Vacation rentals in Osborn Medical Center, Phoenix

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Top-rated vacation rentals in Osborn Medical Center, Phoenix

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite

A historic guesthouse is framed by a mix of stone and soft greenery. The outdoor area features a stone pathway, bordered by low shrubs, leading to a covered seating area under a wooden gazebo. Sunlight fills the scene, highlighting the inviting residence.

Guesthouse in Encanto

4.97 out of 5 average rating, 203 reviews

Best Little Guesthouse in Melrose !

Historic guesthouse in the heart of the Melrose District! EV charger! Walking distance to restaurants, bars, coffee shops, the famous Melrose Vintage shops, grocery stores, LA Fitness and more! Want to head downtown to Chase Field, Talking Stick Arena for a game or a show? Campbell Street Light Rail station is only five short blocks away! No need for a car, you can take the Light Rail from Sky Harbor International Airport, save your money for entertainment! Off street parking if you have a car!

Guest favorite

An inviting outdoor area is illuminated by soft lighting, surrounded by lush palm trees. A rectangular lap pool reflects the evening sky, accompanied by spacious green lawns and comfortable lounge chairs. The scene evokes a sense of tranquility and relaxation in a private resort-like setting.

Guest suite in Encanto

4.97 out of 5 average rating, 279 reviews

Clothing Optional Love Shack 2 Hot Tub & Pool

Nude art. Intimate room with private entrance. Palm lined st in Central Phx. Very safe. Close to restaurants, groceries, light rail and arts. Luxury king bed w/sexyprivate full bath, dresser, TV and mini split A/C and heat. Organic linens. Breakfast items. Nude/clothing opt. large, private, resort yard for sun bathing with lap pool, nude hot tub and couples outdoor rain shower. Soap up. Perfect for first/full time nudists. We have two rooms to rent + Clothing Optional Love shack. Massages avail

Superhost

A welcoming living area features two brown leather sofas positioned around a vibrant area rug. A coffee table is centered between them, and a television is mounted on a green accent wall. A potted plant adds a touch of greenery, enhancing the space's warmth.

Condo in Encanto

4.89 out of 5 average rating, 177 reviews

The Beverly Bungalow 1BR/BA in the 🖤 of Phoenix

Relax & unwind at our mid-century bungalow in the heart of Phoenix. This 1BR/1BA condo will comfortably sleep 2 (up to 4 using an air mattress). Our condo is complete with a full kitchen, cozy living room & dedicated work space for the WFH professional. Also included is a shared pool/hot tub to cool off on those hot summer days. Located in Midtown center to museums, unique bar & restaurant concepts, Chase Field, The Footprint Center - the list goes on. We hope you enjoy all AZ has to offer!

Top guest favorite

A living room features a vibrant blue patterned wall and a plush green sofa set. An abstract art piece is displayed above a stylish table, while a zebra-striped rug lies beneath. Soft lighting from hanging fixtures enhances the room's inviting design.

Home in Coronado

4.95 out of 5 average rating, 296 reviews

Vintage French Film Set in Heart of Coronado

Rest well in a space that feels like a vintage French film set - a one-off vision of a Phoenix designer. 1931 duplex reimagined for unique looks AND function by a team with deep Airbnb experience. Combo of vintage and new, original and updated, everything here is designed for a memorable and comfortable experience. Short walk to some of the best foodie and coffeehouse destinations of Phoenix, 5 minutes to downtown, and yet in the heart of one of the most vibrant neighborhoods Downtown Phoenix.

Guest favorite

The pool area is surrounded by lush tropical landscaping, with shaded seating nearby. Sunshades provide protection from the sun over the shimmering water, creating a serene atmosphere. Natural stones and greenery enhance the tranquil setting, inviting relaxation and enjoyment.

Place to stay in Phoenix

4.96 out of 5 average rating, 1,050 reviews

Guest House 1 King Bed Pool/Jacuzzi/urban Phoenix

“CHECKING IN INSTRUCTIONS”at “GUEST RESOURCES”on Airbnb. PLEASE NO EARLY CHECK-IN due to time constraints. The guest room air conditioner/heater/king size bed/linens/Plates/glasses-all plastic, towels/wifi/premium cable with movies Premium internet. Guest house 275 sq feet There is street parking with parking permit available. Alwa NO SMOKING of any products inside guest house Property 420 friendly only in outdoor spaces QUIET HOURS between 10:00 pm-5:00 am pool/hot tub close 10:00pm

Top guest favorite

A swimming pool surrounded by a white wall features a pebble tech finish. Two lounge chairs are positioned on the edge of the pool, with green grass along one side. Bright sunlight reflects off the water, creating a shimmering effect.

Guesthouse in Willow

4.97 out of 5 average rating, 131 reviews

Poolside Guesthouse with Private Patio in Midtown

Welcome to the Poolside Guesthouse! Everything has been designed with you in mind to help you enjoy your time in Phoenix! Furniture and fixtures have been selected for your comfort and to help maximize the space. The Poolside Guesthouse has fantastic outdoor spaces for you to enjoy our beautiful weather & offers one of the best central locations with easy access to the airport, shopping, arts district, museums, bars and restaurants. TPT License #21525000 City of Phoenix License #2023-4161

Guest favorite

The exterior of a charming studio guesthouse is visible, showcasing a brown brick facade and a well-kept entrance. A small pathway leads to the door, and palm trees can be seen in the background against a bright blue sky.

Guesthouse in Phoenix College

4.97 out of 5 average rating, 1,268 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Top guest favorite

A modern sleeping area features a spacious bed adorned with textured pillows. Natural light illuminates the room, enhancing the minimalist decor of framed artwork on the walls. A cozy bench and nightstand complement the design, while a private entrance is visible in the background.

Guesthouse in Story

5 out of 5 average rating, 104 reviews

Downtown Phoenix Private Casita - Story & Sol

Story & Sol is a new, fully equipped casita in the heart of FQ Story neighborhood in Downtown Phoenix. Stroll palm-lined streets and admire historic Arizona homes with charming landscapes as you discover all that Phoenix has to offer. Truly a cozy oasis in the heart of the City... minutes from restaurants, coffee shops, bars, farmers markets, & museums. Located off the I-10, Story & Sol is the perfect launch pad for adventures across the Valley of the Sun in our beautiful Grand Canyon state.

Guest favorite

The outdoor pool area features a clear blue pool with a gently sloped entry. A green float is positioned in the water. Surrounding the pool are various plants and a shaded patio area with a built-in grill, offering a relaxing space for outdoor activities.

Guesthouse in North Encanto

4.9 out of 5 average rating, 220 reviews

Private Casita w/ Pool* & BBQ in Historic Melrose

*PLEASE READ HOUSE RULES IN "OTHER THINGS TO NOTE" AREA BEFORE BOOKING* Under no circumstance can one book the Airbnb for another guest . This violates our house rules as well as Airbnb policy. Read more under HOUSE RULES for more details. Our cozy casita is located in the Woodlawn Park neighborhood, a short car ride from the Melrose and Willo Districts. Located near some of the best restaurants in Phoenix, this is the perfect stay for visitors who want to explore the local food scene.

Top guest favorite

A communal living space features a comfortable sofa adorned with various textured cushions. A chalkboard wall displays creative messages, while a vibrant red kitchen cabinet adds visual interest. Sunlight enters through double French doors, enhancing the overall ambiance.

Guesthouse in Encanto

5 out of 5 average rating, 359 reviews

Urban Green House The Garden House

The Urban Green House brings farm life to the urban core. We offer fresh eggs from our backyard hens and gardens for guests to enjoy. We also live green-using solar panels, recycling, and composting. Sarah and Ryan live locally and are available to meet any needs that arise. We are located in a quiet and safe 1950s neighborhood, close to local restaurants, coffee shops, Encanto park, direct access to both the I-10 and I-17 freeways, and only 8 miles from Phoenix Sky Harbor Airport.

Top guest favorite

A spacious living area contains a light grey loveseat and a small wooden desk paired with a chair. A decorative lamp provides soft lighting beside the couch. Artwork is displayed on the wall above the desk, and large windows allow natural light to fill the room.

Guesthouse in Willow

5 out of 5 average rating, 222 reviews

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)

Guest favorite

A cozy and inviting guest space is framed by wooden shelving, displaying various decorative items and plants. A spacious bed is positioned in the center, complemented by soft lighting from a ceiling fan. Windows allow natural light to brighten the area, enhancing its warmth.

Guest suite in Encanto

4.94 out of 5 average rating, 271 reviews

Charming Guesthouse w/ Full Kitchen & Pool

You'll love your private stay in our charming space, centrally located in Phoenix's historic Melrose District. It's perfect for folks staying several days: powerful air conditioning, private laundry room, and access to a kitchen and our outdoor pool. You'll be a 10 minute drive from downtown Phoenix and a 15 minute drive from Sky Harbor Airport. With a private entrance and a dedicated covered parking spot, your stay couldn't be more convenient!