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Vacation rentals in Santa Cruz

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Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Apartment in Puerto Ayora

4.85 out of 5 average rating, 68 reviews

Oceanview Suite: Casa Nido

Escape to our one of a kind, birds nest-inspired suite in Puerto Ayora, Galapagos. Revel in the ocean views from your private balcony, rest in the cozy hanging bed, and ascend the artistic tree staircase. This 21 sqm gem offers a fully-equipped kitchen, speedy Wi-Fi (120 mbps), a workspace, and a ventilated living space. Stroll to nearby bakeries, cafes, and eateries, or let us guide you through the best of the islands. Experience the perfect blend of minimalist elegance and rustic island charm.

Sep 2 – 9

R1,979 ZAR per night

Apartment in Puerto Ayora

5.0 out of 5 average rating, 29 reviews

Bright and cozy 2 bedroom home away from home

Kick back and relax in this calm, stylish space. A bright and comfortable two-bedroom apartment in the heart of the Galapagos, Santa Cruz Island. Surrounded by vegetation, it is situated only four blocks from the main street, five minutes walk from the main dock, and at the entrance of Tortuga Bay. AMAZING terrace with outside dining areas. Perfect for couples or a small group of friends. It offers working spaces, a kitchen, a washing machine, all you need to have your own home in the Galapagos.

Oct 23 – 30

R2,334 ZAR per night

Apartment in Puerto Ayora

4.97 out of 5 average rating, 133 reviews

Modern and spacious apartment in prime location

Our private, bright, spacious apartment is centrally located in Puerto Ayora 1/2 block off Darwin Avenue. The fish market, restaurants, shops, Darwin Station and main pier are just a few minutes walk away. The apartment is equipped with wifi, large kitchen with fridge, induction stovetop and microwave, and a large common area. It is good for couples, families or small groups. There are two bedrooms with A/C and sofa beds so a family group can easily be accommodated. Patio available upstairs.

Oct 5 – 12

R1,839 ZAR per night

Apartment in Puerto Ayora

4.89 out of 5 average rating, 119 reviews

Planet House Apt2 Sunny 1 BR flat. Great location

Beautiful property, with great views and wonderful fresh ocean breeze. Our apartment is located two blocks away of Charles Darwin main avenue. Guests can enjoy a leisurely walk to main attractions like the Charles Darwin Research Station and beach, great restaurants, fish market, cafés, shops, bike rental, dive shops, tour operators and more. Great option for guests seeking flexibility, comfort and good value. The bedroom has AC, however the living area only benefits form a nice sea breeze.

Jul 25 – Aug 1

R1,757 ZAR per night

Apartment in Puerto Ayora

5.0 out of 5 average rating, 15 reviews

Cozy apartment en pleno centro

Disfruta de una experiencia con estilo en este alojamiento céntrico para disfrutar de momentos inolvidables en el paraíso. La casa de 120 metros cuadrados, ofrece dos dormitorios; el primero con una cama doble y baño completo. El segundo con dos camas de 1 ½ plaza. Cocina completamente equipada. En la sala, encontrarás un baño social, conjunto de muebles y comedor. Además de un patio pequeño con un área de lavado y tendido de ropa.

Sep 4 – 11

R1,236 ZAR per night

Apartment in Puerto Ayora

4.95 out of 5 average rating, 143 reviews

Cute and bright two-level apartment!

This recently renovated two level apartment has its own private entrance, accessed via a quiet street. Downstairs there is a small patio and garden, inside is the living room with a small work space, the bedroom with king sized bed and AC, and an ensuite bathroom. Upstairs is a fully equipped bright kitchen with an eat in breakfast bar. Attached to the kitchen is balcony with an outdoor dining area and views of the garden.

Nov 25 – Dec 2

R1,550 ZAR per night

Villa in Santa Cruz

4.95 out of 5 average rating, 143 reviews

Secluded Wooden Cabin with Stunning Ocean Views

Gaze into the endless pacific ocean from this exclusive wooden cabin set in the middle of a fruit farm on the sunny east side of Santa Cruz Island, a 20 minute drive from Puerto Ayora. Here you will have the whole property to yourself and be able to relax in the middle of nature with complete privacy, super fast starlink internet and the opportunity to see endemic animals and wildlife up-close just outside the doorstep.

Jan 28 – Feb 4

R4,712 ZAR per night

Apartment in Puerto Ayora

4.93 out of 5 average rating, 343 reviews

Galapagos studio "Encantadas" Sea

Beautiful bright apartment in a quiet neighborhood. Full equipped. 5 minutes’ walk to the trail to Tortuga Bay and a 5 min walk from the town center. 8 years of experience with Airbnb, 16 years in the tourism business, and hundreds of positive reviews are our best business cards! If you are traveling more than two people, we also have “Galapagos Studio Encantadas Ocean.” We are certified by the Ministry of Tourism

Aug 21 – 28

R1,656 ZAR per night

Bungalow in Puerto Ayora

4.89 out of 5 average rating, 217 reviews

Bright Garden Bungalow in a quiet neighborhood.

Sunshine filled, bright garden suite, next to the entrance to the Galapagos National Park and the Charles Darwin Station, and a few blocks away from some of the best restaurants, art galleries and bars in town. Located on the far end of one of Puerto Ayora's main streets, accessible to the road but removed enough to be isolated from the urban noise.

Aug 6 – 13

R1,341 ZAR per night

Apartment in Puerto Ayora

4.96 out of 5 average rating, 55 reviews

Casa Tuna

Disfruta de tus vacaciones en Galápagos en un hermoso departamento ubicado en un sector residencial de Puerto Ayora , con un estilo único que combina la madera con el blanco , habitaciones confortables con TV, aire acondicionado y baño privado. Además, con una amplia terraza que harán tu estancia inolvidable.

Jan 24 – 31

R2,916 ZAR per night

Treehouse in Puerto Ayora

4.98 out of 5 average rating, 56 reviews

Abnb & Design: Bamboo

Enjoy an unforgettable stay in our little bamboo house. Built and designed by local architects, this property is made with eco-friendly and sturdy materials, which provide the place with unique freshness and warmth thanks to its avant-garde design. You will sleep among Muyuyo trees on top of a cargo container!

Nov 16 – 23

R1,046 ZAR per night

Home in Puerto Ayora

4.95 out of 5 average rating, 42 reviews

The Cactus house

This cozy house is everything you want for your stay on the islands: just a few steps from the main street and the fish market, where all the action happens yet on a quiet street if what you are looking for is just a little rest. lt will be the perfecto spot to start or finish your Galapagos adventure.

Jan 20 – 27

R1,570 ZAR per night

Vacation rentals for every style

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Popular amenities for Santa Cruz vacation rentals

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Other great vacation rentals in Santa Cruz

Vacation home in Puerto Ayora

4.96 out of 5 average rating, 54 reviews

Brand new apartment in the heart of Puerto Ayora

Feb 2 – 9

R3,307 ZAR per night

Guesthouse in Puerto Ayora- playa de los alemanes

4.82 out of 5 average rating, 51 reviews

Galapagos - Isla Santa Cruz -Janine's Chalet

Aug 29 – Sep 5

R7,009 ZAR per night

Home in Puerto Ayora

4.97 out of 5 average rating, 35 reviews

Shangri-La Legal Rental steps to the beach

Feb 21 – 28

R8,268 ZAR per night

Guest suite in Puerto Ayora

4.98 out of 5 average rating, 52 reviews

Nice suite in Puerto Ayora, Galapagos

Aug 23 – 30

R1,083 ZAR per night

Home in Puerto Ayora

5.0 out of 5 average rating, 6 reviews

Furnished Department of Santa Cruz

Aug 2 – 9

R678 ZAR per night

Home in Puerto Ayora

4.88 out of 5 average rating, 33 reviews

Downtown Puerto Ayora apartment

Jun 30 – Jul 7

R684 ZAR per night

Condo in Puerto Ayora

4.82 out of 5 average rating, 22 reviews

Modern loft with ocean and bay view

Jan 5 – 12

R4,083 ZAR per night

Condo in Puerto Ayora

4.91 out of 5 average rating, 22 reviews

Exclusive 3 bedroom condominium Galapagos&Beyond 1

Mar 14 – 21

R5,232 ZAR per night

Destinations to explore