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Vacation rentals in Santa Cruz County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The large private deck overlooks expansive high desert mountain views. A grill sits ready for use, accompanied by a small potted plant on a metal cart. Lush greenery frames the view, providing a serene outdoor space.
Apartment in Sonoita
5 out of 5 average rating, 133 reviews

High Desert Wine Country

Take it easy at this tranquil getaway. Breathtaking views, 5000 feet altitude. See wineries or take a day's outing and visit local attractions. Second story apartment is a newly renovated space over hosts' garage (guests must be capable of climbing one flight of spiral stairs). It has a full kitchen (Including dishwasher), full bath (shower only - no tub), nice sized bedroom with queen bed and closet. Second story large private deck. NO DIRT ROADS TO PROPERTY! Adults only and (sorry!) no pets.

Guest favorite
A hammock is gently draped between two trees, with the fabric partially visible in the foreground. The background features a stunning sunset, casting soft hues across the sky. The landscape is open, with sparse vegetation and rolling hills creating a tranquil environment.
Guest suite in Nogales
4.94 out of 5 average rating, 129 reviews

Patagonia Lake Hideaway

PRIVATE SPACE! $105 p nite NO CLEANING FEES but airbnb charges its own fees. king bed, sofa, picture window,french doors, electric fireplace, Private courtyard, patios, gardens,sunrise over Patagonias,sunset behind the Atascosas. Birding paradise.Also great for hunters, hikers.Lake minutes away with boat rentals, swimming, fishing, hiking, small beach. Easy travel toTombstone, AZ Trail, Tubac, Golf Course, Kartchner caverns, Patagonia, Mexico, wine and spirit tasting .check in/check out flexible

Top guest favorite
A spacious room features a comfortable king bed and a cozy seating area with a sofa. Natural light filters through windows, illuminating the neutral colors of the decor. A kitchenette with a coffee maker and a small fridge is also visible, enhancing convenience for guests.
Guest suite in Tubac
4.95 out of 5 average rating, 240 reviews

Private Tubac Retreat under The Milky Way

A tranquil, spacious, and beautiful Casita. Comfortable King bed with a gel memory foam mattress, additional pillows and blankets for your convenience, private bathroom, microwave, small fridge, toaster, coffee maker, and teas and coffee for a quick bite. Private entrance and a small patio with seating area, which leads to the staircase to the roof where you can enjoy the view during the day and the Milky Way at night. Large screen TV with Netflix and Hulu (bring your own passwords), and Wi-Fi.

Guest favorite
A moderate-sized studio is focused on relaxation, featuring a spacious king bed with decorative pillows, a cozy seating area with a dark sofa, and a small dining table. A kitchenette with a mini fridge, microwave, and coffee maker is located adjacent, along with a decorative cabinet.
Guest suite in Patagonia
4.95 out of 5 average rating, 117 reviews

Box T Studio

The Studio is a moderate sized living quarters set up purposely for lounging, relaxing, personal entertainment and rest. Set within the compound of a historical property (The Box T Ranch built in 1902), the studio is the perfect home plate for all your Southern Arizona adventures. It includes an amazing king size bed, comfortable furnishings, a 57" Sony TV, mini fridge, microwave, Keurig, 2 person walk in shower and an AC unit. We are within 5 minute walking distance into town. Perfect getaway!

Guest favorite
The bedroom features a king-size bed with a light blue quilt and two accent pillows. Soft yellow curtains frame the window, allowing natural light to fill the space. Two bedside lamps with red shades illuminate the room, and a framed artwork hangs above the headboard.
Guest suite in Tubac
4.96 out of 5 average rating, 138 reviews

Tubac Golf Resort Casita - long stay discounts

The casita is centrally located between the Tubac Golf Course and Tubac village. The casita has a private bedroom and bathroom with outside entrance with dog door. The beautiful private yard has a covered porch, outdoor kitchen, and chiminea. Inside the casita is a king-size bed, table and chairs, refrigerator, microwave and coffee pot. Amenities include WIFI, local TV, Peacock. Weekly and long stay discounts. Early checkin and late checkout available upon request. Lockbox with code provided.

Top guest favorite
A brass bell is prominently displayed against a dark sky, capturing attention with its polished surface. It hangs from a metallic arm, showcasing detailed craftsmanship, while the surrounding structure is minimally visible in the foreground.
Apartment in Tubac
4.99 out of 5 average rating, 211 reviews

Coolest AirBnB in Tubac-Private Unique Free Charge

Located in the historic district of the village; a Tubac icon. Drive for free ... charge with my Level 2 solar while you're here; house is 100%, solar. Private, secure, best location, warm weather, fast Internet, new and comfy bed, complete kitchen, high quality AC, quaint, free easy parking, washer/dryer, walled courtyard with a fountain, walk-in shower, light blocking shades. Eight excellent restaurants within 1 mile. An exceptional value, best price, no deposit or cleaning fees

Top guest favorite
A dining area features a long wooden table surrounded by six dark chairs. A large chandelier shaped like a star hangs above the table, casting intricate patterns on the walls. A decorative centerpiece of fresh fruits adds a touch of color.
Home in Tubac
5 out of 5 average rating, 123 reviews

A Tubac Getaway

Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!

Top guest favorite
A round mirror framed in metal reflects a cozy sleeping area featuring a colorful blanket on the spacious bed. The rustic brick wall is enhanced by a small natural wood piece placed below the mirror, adding a touch of texture to the interior.
Tiny home in Elgin
4.97 out of 5 average rating, 120 reviews

Private casita on Thunder Mountain Ranch

It's the perfect "getaway" that's still "near" it all! Our stand alone southwestern fully equipped Casita offers comfortable accommodations in a very unique setting, surrounded by thousands of acres of the Coronado National forest. Located in the desirable Sonoita/Elgin area of Southern Arizona. From just soaking up the quiet serenity for a weekend, to an adventure filled longer stay, we can help tailor your experience to enjoy the many different things to see and do in the area.

Top guest favorite
A single-story building constructed with natural stone and warm-toned stucco is set against a backdrop of grassy landscaping. A covered outdoor area is visible, along with a clear sky, creating a serene and peaceful setting.
Cottage in Patagonia
4.97 out of 5 average rating, 114 reviews

Country house with spectacular views

Disconnect from your worries in this spacious and serene private space, where you can enjoy natural light, contact with nature and beautiful natural views. It has a fully equipped kitchen, dining room, living room, living room with TV and reclining armchairs, 3 large bedrooms, a game room, laundry room and a beautiful porch where you can rest in the living room or in the outdoor dining room as well as enjoy beautiful sunsets. It also has a kiosk with lighting.

Top guest favorite
A refreshing saltwater pool is framed by a spacious deck, lined with comfortable lounge chairs. The surrounding landscape features native plants and offers expansive views of the desert terrain and distant mountains under a dramatic sky.
Cottage in Patagonia
4.96 out of 5 average rating, 111 reviews

Kestrel Cottage at Birdsong Retreat

ATTENTION SUMMER BOOKINGS: Swamp cooler and wall unit in queen bedroom. We provide fans. With monsoon rains, it’s too humid to use swamp cooler. Unit is priced to reflect the heat. Escape to serene high desert grasslands in Patagonia, AZ, offering 360-degree views at 4,058 feet offering respite from the Phoenix and Tucson heat. Nestled within BirdSong Retreat on 37 acres, the Kestrel Cottage promises luxurious accommodations and a focus on well-being.

Top guest favorite
The guesthouse features a cozy sleeping area with a spacious bed dressed in simple linens. A comfortable sofa is positioned next to a wood bookshelf, which holds various decorative items. A desk and chair provide a dedicated workspace, with natural light filtering through the curtains.
Guesthouse in Rio Rico
4.87 out of 5 average rating, 355 reviews

Cozy Rio Rico guesthouse with a view

This spacious guesthouse is in an ideal rural setting. Located near the Mexican border, the art community at Tubac, and the old Spanish mission of Tumacacori, there is lots to see and do. (Not to mention many good golf courses.) I am looking forward to your visit! To make your stay both pleasant and sanitary I steam clean floors, sani-wash all linens and towels, and wipe counters, sinks and toilet with sanitizer spray. Rest easy here!

Top guest favorite
A green casita is situated in an open landscape, surrounded by a rustic fence. A gravel driveway leads towards the entrance, with an American flag waving gently overhead. Lush grass and a few scattered trees enhance the rural setting under a clear blue sky.
Home in Sonoita
4.98 out of 5 average rating, 262 reviews

Sky Island Retreat Sonoita, AZ.

Sky Island Retreat is a quiet and peaceful hilltop retreat in which you can relax and enjoy the natural beauty of this historic area. The casita is the original but updated ranch house built in the late 60’s. We have kept much of its original charm while upgrading to modern comfort and conveniences. We are located on a privately gated property just minutes from the heart of Sonoita and Southern AZ’s growing wine country.

Popular amenities for Santa Cruz County vacation rentals