
House vacation rentals in Picayune
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Top-rated house rentals in Picayune
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Vacation rentals for every style
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Popular amenities for Picayune house rentals
House rentals with a pool

Heated Pool, Hot Tub, Boat/Fish Dock, No pet fees!
This was exactly the right choice for our small wedding. The home and yard were ABSOLUTELY BEAUTIFUL. Everything was easy to find in the home, the home was so inviting too! Just really had the best time, everyone in the family that attended also loved it. There were nothing but compliments! And Dick was probably the best host I've ever had. He was on top of things communication-wise! I thank him so much for everything. He really made my wedding so perfect.

Coastal Serenity! Heated Pool/Hot tub!
My fiancé and I, along with our two friends, very much enjoyed our stay with Mrs. Stacey. We checked in very late due to work hours and she was very understanding. She was accommodating to our needs and wants, always quick to respond, and very kind and sweet. We will most definitely be booking with her and her beautiful home again in the future. Hands down a great first impression for our first stay in an Airbnb!

Henley House - Enjoy Pool, Old Town or Beach
I want to say that this was one of the best experiences that we have had at an air bnb it was beautiful the house was beautiful had everything you needed for a beach vacation for sure but I think we only went to the beach once because the pool wasn’t cold and it wasn’t too warm it was just right every time you went in it!! The showers outside were very convenient when wanting to go inside from the pool. If you’re going to rent a house you will not be disappointed in this one whatsoever they even had the best laundry room to do your clothes so you wouldn’t have to do them once you you best home. If I could rate 10 stars I would!!!

Wined Down in a cozy 2br/2ba home on water w/pool
Wanted to take a trip to visit my dad’s grave, at the Veterans National Cemetery in Biloxi, and make a fun little summer vacation trip for the kids. Wined down was located in the perfect spot. The pool and dock helped keep the kids entertained. Wined down also had plenty of entertainment for the stormy days. We felt like we were home and will definitely be back.

Waveland Beach Cottage 213
Super cute house—very clean, comfortable, and the pool and hot tub were fantastic! The only minor inconvenience was the lack of shade in the pool area, and there were only four lounge chairs and four regular chairs, which wasn’t quite enough since the space is shared by five houses. That said, the host was friendly, helpful, and very responsive, which made our stay even better. Overall, we had a great experience and are definitely planning to stay here again!

Heated Salt Pool*Walk2Beach*Mins2BayStLouis*PetsOK
The beach house was amazing. My grandkids loved the pool. The beds were comfortable and there was plenty of room

Your Private Coastal Oasis! Sleeps 8-POOL!
We had a great stay with our family! The host was very responsive with a couple of questions we had during our stay. The house was very clean upon arrival. We would definitely book again! We loved the area and of course the pool! We would definitely recommend this place!

Gulf Moon II - Spacious Beachfront Home with Pool
From the moment we got into the house, we were completely amazed by how beautiful the inside was. Very spacious, welcoming and comfortable. We rented this beach house for our wedding party to stay in. Everyone fit comfortably and had their own space. The bridal party had the second floor to get ready, and the groom and groomsmen had the bottom to get ready. Made staying separate really easy. The pool was the cherry on top. After a long day of wedding activities, it was so nice to relax by the pool outside to end the night with our wedding party. We would definitely stay again.
Weekly house rentals

Peaceful luxury home
This place was great for a relaxing time with wonderful shopping and restaurants! I highly recommend going to downtown Slidell for yummy Tacos.

Albert St Cottage
We came here for a family reunion and this place was centrally located around everything!!! We were able to be at the reunion in no time and all the food everywhere was just so wonderful. Everything about our stay was wonderful. The backyard was beautiful and we got to enjoy it the second day (rained the first) and we even had coffee, water, and popcorn for us if we wanted it. Can’t say anything but wonderful things. It was a wonderful weekend!!! This is the perfect place to stay if you want a weekend away to explore what the area has to offer.

Waterfront property! Private Boat Launch
We cannot begin to tell you how wonderful Malarie was. She answered in a very timely manner and offered suggestions for whatever we asked for. She told us it was about 9 miles from the camp to the beach and that was very accurate. She also gave us suggestions on restaurants and we sent them one as well. The layout is amazing and it has a good atmosphere, with very comfortable furniture in every room. The kids had a great time fishing and crabbing, and every day they did not want to stop. There were more than enough games inside for the family to play together and both TVs worked very well giving us family movie night with no issue. They had enough supplies to get us through the first few days and plenty of dishes. The coffee pot was broken and when I told Malarie she immediately had one brought to us by way of DoorDash. She even included donuts for the kids and coffee. They do have several stairs to get into the camp, but it is well lit and they are in great condition. Highly recommend

NEW!Modern, Cozy, 3BR FarmhouseW/ Private Hot Tub
My wife and I stayed in this Air BNB in Slidell for our anniversary trip in May of 2025. We had an awesome time! We’ve stayed in a lot of places and this one hands down has been the most at home we’ve ever felt. The house was clean, welcoming and so peaceful. Stephanie was wonderful to interact with. She was prompt and made sure we had anything we needed while there. We will definitely be back. Thanks Stephanie!

New, "Old Mandeville" cottage 30 miles to NOLA
We had a wonderful experience! The home was beautiful, spacious, and exactly as described. Haley was incredibly friendly, responsive, and made sure we had everything we needed during our stay. Great communication throughout, and we felt very well taken care of. Highly recommend!

Wonder of Wake!
The house was beautiful my family enjoyed our time there. When we had a question Richie response time was excellent. Will stay again if in that area.

Woodland House Nature Retreat
This house was perfect for our group! My family of 3 stayed in the master bed which gave our baby somewhere to play on the 1st floor without being in everyone’s way. Everyone else got their own room upstairs. We felt right at home and appreciated how well stocked everything was. The swing was great, the location was peaceful, and we will definitely book again if we’re ever in the area!

5BR Luxe Home w/ Bball Court
The house was extremely impeccable from walking in very peaceful surrounding clean my family enjoyed the property. There was anything that you can possibly think of that. Was there everything that I needed each detail each room was very it exceeded my expectations. The pictures absolutely did no justice in real time. All of the rooms were immaculate down to the outside space. The basketball goal was great for my boys and the private suite . I can’t wait to book again.
Private house rentals

Whispering Oaks
I had an absolutely fantastic experience at this Airbnb! The host was incredibly welcoming, responsive, and made sure everything was perfect from check-in to check-out. The place was exactly as described—spotlessly clean, beautifully decorated, and stocked with all the essentials (and then some!). The location was ideal—a quick drive to great restaurants, shops, and other local attractions. This stay exceeded my expectations in every way, and I wouldn’t hesitate to book again or recommend it to others. Thank you for making my trip so enjoyable!

Luxury 3 bedroom home with epic views
If you are looking for a wonderful place to stay on the Mississippi Gulf Coast, look no further. The house is great and looks just like the pictures. The beds were very comfortable, and the house was very spacious. If you are looking to bring a boat, this is the perfect place. Having your personal boat ramp to launch your boat is priceless!!! The canal is plenty deep all the way out to the Gulf, and there is ample dock space for most any boat you plan to bring. Don't worry about parking. There was plenty of room for parking under the house, even with our center console boat under the house, and there was still plenty of covered room under the house for entertaining or just relaxing in the cool evening breeze. The neighbors were wonderful and provided additional recommendations for great fishing spots and where to buy bait. To say the host were amazing would be an understatement. They were very responsive and helpful even before we booked the house. Thanks for a wonderful time!!!

The Salty Dawg Fish Camp
We loved everything about the cabin! The location, the privacy, the items offered in the kitchen to cook with (although we didn’t use any), the games both upstairs and down (again we didn’t have time to use). Our visit was to attend Jeepin the Coast so we were wiped out when we returned each evening. We plan to return again! Thank you so much for opening up your cabin! ❤️

Palm Paradise
Miramar and Destin days are numbered. This homes location along with the amenities and peace factor has me planning my next trip. Dishes and utensils for meals were there along with a fans, throws and pillows provided for additional comfort. The decorations were stylish and modern. The bed was sooo comfortable. The mattress had my husband questioning our mattress choice at home. The area is awesome as a whole but the way the home is tucked away gives a private Jamaica villa feel. If you are a beach lover this home is for you, it is minutes by car. Being a remote worker, I will mostly definitely recommend Ginger home to my friends, family & coworkers that are looking to venture out from the FL area. Ginger was very proactive with instructions to checking in and out. She was responsive to questions during and after our departure. Book your stay with Ginger, you will not regret it. The home was much larger than the picture provides, so don’t be fooled. Book soon! Paradise awaits!

BRs Cabin
This was the perfect location for our stay. The cabin was clean and peaceful. We walked to the lake behind the property and enjoyed the front porch view.

Relax @ Waterfront *fishing*kayaks & private dock
Beth was the most AMAZING host we have ever had! She’s professional, courteous and so accommodating. Made me feel right at home with a friend I had known forever! Thank you my lady for having us and can’t wait to be back💜

Our Fun
Home was as listed. It was a great home within walking distance to shops and restaurants. House was clean and comfortable!

Endless Summer! A Waterfront Home with Dock
Ryan and Holly’s Bay St. Louis home was wonderful. It is well equipped with everything you need. I appreciated the addition of kitchen and bathroom necessities. The home was clean and had a great view. Our kids had a great time fishing off the dock and playing outside. The home is not far from downtown Bay St. Louis with lots a shopping and restaurants. A great stay!
Quick stats about house rentals in Picayune
Total rentals
20 properties
Nightly prices starting at
R540 ZAR before taxes and fees
Total number of reviews
260 reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
10 properties have a dedicated workspace
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- Biloxi Beach
- Tulane University
- Smoothie King Center
- The National WWII Museum
- Get Wet
- Mardi Gras World
- Gulf Island National Seashore
- Mississippi Aquarium
- Fontainebleau State Park
- Saenger Theatre
- Gulfport Beach, MS
- English Turn Golf & Country Club
- Buccaneer State Park
- Grand Bear Golf Club
- Louis Armstrong Park
- Fallen Oak Golf
- Amatos Winery
- Milićević Family Vineyards
- St. Louis Cemetery No. 1
- Olimpic Beach
- New Orleans Jazz Museum
- Money Hill Golf & Country Club
- Henderson Point Beach
- Harrison County Sand Beach