Villa vacation rentals in Isle of Palms
Find and book unique villas on Airbnb
Top-rated villa rentals in Isle of Palms
Guests agree: these villas are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Isle of Palms villa rentals
Villa rentals with a pool
Villa in Saint Helena Island
4.99 out of 5 average rating, 70 reviewsLittle Palm Villa | Oceanfront
Apr 4 – 11
Villa in Seabrook Island
5.0 out of 5 average rating, 12 reviewsClose to beach, pools,golf & tennis+Amenity Card*
Feb 3 – 10
Villa in Seabrook Island
4.92 out of 5 average rating, 87 reviewsGreat Rates! Screen Porch! Pool!
Nov 24 – Dec 1
Villa in Seabrook Island
4.91 out of 5 average rating, 11 reviewsLuxury Seabrook Isl Beach Condo
Dec 17 – 24
Villa in Saint Helena Island
4.99 out of 5 average rating, 80 reviewsSandy Toes Condos
Oct 27 – Nov 3
Villa in Seabrook Island
4.83 out of 5 average rating, 59 reviewsPrivate island villa with luxury resort amenities!
Nov 2 – 9
Villa in Seabrook Island
4.9 out of 5 average rating, 31 reviewsUpscale Villa, Amenity Included! Dog Friendly
Jan 26 – Feb 2
Villa in Seabrook Island
4.85 out of 5 average rating, 34 reviewsSeabrook Golf View Villa: Pickleball, Bike & Pool
Oct 24 – 31
Private villa rentals
Villa in Kiawah Island
4.96 out of 5 average rating, 98 reviewsSpacious new 2BR Villa across beach near Sanctuary
Mar 12 – 19
Villa in Kiawah Island
4.93 out of 5 average rating, 96 reviewsClean & Comfortable! Steps to the beach!
May 12 – 19
Villa in Seabrook Island
4.57 out of 5 average rating, 7 reviewsBeach and Golf Paradise | Vaughan Villa
Jan 29 – Feb 5
Villa in Edisto Island
4.73 out of 5 average rating, 52 reviewsLoft-e-Lagoon *No Cleaning Fee*
Jan 23 – 30
Villa in Kiawah Island
4.97 out of 5 average rating, 88 reviewsLagoon view villa with office, easy walk to beach!
Oct 15 – 22
Villa in Edisto Island
4.97 out of 5 average rating, 36 reviewsRelax in a Happy Place
Sep 18 – 25
Villa in Seabrook Island
4.86 out of 5 average rating, 51 reviews711 Spinnaker centrally located to EVERYTHING!
Jan 19 – 26
Villa in Isle of Palms
4.76 out of 5 average rating, 25 reviewsBeachfront IOP Villa with Outdoor Pool. Remodeled!
Jan 15 – 22
Luxury villa rentals
Villa in Johns Island
4.75 out of 5 average rating, 4 reviewsOceanfront! Renovated, Easiest Beach Access
Oct 12 – 19
Villa in Kiawah Island
5.0 out of 5 average rating, 26 reviewsOcean Front! Beach is steps away. Clean and Crisp!
Jul 27 – Aug 3
Villa in Kiawah Island
5.0 out of 5 average rating, 15 reviewsOceanfront Windswept Villa
Aug 23 – 30
Villa in Isle of Palms
5.0 out of 5 average rating, 4 reviewsOceanfront Villa in Wild Dunes! Community Pool!
Jul 20 – 27
Villa in Kiawah Island
4.89 out of 5 average rating, 18 reviewsSpacious Penthouse 3BR 3Bath Villa with Ocean View
Nov 26 – Dec 3
Villa in Johns Island
5.0 out of 5 average rating, 3 reviews3 Bedroom 2 Bath Duneloft Villa! Neighborhood Pool
Jul 29 – Aug 5
Villa in Folly Beach
4.56 out of 5 average rating, 27 reviews4BR Oceanfront 2nd-Floor | Balcony | Pool
Oct 21 – 28
Villa in Kiawah Island
4.94 out of 5 average rating, 52 reviewsOpen floor plan 2 Bedroom Turtle Cove Villa
Dec 23 – 30
Quick stats about villa rentals in Isle of Palms
Total rentals
70 properties
Rentals with dedicated workspaces
40 properties have a dedicated workspace
Rentals with a pool
70 properties have a pool
Family-friendly rentals
60 properties are a good fit for families
Total number of reviews
1.3K reviews
Nightly prices starting at
R3,145 ZAR before taxes and fees
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- Rentals with outdoor seating Isle of Palms
- Rentals with pools Isle of Palms
- Rentals with a patio Isle of Palms
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