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House vacation rentals in Santa Cruz de la Sierra

Find and book unique houses on Airbnb

Top-rated house rentals in Santa Cruz de la Sierra

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Top guest favorite
An open living space features a light-colored sofa, coffee table, and accent chairs, complemented by an area rug. The dining area includes a table with high-backed chairs, while the kitchen is visible in the background, showcasing a well-lit and functional layout.
Home in Santa Cruz de la Sierra
4.96 out of 5 average rating, 73 reviews

Nice 2 bedroom house, the best rest.

Charming 2 bedroom house, equipped and decorated in a timeless style. Located in a quiet and ultra-safe condominium, just 10 minutes from Viru Viru Airport and 30 minutes from downtown. Enjoy the comforts of the condominium: Swimming pool with slides Supermarket and ATM within walking distance Gym, saunas, and a hot tub to chill out Walking circuits and tennis and soccer courts to stay active. Ideal for: Relax away from the hustle and bustle A stopover after a flight Families and groups of friends.

Superhost
A modern two-story house is illuminated at dusk, highlighting its stylish design. The exterior features a mix of white brick and wooden accents, with large glass windows that offer panoramic views. A landscaped yard with stone pathways enhances the welcoming entrance.
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 4 reviews

Casa Oasis

Bienvenido a Casa Oasis. Escapa al paraíso con nuestra casa moderna y luminosa en el exclusivo condominio Mar Adentro. Relájate en la piscina privada, disfruta del jardín, y cocina a tu gusto en la cocina totalmente equipada. Con aire acondicionado, Wi-Fi, TV y estacionamiento. Tres cómodos dormitorios, todos con baño privado y cortinas black-out. Además, lavandería, plancha, microondas, licuadora y cama inflable extra. Vive la magia de la laguna artificial y los restaurantes cercanos.

Top guest favorite
A tranquil area is featured, showcasing a large, shimmering lagoon with palm trees lining the shore. Colorful, casual seating is visible on the sandy ground, providing spots for relaxation. The clear blue sky is dotted with a few clouds, enhancing the serene environment.
Home in Santa Cruz de la Sierra
5 out of 5 average rating, 7 reviews

Davezies House, A Unique Experience, Offshore

Discover a unique and surprising place! A house with 2 suites, including an impressive Master Suite. Enjoy spacious and sophisticated spaces in the living room and a fully-equipped kitchenette. Relax in the pool or barbecue area, perfect for sharing unforgettable moments with family and friends. Air conditioning, LCD TV, and WiFi throughout the house. You'll have everything you need. Access to amazing facilities: beach, restaurant, tiki bar, children's playground and more.

Top guest favorite
A spacious living area features a large white sectional sofa adorned with decorative pillows. A dark coffee table sits at the center, surrounded by a plush area rug. A pendant light hangs above, illuminating the space, while a piece of wall art adds a touch of color.
Home in Centro
5 out of 5 average rating, 25 reviews

Centrally located and spacious house 50 meters from 2nd Ring

One-story house with an unbeatable location and well-lit spaces. It has 4 spacious bedrooms (2 en suite). Fully furnished and very well decorated to make you feel at home. Located 50 meters from the 2nd Ring between Av. Alemana and Beni avenues, a safe and easily accessible residential area. Assisted by supermarkets, restaurants, such as the traditional “Casa del Camba” and others. Spacious social areas, living room, dining room, and barbecue. A fully-equipped kitchen.

Superhost
A spacious living area features large windows that offer views of the private pool and surrounding greenery. A modern grey sectional sofa is complemented by colorful cushions, and a sleek glass coffee table sits at the center. Dining and kitchen areas are visible in the background.
Home in Santa Cruz de la Sierra
4.5 out of 5 average rating, 4 reviews

Beautiful new house with pool

Welcome to your home-away-from-home! Enjoy this spacious and comfortable house with private pool, equipped with everything necessary for a perfect family stay. Ideal for families with children, it offers comfortable spaces to relax and disconnect from the city noises. Located in a beautiful condominium surrounded by nature, with an incredible artificial lagoon of over 13 hectares to enjoy. A perfect refuge, full of peace for an unforgettable vacation awaits.

Guest favorite
The two-story house features a terracotta roof and a welcoming entrance. The patio area is paved and includes potted plants. A carport is visible on the right side, providing shelter for vehicles. Surrounding greenery adds a touch of nature to the space.
Home in Santa Cruz de la Sierra
4.92 out of 5 average rating, 13 reviews

Comfortable and safe house SC

The house is very nice, comfortable and safe. Located 12 minutes from historic downtown Santa Cruz. Within walking distance are the Military Engineering School (EMI), the Military Aviation College and the Center cinema. In the surroundings you can find food businesses, pharmacies, mini supermarkets, health centers, urban park, squares and availability of transportation to all latitudes. Excellent location to rest with total peace of mind and security.

Guest favorite
The serene pool area is highlighted by clear blue waters, surrounded by lush palm trees and tropical vegetation. Sunlight reflects off the water's surface, offering a calm and inviting atmosphere for relaxation. The space provides access to nearby facilities and is designed for leisure.
Home in Santa Cruz de la Sierra
4.95 out of 5 average rating, 19 reviews

Condominium house near Fexpocruz for 8

New house, cozy, ideal for a large family, one floor with four bedrooms and four bathrooms, garden, gallery and barbecue to enjoy the outdoors. Enjoy the security of a beautiful condominium with multi-functional courts, a children's playground, a large swimming pool, barbecues with a cabin, a micro market, and private streets with 24-hour security. Located very close to Fexpocruz, a few minutes from downtown and Equipetrol.

Top guest favorite
A spacious bed with a blue upholstered headboard is positioned in the foreground. In the background, a kitchenette features basic cooking appliances, and a small dining table with two chairs is visible. Light enters through a nearby window, illuminating the room.
Home in Centro
4.98 out of 5 average rating, 40 reviews

Comfortable studio apartment in the center

PLEASE read the listing carefully before booking. Spacious, comfortable and centrally located, newly renovated studio for a maximum of two people. It has air conditioning, a 32” smart TV, a kitchen equipped with the basics for cooking not very elaborate meals, a private bathroom and WiFi. Ideal for short stays for leisure or business trips. Many buses pass by the house's door, making it easy for you to get around the city

Guest favorite
A serene outdoor area features a swing adorned with a fabric covering, surrounded by lush greenery. Decorative stone paths lead through a well-maintained lawn, complemented by minimalist landscaping elements, including potted plants and a grilling area built into the wall.
Home in Santa Cruz de la Sierra
4.91 out of 5 average rating, 11 reviews

Minimalista y vintage

Escápate a esta casa minimalista con toque vintage rodeada de naturaleza, dentro de un complejo completo con piscina, cancha polideportiva, tenis y sauna. Perfecto para disfrutar un fin de semana inolvidable en familia a solo 1 0 minutos del aeropuerto y 20 min de la ciudad. Cuenta con parrillero y jacuzzi dentro de la casa y totalmente automatizada

Superhost
A villa is shown with a tiled roof and a spacious outdoor patio. Lush greenery surrounds the area, complemented by palm trees. Glass doors provide natural light and an inviting connection to the exterior. Air conditioning units are visible on the exterior walls.
Home in Santa Cruz de la Sierra
4.91 out of 5 average rating, 11 reviews

House

This House is just 5 minutes from Viru Viru airport, and 10 minutes from the city center. It is 12 minutes from the Hotel los Tajibos. This Village has private access, Electric Gate, BBQ Steakhouse, Pool private, Wifi, Full Kitchen, air condition in All room and living room, Very much like being at home. You can receive visits 24 hours a day.

Top guest favorite
A wooden-paneled hallway leads to a cozy sleeping area with a spacious bed visible in the background. A small round table with black stools occupies the foreground, accompanied by a decorative plant. A side table with ornamental items is positioned along the wall.
Home in Centro
4.92 out of 5 average rating, 118 reviews

Attached Apartment

Welcome to our cozy apartment in one of the most beautiful and secure areas in the downtown! Just 6 blocks away from Plaza 24 de Septiembre, our historic neighborhood offers a unique experience. Although the entrance is shared with the main house, we ensure your privacy and comfort. Enjoy your stay in our wonderful city!

Guest favorite
A landscaped pathway with steps leads down to a serene outdoor area, featuring lush greenery and vibrant flower beds. A large body of water can be seen in the distance, reflecting the clear sky, accompanied by a shaded pavilion nearby.
Home in Santa Cruz de la Sierra
4.86 out of 5 average rating, 51 reviews

Beach house in Santa Cruz

Enjoy a quiet stay in one of the city's most exclusive condominiums: SEA SIDE. Ideal for couples, friends or families, this cozy space is just 7 minutes from town, offering you the perfect combination of comfort and closeness. Relax and disconnect in a privileged environment, surrounded by nature and modernity.

Popular amenities for Santa Cruz de la Sierra house rentals

Quick stats about house rentals in Santa Cruz de la Sierra

  • Total rentals

    470 properties

  • Nightly prices starting at

    R173 ZAR before taxes and fees

  • Total number of reviews

    2.6K reviews

  • Family-friendly rentals

    200 properties are a good fit for families

  • Pet-friendly rentals

    150 properties allow pets

  • Rentals with a pool

    160 properties have a pool

Destinations to explore