
Hotel vacation rentals in Downtown
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Top-rated hotel rentals in Downtown
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Downtown hotel rentals
Family-friendly hotel rentals

Old Town Hotel Room - 2 beds - Breakfast Included

Relax and Recharge! Pool, Beach Access, Parking!

Ocean Beach - Bed in 6-Bed Female Dorm

Cozy Twin Room w/ Ensuite Bath, Desk & A/C in SD

Studio 2 Queen Beds at Hard Rock Hotel San Diego!

Pet-friendly Hotel with Free Breakfast and Pool!

Greely Gaslamp - Loft w Parking & 3 Beds #302

Ocean Beach - Bed in 6-Bed Mixed Room
Hotel rentals with a pool

Recently reno’d escape near the Gaslamp Quarter

Convenient Base Near San Diego Zoo & Balboa Park

Marriott At San Diego - Studio

Iconic Resort in San Diego

Playful escape near games & concerts at Petco Park

Studio San Diego Marriott

Chula Vista Fun in the Sun

Downtown Delight: Pets Allowed, Parking, Pool!
Hotel rentals with a patio

Coronado Beach Resort July 6-13

Modern King Room | Luxe Stay in Little Italy

WorldMark Inn at the Park

Club Wyndham Harbour Lights

Queen Studio in Central Little Italy (Patio)

Charming 1 bedroom resort steps away from beach

Comic-Con 2026: Spacious King Suite + Sofa Bed

ITH Mission Beach Backpacker Hostel Mixed Dorm
Quick stats about hotel rentals in Downtown
Total rentals
260 properties
Nightly prices starting at
R707 ZAR before taxes and fees
Total number of reviews
4.2K reviews
Family-friendly rentals
60 properties are a good fit for families
Pet-friendly rentals
90 properties allow pets
Rentals with a pool
160 properties have a pool
Destinations to explore
- Rentals with an EV charger Downtown San Diego
- Rentals with pools Downtown San Diego
- Rentals with a fire pit Downtown San Diego
- Rentals with a hot tub Downtown San Diego
- Rentals with beach access Downtown San Diego
- Fitness-friendly rentals Downtown San Diego
- Townhouse rentals Downtown San Diego
- Serviced apartment rentals Downtown San Diego
- Rentals with breakfast Downtown San Diego
- House rentals Downtown San Diego
- Waterfront rentals Downtown San Diego
- Smoking-friendly rentals Downtown San Diego
- Apartment rentals Downtown San Diego
- Loft rentals Downtown San Diego
- Rentals with a fireplace Downtown San Diego
- Rentals with a home theater Downtown San Diego
- Rentals with a patio Downtown San Diego
- Rentals with a beach view Downtown San Diego
- Rentals with a washer and dryer Downtown San Diego
- Condo rentals Downtown San Diego
- Family-friendly rentals Downtown San Diego
- Pet-friendly rentals Downtown San Diego
- Rentals with outdoor seating Downtown San Diego
- Rentals with a sauna Downtown San Diego
- Hotel rentals San Diego
- Hotel rentals San Diego County
- Hotel rentals California
- Hotel rentals United States
- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Pacific Beach
- Tijuana Beach
- SeaWorld San Diego
- Coronado Beach
- LEGOLAND California
- University of California San Diego
- San Diego Zoo Safari Park
- Balboa Park
- La Misión Beach
- Oceanside Harbor
- Coronado Shores Beach
- Black's Beach
- Belmont Park
- Moonlight Beach
- Sesame Place San Diego
- Liberty Station
- Law Street Beach
- Torrey Pines Golf Course
- USS Midway Museum
- Mission Beach
- Santa Monica Beach