle
- Medieval Times Dinner & Tournament
- Topgolf
- Wild Water & Wheels
- Broadway Grand Prix
- The Pavilion Park
- Conway Riverwalk
- Ripley's Aquarium of Myrtle Beach





