
Vacation rentals in Panhandle Key
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Top-rated vacation rentals in Panhandle Key
Guests agree: these stays are highly rated for location, cleanliness, and more.
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Popular amenities for Panhandle Key vacation rentals
Other great vacation rentals in Panhandle Key
Guest favorite

Home in Marathon
4.95 out of 5 average rating, 42 reviewsFlorida Keys Oceanside Utopia
Guest favorite

Home in Marathon
5 out of 5 average rating, 7 reviewsThe Roseate House at Grassy Key
Top guest favorite

Home in Marathon
5 out of 5 average rating, 50 reviewsMovie Theater | HotTub | Pool | Boat/RV/EV Parking
Guest favorite

Home in Marathon
5 out of 5 average rating, 10 reviewsChiquita Waterfront Canal Home
Top guest favorite

Home in Marathon
4.98 out of 5 average rating, 52 reviewsOceanfront with Pool near Sombrero Beach
Guest favorite

Apartment in Islamorada
4.97 out of 5 average rating, 73 reviewsHidden Gem Islamorada | 1st Floor
Top guest favorite

Home in Marathon
5 out of 5 average rating, 59 reviewsLuxury Boating Paradise+Pool+Sailing Kayaks
Superhost

Home in Key Largo
4.91 out of 5 average rating, 58 reviewsTreetops
Destinations to explore
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- Everglades National Park
- Sombrero Beach
- John Pennekamp Coral Reef State Park
- Zoo Miami
- Biscayne National Park
- Coral Castle
- Cannon Beach
- Calusa Beach & Loggerhead Beach
- Cocoa Plum Beach
- Theater of the Sea
- Conch Key
- Far Beach
- Everglades Alligator Farm
- Monkey Jungle
- Sea Oats Beach
- Horseshoe Beach
- Long Key State Park
- EAA Air Museum
- Windley Key Fossil Reef Geological State Park
- Bahia Honda State Park
- Keys' Meads
- Sandspur Beach
- Long Beach
- Schnebly Redland's Winery & Brewery