Vacation rentals in Osborn Medical Center, Phoenix

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Top-rated vacation rentals in Osborn Medical Center, Phoenix

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite

The interior space features an open layout with a cozy sitting area, including a brown couch adorned with white pillows, and a coffee table. The kitchenette is equipped with a refrigerator and modern cabinetry. Natural light enters through large windows, enhancing the warm ambiance.

Guesthouse in Encanto

4.98 out of 5 average rating, 105 reviews

Spacious Midtown guesthouse with full privacy

Welcome to your private casita (tiny home) in the heart of Midtown. Located right across the street from Starbucks, Buffalo Exchange, and the famous Taco Guild, relax comfortably with vaulted ceilings, a spacious layout, outdoor patio, and a quiet bedroom with a Queen-size bed — perfect for solo travelers or couples. Plus, the Light Rail station is walkable, which goes to Uptown, Downtown, the airport, Tempe, and Mesa. You are only: 7 mins to Downtown 9 mins to the Airport 15 mins to Scottsdale

Top guest favorite

A cozy casita is set against a clear blue sky, with a gravel path leading up to it. Two stylish chairs are situated under a wooden pergola, surrounded by potted greenery. Lush trees and a private fence create a sense of seclusion.

Guesthouse in Phoenix

4.98 out of 5 average rating, 231 reviews

Your favorite PHX guesthouse!

Enjoy your stay in this cozy backyard casita, newly remodeled (320 sq. ft.) and complete with full kitchen & bath. Fully enclosed backyard perfect for the pups! Conveniently located off of the Camelback corridor, central to all of Phoenix metro. You'll be close to the airport, restaurants, coffee shops, grocery and entertainment. Within walking distance to the canal for your morning or evening workout. Sleeps 2 people. *All guests must be listed in reservation. Registered guests only*

Top guest favorite

A modern living area features a comfortable sofa with a cozy throw pillow and an armchair in contrasting fabric. A stainless steel refrigerator and stove are visible in the full kitchen, complemented by bright cabinets and a window allowing natural light. Two bar stools are positioned at a kitchen counter.

Guesthouse in Garfield

4.98 out of 5 average rating, 321 reviews

Lux DTPHX 1-Bed Casita w/Private Patio and Laundry

New 1-bedroom private guest house in historic Garfield, just blocks away from downtown Phoenix, First Friday Artwalk, light rail, and a stone's-throw from two of the city's most celebrated eateries - Gallo Blanco, and Welcome Diner. The guest house features a full kitchen, in-unit washer & dryer, AC, private yard, and coded entry gate. There is ample and well-lit on-street parking. On-site gated parking is available for an additional $15 per night. STR Permit: STR-2024-001116 AZ TPT: 21449942

Superhost

A welcoming living area features two brown leather sofas positioned around a vibrant area rug. A coffee table is centered between them, and a television is mounted on a green accent wall. A potted plant adds a touch of greenery, enhancing the space's warmth.

Condo in Encanto

4.9 out of 5 average rating, 172 reviews

The Beverly Bungalow 1BR/BA in the 🖤 of Phoenix

Relax & unwind at our mid-century bungalow in the heart of Phoenix. This 1BR/1BA condo will comfortably sleep 2 (up to 4 using an air mattress). Our condo is complete with a full kitchen, cozy living room & dedicated work space for the WFH professional. Also included is a shared pool/hot tub to cool off on those hot summer days. Located in Midtown center to museums, unique bar & restaurant concepts, Chase Field, The Footprint Center - the list goes on. We hope you enjoy all AZ has to offer!

Top guest favorite

A swimming pool surrounded by a white wall features a pebble tech finish. Two lounge chairs are positioned on the edge of the pool, with green grass along one side. Bright sunlight reflects off the water, creating a shimmering effect.

Guesthouse in Willow

4.97 out of 5 average rating, 121 reviews

Poolside Guesthouse with Private Patio in Midtown

Welcome to the Poolside Guesthouse! Everything has been designed with you in mind to help you enjoy your time in Phoenix! Furniture and fixtures have been selected for your comfort and to help maximize the space. The Poolside Guesthouse has fantastic outdoor spaces for you to enjoy our beautiful weather & offers one of the best central locations with easy access to the airport, shopping, arts district, museums, bars and restaurants. TPT License #21525000 City of Phoenix License #2023-4161

Guest favorite

The exterior of a charming studio guesthouse is visible, showcasing a brown brick facade and a well-kept entrance. A small pathway leads to the door, and palm trees can be seen in the background against a bright blue sky.

Guesthouse in Phoenix College

4.97 out of 5 average rating, 1,251 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Top guest favorite

A cozy bedroom featuring a spacious bed with a custom leather headboard. A large black and white mural of cacti adds character to the room. A modern pendant light hangs above, complementing the warm tones of the wooden bed frame and the textured beige bedding.

Guest suite in Encanto

4.99 out of 5 average rating, 342 reviews

Private, desert-chic casita in vibrant Midtown PHX

Welcome to Casita Amelia, a modern rustic retreat central to all the action Phoenix has to offer. Welcoming and cozy, this newly updated private guest suite has all the luxuries of a modern hotel suite while being quietly tucked away in a cute Midtown neighborhood. Walk to Melrose District. You're also just 5-10 mins by car to Uptown & Camelback Corridor, 10 mins to Downtown (Footprint Center, Chase Field, Arizona Financial), 15 mins to Sky Harbor Airport, and 20 mins to State Farm Stadium.

Guest favorite

The outdoor pool area features a clear blue pool with a gently sloped entry. A green float is positioned in the water. Surrounding the pool are various plants and a shaded patio area with a built-in grill, offering a relaxing space for outdoor activities.

Guesthouse in North Encanto

4.9 out of 5 average rating, 214 reviews

Private Casita w/ Pool* & BBQ in Historic Melrose

*PLEASE READ HOUSE RULES IN "OTHER THINGS TO NOTE" AREA BEFORE BOOKING* Under no circumstance can one book the Airbnb for another guest . This violates our house rules as well as Airbnb policy. Read more under HOUSE RULES for more details. Our cozy casita is located in the Woodlawn Park neighborhood, a short car ride from the Melrose and Willo Districts. Located near some of the best restaurants in Phoenix, this is the perfect stay for visitors who want to explore the local food scene.

Top guest favorite

A communal living space features a comfortable sofa adorned with various textured cushions. A chalkboard wall displays creative messages, while a vibrant red kitchen cabinet adds visual interest. Sunlight enters through double French doors, enhancing the overall ambiance.

Guesthouse in Encanto

5 out of 5 average rating, 356 reviews

Urban Green House The Garden House

The Urban Green House brings farm life to the urban core. We offer fresh eggs from our backyard hens and gardens for guests to enjoy. We also live green-using solar panels, recycling, and composting. Sarah and Ryan live locally and are available to meet any needs that arise. We are located in a quiet and safe 1950s neighborhood, close to local restaurants, coffee shops, Encanto park, direct access to both the I-10 and I-17 freeways, and only 8 miles from Phoenix Sky Harbor Airport.

Top guest favorite

A cozy living area features a brown leather sofa and an armchair in light green. A glass coffee table is centered in front, reflecting light from nearby windows with sheer curtains. Decorative throw pillows and a mirror with a metallic frame enhance the inviting space.

Home in Encanto

4.99 out of 5 average rating, 311 reviews

Marta's Cozy Brick Home in Midtown PHX

Centrally located condo in a peaceful neighborhood with detached carport. Completely renovated and tastefully decorated. Cleaned following the guidelines recommendations from the CDC to prevent spread of COVID-19 and with HEPA air purifier. Cozy Tuft and Needle beds and fully equipped kitchen. Private patios. In walking distance to a variety of restaurants and The Valley Metro Light Rail. City of Phoenix Short-Term Rental Operating Permit # STR-2025-000722

Top guest favorite

A spacious room is anchored by a king bed adorned with crisp white linens and decorative pillows in warm tones. Natural light fills the space through large windows, while a woven rug and a small seating area enhance the inviting atmosphere.

Guest suite in Phoenix

4.94 out of 5 average rating, 492 reviews

Ibiza - Charming, Chic Suite in Biltmore Area

The IBIZA Suite… Single room with private entrance in ideal location. Close to beautiful mountains in the heart of Phoenix. Inviting, shaded courtyard patio in a secure and friendly neighborhood just 2 blocks from great shopping and dining. Suite has a luxurious king bed, work area and coffee station that makes it perfect for a couple, an executive traveler or a single guest. Only 4 minutes from Biltmore Fashion Park and 10 minutes from Sky Harbor Airport.

Superhost

An outdoor patio area is visible, featuring a large umbrella providing shade. A comfortable seating arrangement includes a sofa adorned with colorful pillows. Potted plants add greenery, while natural stone flooring enhances the inviting space, surrounded by soft drapes that frame the area.

Home in Encanto

4.88 out of 5 average rating, 251 reviews

Entire Private apartment, historic downtown

Your Private Retreat in Historic Downtown Phoenix Welcome to a private one-bedroom apartment—a peaceful, fully self-contained space with a separate entrance and a private patio. Nestled in the historic district of downtown Phoenix, this cozy getaway offers a quiet, quaint, and friendly atmosphere, perfect for relaxing after exploring the city. https://airbnb.com/rooms/1091526274311397985?source_impression_id=p3_1711840500_ibQfEDNzHJanWqtP