
Vacation rentals in Panhandle Key
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Top-rated vacation rentals in Panhandle Key
Guests agree: these stays are highly rated for location, cleanliness, and more.
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Vacation rentals for every style
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Popular amenities for Panhandle Key vacation rentals
Other great vacation rentals in Panhandle Key
Top guest favorite

Home in Key Colony Beach
5 out of 5 average rating, 7 reviewsKeys to Ohana. Ocean views. Private Pool, Hot Tub
Superhost

Home in Key Largo
4.87 out of 5 average rating, 54 reviewsPrivate Waterfront Home with lots of WATER TOYS
Top guest favorite

Home in Marathon
5 out of 5 average rating, 50 reviewsMovie Theater | HotTub | Pool | Boat/RV/EV Parking
Guest favorite

Home in Marathon
4.92 out of 5 average rating, 12 reviewsEndless Summer
Guest favorite

Home in Marathon
5 out of 5 average rating, 10 reviewsChiquita Waterfront Canal Home
Top guest favorite

Townhouse in Islamorada
5 out of 5 average rating, 13 reviewsPanoramic Oceanside Luxury, Dockage & Gameroom
Superhost

Home in Key Largo
4.91 out of 5 average rating, 58 reviewsTreetops
Guest favorite

Home in Marathon
5 out of 5 average rating, 10 reviewsCaptain's Retreat: Disneyland for Boaters
Destinations to explore
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- Everglades National Park
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- John Pennekamp Coral Reef State Park
- Zoo Miami
- Coral Castle
- Biscayne National Park
- Cannon Beach
- Calusa Beach & Loggerhead Beach
- Cocoa Plum Beach
- Theater of the Sea
- Conch Key
- Far Beach
- Everglades Alligator Farm
- Monkey Jungle
- Horseshoe Beach
- Sea Oats Beach
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- EAA Air Museum
- Windley Key Fossil Reef Geological State Park
- Bahia Honda State Park
- Sandspur Beach
- Keys' Meads
- Long Beach
- Schnebly Redland's Winery & Brewery