Guesthouse vacation rentals in Greenville County

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Greenville County guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Guesthouse in Travelers Rest
5 out of 5 average rating, 48 reviews

Travelers Rest Country Retreat Two miles to NGU

PeggyRating, 5 stars9 months ago
I can't say anything negative about Cliff and Mary's place. It is a gem. You watch horses graze on one side of the house and overlook a pond on the other side. Cliff and Mary are very responsive and go out of their way anticipating their guests needs, stocking the kitchen and fridge with snacks, coffee, cream, and other goodies. Any questions we had about the area were answered immediately. They are pleasant people that I would be glad to call new friends!
Top guest favorite
Guesthouse in Tryon
4.98 out of 5 average rating, 111 reviews

Historic Jockey Cottage, TIEC 20 mins, Tryon 5

CourtenayRating, 5 stars4 weeks ago
I’m selfishly not wanting to write this great review because I will be sad if the place is booked when I go back to Tryon! The place was perfect for my pup and I while showing at TIEC. The hosts are lovely, and the place stocked with a coffee bar and water, and the community itself is beautiful. Quiet, peaceful, yet super convenient for restaurants and shopping. I will be back! Also, apologies. I stole your box of tissue under the bathroom sink because my allergies were killing me at the horse show: I meant to replace it with one I night but I forgot this morning. I apologize again and thank you!
Guest favorite
Guesthouse in Pendleton
4.89 out of 5 average rating, 264 reviews

La Bella Farm

BrandonRating, 5 stars3 weeks ago
Had an amazing time at this gorgeous space. It was exactly as advertised, and Jessica was extremely responsive and proactive as a host. Thank you so much! Will definitely book there again!
Top guest favorite
Guesthouse in Liberty
4.93 out of 5 average rating, 197 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

RittaRating, 5 stars1 month ago
Jen’s Hideaway is the perfect private spot to come back to after visiting Central and Clemson. It is extremely clean and well appointed. The bed is very comfortable. Jen is a friendly host. She even baked us delicious blueberry muffins.
Guest favorite
Guesthouse in Simpsonville
4.94 out of 5 average rating, 244 reviews

Private Suite in Downtown Simpsonville

DarlaRating, 5 stars3 weeks ago
I had a great stay in Simpsonville, SC. Everyone was very helpful and polite. Thank you!
Guesthouse in Greenville
4.78 out of 5 average rating, 46 reviews

Quiet Guest Apartment in the Woods

JenniferRating, 5 stars32 months ago
Miranda's guest apartment was perfect for a long term stay. It was well equipped, neat, and ideally located with easy proximity to Paris Mountain State Park as well as downtown Greenville. Miranda was a wonderful host and prompt to respond the few times I needed something.
Top guest favorite
Private room in Pelzer
4.98 out of 5 average rating, 129 reviews

South Oaks Guesthouse

MelissaRating, 5 stars1 week ago
Diane’s home is lovely! T It was relaxing, comfortable and welcoming! We will stay again!

Guest house rentals with a patio

Guest favorite
Guesthouse in Lyman
4.94 out of 5 average rating, 32 reviews

Budget Bliss: Cozy Elegance

Jonathan Rating, 5 stars1 month ago
Was very nice and cozy. the water pressure was perfect. host was super friendly and responded quicker than I expected. had great air conditioning so I never got hot. overall pleasent stay! the only downside I discovered was for some reason Domino's wouldn't deliver to that area, but that's Domino's fault, not the host. would definitely stay again!~
Top guest favorite
Guesthouse in Travelers Rest
4.86 out of 5 average rating, 7 reviews

Guest Cottage with Private Drive

RobertRating, 5 stars3 weeks ago
Dustin was easily accessible and quickly responsive when I had questions. his accommodations at the cottage far exceeded my expectations. I would definitely recommend for other guests to try it out. and if in the area again I would definitely try to stay there. highly recommended.
Guest favorite
Guesthouse in Greenville
4.9 out of 5 average rating, 70 reviews

Chic Studio with Private Deck

TemperanceRating, 5 stars1 month ago
This is hands down the BEST air bnb in the Greenville area for couples to enjoy a romantic getaway. Very nice secluded location, within a few minutes of tons of restaurants and retail stores and the cleanliness is top tier. Will definitely be booking any time we come to visit Greenville!
Top guest favorite
Guesthouse in Pelzer
4.98 out of 5 average rating, 45 reviews

Serene country escape on 11 acres-15% off last min

CourtneyRating, 5 stars3 weeks ago
Quiet, peaceful, stay. Amy was very responsive and helpful with local recommendations. We enjoyed our stay with our two dogs, felt right at home!
Top guest favorite
Guesthouse in Easley
5 out of 5 average rating, 51 reviews

Fun, cozy cottage for two w/games, deck in Easley

LinaRating, 5 starstoday
Very cozy place. Always clean and smells fresh. Very friendly and welcoming hosts, check in was smooth and easy to find. Will definitely be coming back again!
Top guest favorite
Guesthouse in Greer
4.96 out of 5 average rating, 51 reviews

Sugar Creek Retreat

ChristopherRating, 5 stars1 day ago
We throughly enjoyed our stay at Kristen’s place. It was everything that was advertised and was very well worth the price paid. Lost to do within vicinity of the location. We were in town for a baseball tournament, which games were located all over the area, and it was very well situated to accommodate our travels. Kristen and her husband were very friendly and very responsive when questions were asked. Definitely recommend if in town.
Top guest favorite
Guesthouse in Greenville
4.95 out of 5 average rating, 40 reviews

Tranquil 2BR Guest House on Pond by Furman

GinnyRating, 5 stars2 weeks ago
Our stay at Gabriella's was wonderful. It is close enough to major roads to get anywhere quickly yet in a quiet neighborhood and very private. The living room was comfortable, the kitchen was well equipped, the bedrooms were large and everything was beautifully decorated. With family new to the area, I've already asked to stay there again!
Guest favorite
Guesthouse in Greenville
4.92 out of 5 average rating, 72 reviews

Historic Earle Street Guest House

CharlotteRating, 5 stars2 days ago
Todd's place was extremely nice! The space was extremely clean and cozy. It was well put together and walkable to a lot of other restaurants, activities and to downtown. I would recommend visiting Greenville and staying at Todd's place!

Guest house rentals with a washer and dryer

Superhost
Guesthouse in Travelers Rest
4.8 out of 5 average rating, 20 reviews

Quiet King Two Bedrm House

LESLIERating, 5 stars2 months ago
This was a quiet spot with friendly neighbors. Be careful if you walk to Travelers Rest as some dogs are off leash. One chased me onto a porch. This was a cross street to the rental location. The rest of the stay was nice and the hosts were very accommodating!
Guest favorite
Guesthouse in Taylors
4.96 out of 5 average rating, 72 reviews

The oaks cottage

EdnaRating, 5 stars1 month ago
Just amazing. Close to everything. It was perfect.
Guest favorite
Guesthouse in Taylors
4.97 out of 5 average rating, 140 reviews

Just off Main near Taylors Mill - Clean & Comfy

CathyRating, 5 stars1 month ago
We were in town for family events. Natalie’s place was exactly as described, clean and spacious for my Mom, husband and I. Fully equipped kitchen , comfy living area and plenty of linens. Check in instructions were clear and Natalie was easy to communicate with. Would stay again if the opportunity arises.
Guest favorite
Guesthouse in Duncan
4.98 out of 5 average rating, 63 reviews

Adorable renovated private house w/ parking.

LisaRating, 5 stars3 months ago
Great place to stay!
Top guest favorite
Guesthouse in Mauldin
5 out of 5 average rating, 9 reviews

Beautiful guest house

RavynRating, 5 stars1 month ago
Great stay! Perfect for a weekend close to the city.
Guest favorite
Guesthouse in Greenville
4.96 out of 5 average rating, 97 reviews

Nishleigh's Nook - West End Downtown Greenville

Jonathan StewartRating, 5 stars3 days ago
Such a great find, and walkable to W. Greenville, Unity Park, Swamp Rabbit Trail, West End, and the south end of downtown. The space was well-appointed, clean, and with your own back entrance opposite the main house, felt very private. Looking forward to staying at Nicholas and Ashleigh’s place again the next time we’re in GVL!
Top guest favorite
Guesthouse in Greenville
5 out of 5 average rating, 14 reviews

800 Sq Ft close to downtown

NickRating, 5 stars4 days ago
A nice spot for a quick night's rest. very clean. Although a kinda wet dog smell. The unit did have a dehumidifier and air purifier which helped.
Top guest favorite
Guesthouse in Greenville
4.99 out of 5 average rating, 298 reviews

Prime Downtown Home—Walk to Main St, Trails&Dining

ArleneRating, 5 stars18 months ago
The loveliest space imaginable. It is so well built, a custom home, the floors, the cabinets, the tile, everything was so classic and comfortable and well appointed. Walked to and from the Peace Center for a show and walked all over town, very safe, very clean neighborhood. Fabulous stay! Ready to plan the next trip back.

Destinations to explore