Vacation rentals in Southside, Jacksonville

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Top-rated vacation rentals in Southside, Jacksonville

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Superhost

A large swimming pool occupies the center of a well-maintained outdoor area, surrounded by lush palm trees and landscaped gardens. Sun loungers are arranged around the pool, offering ample seating for relaxation. The surrounding buildings feature a modern design with colorful accents.

Apartment in Southeast Jacksonville

4.83 out of 5 average rating, 24 reviews

The Sea @ 1319 Near Mayo Clinic

Immerse yourself in comfort at The Sea @1319, a beautifully designed one bedroom/one bath luxury apartment. 🔹Swimming pool with loungers 🔹BBQ Grills 🔹Movie Theater, Clubroom with TVs & Billiards 🔹Private office & Conference Room 🔹Vehicle E-Charging Stations 🔹Free covered parking 🔹Elevator & Wheelchair Accessible 🔹 🔹 BEFORE YOU BOOK 🔹 🔹 The apartment complex requires a background check on all it’s guest. After your reservation is confirmed, we kindly ask that you complete a short form.

Guest favorite

A spacious common area features large windows allowing natural light to fill the space. A modern sofa with decorative pillows faces a unique coffee table. The open layout leads to an outdoor pool area, with comfortable seating and a staircase visible in the background.

Apartment in Southeast Jacksonville

5 out of 5 average rating, 17 reviews

StunningAptPool ViewbyStJohns1townCent&MayoClinic

"Discover the perfect getaway in the heart of St. Johns Town Center, Jacksonville! This stylish 1-bedroom apartment offers comfort and convenience, steps away from top restaurants, shopping, and entertainment. Enjoy a beautifully furnished space with a fully equipped kitchen, cozy living area, and access to a stunning pool. Ideal for couples, solo travelers, or business professionals, you'll love the vibrant atmosphere and central location minutes from everything you need for a memorable stay."

Guest favorite

A minimalist studio interior is displayed, featuring a warm wooden beam and a glass dividing wall. A comfortable orange couch is positioned near a window with natural light filtering through. Earthy tones create a calming atmosphere, complemented by a jute rug and layered textiles.

Apartment in Riverside

4.89 out of 5 average rating, 91 reviews

Wabi-Sabi Inspired Studio w Bikes, Walk to River

Tucked away behind a historic building, is a wabi sabi inspired studio: a blend of natural charm & modernity. A minimalist interior features a warm wooden beam, glass dividing wall, and earthy tones. Modern comforts coexist with aged ceramics and jute rugs. Large windows invite natural light and provide a view of the backyard garden. The space embodies tranquility, celebrating simplicity & imperfection. This harmonious retreat offers a peaceful escape, where past & present beautifully converge.

Top guest favorite

A studio guest suite features a queen bed with decorative pillows and a lightweight blanket. A work desk with a bar stool and a mounted TV are visible against the wall. Light wood flooring complements the soft blue wall, while a woven wall hanging adds texture to the space.

Guesthouse in Southeast Jacksonville

4.92 out of 5 average rating, 286 reviews

Studio Suite in Beautiful Central Neighborhood

Studio guest suite with queen bed and kitchenette in beautiful Miramar neighborhood, just 5 minutes from historic San Marco. Close to restaurants, grocery, MD Anderson Cancer Center and Wolfson Children's Hospital. Owners live in main house on site but suite has its own private entrance and parking. You will have access to an outdoor dining space and fenced in backyard. Dogs live on premises but will not interfere, although you may hear barking. Sofa bed available if needed, please inquire.

Top guest favorite

An inviting inground pool is surrounded by a paved deck, featuring a safety gate and pool toys. Lounge chairs are positioned nearby for relaxation. Lush greenery and tall palm trees frame the area, creating a tranquil outdoor environment with clear blue skies overhead.

Home in Southeast Jacksonville

5 out of 5 average rating, 5 reviews

XL family home, Pool, Private 1 acre, super clean!

This well designed large home offers the perfect balance of luxury, comfort, and fun. Great for relaxing and reconnecting in style. Enjoy sun-filled living spaces : A family room with pool table, games, formal dining room, a fully stocked kitchen, coffee nook, pergola with an outdoor grill kitchen setup and an inviting inground pool which is shared with the cottage in the back on the same property. Conveniently located , this home offers space and amenities to make your stay truly memorable.

Guest favorite

A modern living area features a light-colored sofa adorned with dark cushions and a soft throw blanket. A glass coffee table is positioned on a textured area rug, complemented by a stylish floor lamp and a leafy plant beside it. A large abstract artwork adds a striking focal point.

Apartment in Southwest Jacksonville

4.89 out of 5 average rating, 96 reviews

Lake View Escape to The Exchange

Give us your worries and we will give you an escape. Welcome to the Exchange! This Orange Park unit supports your work requirements and your playful desires. Multiple high volume healthcare facilities surround the area and the Naval Air Station is in the backyard. Luxury dinning and outdoor water activities abound. This new unit offers access to a resort style salt water pool, private garages, state of the art fitness center and wellness studio, dog park, clubhouse and lounge, and much more.

Guest favorite

A modern living area features a turquoise sectional sofa accented with yellow cushions. A dining table with four chairs sits in the foreground, complemented by woven placemats. Light streams through large windows, illuminating the space, which includes a television and decorative plants.

Apartment in Southeast Jacksonville

4.86 out of 5 average rating, 105 reviews

Elegant 2 King Bed Southside Pool Mayo Clinic UNF

Enjoy the comfort of a spacious, luxury apartment designed just for you. With two large master suites, King beds, and private bathrooms, you’ll have all the space you need to relax and recharge. You can lounge by the resort-style pool, stay active in the state-of-the-art gym, or explore nearby shops and dining at the Town Center. You’re just 15 min from the beach and close to Mayo Clinic. With easy access to I-295, you’ll love how convenient everything is around you in this prime location

Top guest favorite

The kitchen features white cabinetry with ample storage and a spacious countertop. Stainless steel appliances, including a double oven and dishwasher, are visible. A window allows natural light to illuminate the workspace, and a small area rug adds a touch of warmth.

Guesthouse in Southeast Jacksonville

4.98 out of 5 average rating, 378 reviews

Private Apartment

Unique private upstairs apartment near the beautiful Julington Creek very close to St. Johns, under majestic live oak trees offering a quiet and secluded setting, but close enough to everything you need for your next trip to Jacksonville. Short distance to great dining, beaches, shopping, St. Johns and St. Augustine! Guests will enjoy a one bedroom apartment with a fully equipped kitchen. Property access for our guests only. Complimentary beer, sodas, water and coffee! Adults only.

Top guest favorite

A modern sitting area features a grey sofa with blue accent pillows and a matching chair. A round wooden coffee table sits on a decorative rug with a traditional pattern. Light filters in through sheer curtains, creating a bright and inviting space.

Apartment in Southeast Jacksonville

5 out of 5 average rating, 22 reviews

Red Sails oasis, just minutes from Mayo Clinic

Enjoy a peaceful experience at this centrally-located apartment with all inclusive, resort-like amenities located in Jacksonville, Florida. We are just off of the main highway just minutes from the Mayo Clinic, UNF, and the St. Johns Town Center. * Covered garage parking and elevator access makes it easy to come and go! Take a dip in the beautifully welcoming pool, work out in the fully equipped, 2-story gym, or you can handle your business in the office spaces. There's so much more!

Guest favorite

A spacious bedroom features a large bed adorned with white bedding and blue accent pillows. The walls exhibit a starry night mural, while the windows are draped with golden curtains, allowing soft light to illuminate the room. A mirror is positioned against the wall.

Apartment in Southeast Jacksonville

5 out of 5 average rating, 8 reviews

Serenity Retreat| 1BD Lux King in Southeast Jax

Welcome to your own personal retreat! Let go of the weight of daily life and step into a world of tranquility, where stress fades and serenity takes over. Experience the calming ambiance of a spa like retreat, relaxing music, and soft lighting, all designed to create profound peace. This is more than a stay—it’s a curated experience designed to recharge your spirit, awaken your clarity, and inspire your dreams. Let go, unwind, and manifest your best self. Your escape begins here!

Guest favorite

A modern kitchen with granite countertops and stainless steel appliances opens to a spacious living area. Large windows provide natural light and a view of the outdoors. A comfortable seating area with blue furniture and a dedicated workspace can be seen, enhancing the inviting atmosphere.

Apartment in Southeast Jacksonville

4.95 out of 5 average rating, 230 reviews

Top floor modern getaway w/resort amenities!

Entire modern, luxurious, and spacious apartment. Stunning lake-front view with gorgeous sunsets. Large king bed and queen sleeper sofa provide a comfortable stay for 4. Whether your stay includes a day of shopping, a trip to golf, going to work, or to unwind at the beautiful Jacksonville beaches, you are never far from your destination. Less than 5 miles to the St. Johns Town Center, 7 miles to the nearest hospital, 11 miles to the beaches, and 6 miles to the nearest golf course.

Top guest favorite

The studio features a spacious bed with a light-colored blanket and decorative pillows. A cozy sofa sits in the corner, accompanied by a coffee table. Green plants are placed throughout, and ample natural light enters through a window, complemented by thoughtful décor on the walls.

Apartment in Southeast Jacksonville

5 out of 5 average rating, 121 reviews

The Cozy Basement in San Marco

Make yourself at home in this studio-style apartment located in a quiet neighborhood with a kitchenette and full bathroom that features modern updates. Centrally located, less than 5 minutes from historic downtown San Marco with trendy restaurants and shopping, just minutes away from all the shops and nightlife in the village square. Less than 15 minutes to Riverside and downtown Jacksonville including multiple hospitals. Also only 30 minutes from the airport and beaches.