Vacation rentals in Southside, Jacksonville

A spacious common area features large windows allowing natural light to fill the room. A cozy sectional sofa is arranged around a coffee table, complemented by elegant decor. The two-story ceiling enhances the openness, while a staircase leads to another level of the building.

4.85 out of 5 average rating, 55 reviews

Lux King Bed Stunning View Pool Mayo Clinic Beach

Start your Jacksonville stay with comfort and style! This modern 1-bedroom apartment in a prime location puts you just 10 minutes from Mayo Clinic and 15 minutes from the beach. You’ll enjoy a fully equipped kitchen, a cozy bedroom, and a stunning view that will elevate your experience. Whether you’re here for treatment, work, or a beach escape, you’ll find everything you need for a relaxing, stress-free stay. Enjoy the comfort, convenience this apartment offers for a seamless long or short stay

Superhost

A serene beach scene showcases soft waves lapping against the shore under a clear blue sky. A lone figure is seen distantly walking along the water's edge, while several seagulls gather on the wet sand, reflecting the sunlight.

Tiny home in Southeast Jacksonville

4.84 out of 5 average rating, 309 reviews

Private yard, all secluded tiny house-your oasis!

Come play at the beach! 24’ tiny house on a private fenced yard with gas grill, tropical outdoor area for relaxing. Lofted sleeping space, with shower and toilet make this the perfect weekend getaway or the escape from work meetings. Close to Mayo Clinic, Downtown , & Florida Beaches all a 15 minute drive! Or enjoy Orlando and natural springs with manatees couple hours away. St Johns town outdoor mall is a 5 minute drive and has countless food and shopping options! Truly a unique experience!

Home in Southeast Jacksonville

The entrance displays a black door adorned with a seasonal wreath featuring greenery. A welcome mat with a checkered design is positioned at the foot of the door, enhancing the home’s inviting appearance. The house is surrounded by a neatly maintained lawn.

4.96 out of 5 average rating, 300 reviews

Coastal Lane 3/2 Clean Home in Jacksonville, Wi-fi

Reach out about our multi day discounts for weekdays! This gorgeous 3 bedroom coastal style home is your home away from home! Located in a peaceful and quiet neighborhood with perfect lake views. It's close to shopping, stores, and restaurants. - Easy highway access right off I-95 - 15 minute drive from the Jacksonville Jaguars Stadium (TIAA Bank Field) - 20 minute drive to Jacksonville Beach - 25 minute drive to Jacksonville Airport - Fast Wi-Fi -EV Charge Available for Guests in Garage

Guesthouse in Southeast Jacksonville

A black wrought iron gate stands closed, providing access to a paved path leading to the guest suite. White siding is visible on the adjoining building, while nearby greenery contributes to a natural setting. The scene is set under a clear blue sky.

4.92 out of 5 average rating, 271 reviews

Studio Suite in Beautiful Central Neighborhood

Studio guest suite with queen bed and kitchenette in beautiful Miramar neighborhood, just 5 minutes from historic San Marco. Close to restaurants, grocery, MD Anderson Cancer Center and Wolfson Children's Hospital. Owners live in main house on site but suite has its own private entrance and parking. You will have access to an outdoor dining space and fenced in backyard. Dogs live on premises but will not interfere, although you may hear barking. Sofa bed available if needed, please inquire.

A dedicated movie theater room is equipped with a large screen and multiple comfortable recliner seats, arranged for optimal viewing. The walls feature a dark color scheme, enhancing the cinematic experience, while a low platform adds to the tiered seating layout.

4.95 out of 5 average rating, 223 reviews

Top floor modern getaway w/resort amenities!

New build! Entire modern, luxurious, and spacious apartment. Stunning lake-front view with gorgeous sunsets. Large king bed and queen sleeper sofa provide a comfortable stay for 4. Whether your stay includes a day of shopping, a trip to golf, going to work, or to unwind at the beautiful Jacksonville beaches, you are never far from your destination. Less than 5 miles to the St. Johns Town Center, 7 miles to the nearest hospital, 11 miles to the beaches, and 6 miles to the nearest golf course.

An indoor lounge area features a billiards table at the center, surrounded by minimalist furniture. Large windows allow natural light to fill the space, revealing views of a swimming pool and tropical landscaping just outside.

5 out of 5 average rating, 12 reviews

Red Sails oasis, just minutes from Mayo Clinic

Enjoy a peaceful experience at this centrally-located apartment with all inclusive, resort-like amenities located in Jacksonville, Florida. We are just off of the main highway just minutes from the Mayo Clinic, UNF, and the St. Johns Town Center. * Covered garage parking and elevator access makes it easy to come and go! Take a dip in the beautifully welcoming pool, work out in the fully equipped, 2-story gym, or you can handle your business in the office spaces. There's so much more!

5 out of 5 average rating, 110 reviews

A welcoming entrance features a beige exterior wall with a neat stairway ascending to the apartment. A potted plant adorns the side, while a doormat with 'Welcome' text creates an inviting atmosphere. Natural light filters in through the open door, highlighting the entryway.

Loft in Avondale

Bright stylish 1bd/1 ba Apt in Historic Avondale.

You'll love this bright stylish second-floor apartment only steps away from the historic Shoppes of Avondale's bars and restaurants. This one bedroom, one bath is so inviting. The open floor plan with windows on all sides provides a bright and airy feel. Amenities such as off-street parking, ensuite washer and dryer, remote workspace, and fully equipped kitchen provide at-home conveniences. Rest and relax in a king-size bed after taking a hot shower or relaxing bath.

Guesthouse in Jacksonville

A cozy outdoor seating area features two woven chairs with accent pillows, paired with a coffee table. The space is paved with square stones, surrounded by lush greenery, creating a sense of privacy and tranquility.

4.96 out of 5 average rating, 100 reviews

The Little House on Jupiter

Good vibes only at La Casita. Stylish, peaceful & private. When it comes to choosing your home away from home- the details matter. Kitchen is equipped with fridge, microwave, air fryer and hot plate. Coffee, hand soap, dish detergent, shampoo and conditioner provided. The bed is full sized. Enclosed side yard. Excellent central location. 10 minutes to the highway, St. John’s Town Center & UNF. 20 minutes to the beaches, downtown & Mayo. No smoking is permitted inside.

A large swimming pool is surrounded by sun loungers with a vibrant yellow finish. Lush palm trees line the area, complementing the well-maintained landscape. The building façade is visible in the background against a bright sky with scattered clouds, adding to the inviting atmosphere.

4.92 out of 5 average rating, 12 reviews

Bikini Bottom @ 1307 Near Mayo Clinic.

Discover the perfect blend of comfort and style at Bikini Bottom @1307 🔹Swimming pool with loungers 🔹BBQ Grills 🔹Movie Theater, Clubroom with TVs & Billiards 🔹Private office & Conference Room 🔹Vehicle E-Charging Stations 🔹Free covered parking 🔹Elevator & Wheelchair Accessible 🔹 🔹 BEFORE YOU BOOK 🔹 🔹 The apartment complex requires a background check on all it’s guest. After your reservation is confirmed, we kindly ask that you complete a short form.

Guest suite in Southwest Jacksonville

A softly illuminated walkway is visible, guiding towards a fence and greenery. The path is bordered by fresh landscaping, with subtle lighting that enhances the serene outdoor atmosphere during the evening.

4.89 out of 5 average rating, 245 reviews

Stylish Private Master Suite With Private Entrance

PLEASE READ BEFORE BOOKING: *This suite is apart of a duplex. It is attached to another Airbnb, however this Airbnb space is NOT shared with others. You will have this private place to yourself and just your guest will be in it with you. We all stayed at places while on vacation in cities that are far from entertainment at least once. The Riverside area is full of different restaurants, attractions, and entertainment options that will keep you full & entertained.

Guest suite in Southeast Jacksonville

4.87 out of 5 average rating, 171 reviews

Cozy Entire Suite / Studio Completely Private

Mandarin Room is a peaceful and cozy retreat where privacy and comfort come together. Recently remodeled, this room has a private entrance and bathroom, giving you freedom and serenity. Its warm, modern vibe invites you to disconnect from the world. Enjoy a restful sleep in a space designed to refresh you. Whether you're here for work or just to relax, it's the perfect spot to unwind. Come, make Mandarin Room your personal sanctuary. Your perfect getaway awaits!