Vacation rentals in Osborn Medical Center, Phoenix

4.95 out of 5 average rating, 663 reviews

A welcoming living area features white brick walls illuminated by natural light. Comfortable seating includes a patterned sofa, a butterfly chair, and woven accents. A round coffee table rests on a textured rug, complemented by decorative plants and a large abstract painting on the wall.

Home in Encanto

Elegantly Renovated Bungalow in a Historic District

This home was renovated by a professional designer (@designxwoods) and showcases unique details and inspiring finishes around every corner! Soak in the natural light in the airy and open living space wrapped in white brick and even venture up the ladder to the loft for a meditate moment. From the retro furnishings and oak hardwood floors to the spa-like bathrooms, the home is warm and charming and filled with amenities to make your stay comfortable. It is perfect for larger groups or families wanting a cozy stay near the best restaurants and shops Phoenix has to offer. The brick paved back patio offers a great al fresco dining option with the beautiful Arizona sunsets. Disclaimer: For your safety of our property and our guests, one surveillance camera has been installed on the front porch. Guests have access to the entire home, including back patio. PLEASE NOTE: The loft is accessed via a steel ladder that is secured to the wall. We ask that guests use ladder carefully and at their own risk. We are always available via telephone or through the app. The house is in the Coronado Historic District, a quiet residential community of young families and artists. Several restaurants and coffee shops are within walking distance. Downtown Phoenix is a 5-minute drive away. Guests are welcome to park on the gravel driveway, two cars can fit tandem. We have a two car maximum at the property. PLEASE NOTE: The listing photos were taken before the window treatments were installed. The master bedroom currently has a blackout drapery panel. The guest bedrooms have blackout roller shades and the living room windows have privacy roller shades.

A historic guesthouse is framed by a mix of stone and soft greenery. The outdoor area features a stone pathway, bordered by low shrubs, leading to a covered seating area under a wooden gazebo. Sunlight fills the scene, highlighting the inviting residence.

4.96 out of 5 average rating, 180 reviews

Best Little Guesthouse in Melrose !

Historic guesthouse in the heart of the Melrose District! EV charger! Walking distance to restaurants, bars, coffee shops, the famous Melrose Vintage shops, grocery stores, LA Fitness and more! Want to head downtown to Chase Field, Talking Stick Arena for a game or a show? Campbell Street Light Rail station is only five short blocks away! No need for a car, you can take the Light Rail from Sky Harbor International Airport, save your money for entertainment! Off street parking if you have a car!

A fenced yard features a concrete pathway leading to a white casita, surrounded by greenery. A large tree provides shade, and garden landscaping is visible, enhancing the outdoor space. A seating area with chairs is located to one side.

4.96 out of 5 average rating, 169 reviews

Adorable Casita in Historic Central Phoenix.

Keep it simple at this peaceful and centrally-located place. This Willo casita is near downtown, unique restaurants, shopping and museums. 1/2 mile from the Light Rail and 10 min to Sky Harbor Airport. The Recently Updated Casita is off the main house but has its own fenced in yard. We have a fridge, microwave, induction cooktop, and Keurig for coffee. Washer/Dryer unit is outside and shared with main house but available if necessary. Sleeps 3 comfortably with pull out sofa. Street parking.

4.9 out of 5 average rating, 165 reviews

A welcoming living area features two brown leather sofas positioned around a vibrant area rug. A coffee table is centered between them, and a television is mounted on a green accent wall. A potted plant adds a touch of greenery, enhancing the space's warmth.

Condo in Encanto

The Beverly Bungalow 1BR/BA in the 🖤 of Phoenix

Relax & unwind at our mid-century bungalow in the heart of Phoenix. This 1BR/1BA condo will comfortably sleep 2 (up to 4 using an air mattress). Our condo is complete with a full kitchen, cozy living room & dedicated work space for the WFH professional. Also included is a shared pool/hot tub to cool off on those hot summer days. Located in Midtown center to museums, unique bar & restaurant concepts, Chase Field, The Footprint Center - the list goes on. We hope you enjoy all AZ has to offer!

The exterior of a charming studio guesthouse is visible, showcasing a brown brick facade and a well-kept entrance. A small pathway leads to the door, and palm trees can be seen in the background against a bright blue sky.

4.97 out of 5 average rating, 1,234 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

4.99 out of 5 average rating, 326 reviews

A cozy bedroom featuring a spacious bed with a custom leather headboard. A large black and white mural of cacti adds character to the room. A modern pendant light hangs above, complementing the warm tones of the wooden bed frame and the textured beige bedding.

Guest suite in Encanto

Private, desert-chic casita in vibrant Midtown PHX

Welcome to Casita Amelia, a modern rustic retreat central to all the action Phoenix has to offer. Welcoming and cozy, this newly updated private guest suite has all the luxuries of a modern hotel suite while being quietly tucked away in a cute Midtown neighborhood. Walk to Melrose District. You're also just 5-10 mins by car to Uptown & Camelback Corridor, 10 mins to Downtown (Footprint Center, Chase Field, Arizona Financial), 15 mins to Sky Harbor Airport, and 20 mins to State Farm Stadium.

4.96 out of 5 average rating, 136 reviews

A spacious backyard features a sparkling pool surrounded by lounge chairs and palm trees. The main house is visible in the background, showcasing large windows and shaded patio areas. A serene and inviting atmosphere is created by the well-maintained landscaping.

Home in Encanto

Paradise, Conferences, Dbacks, w/Guesthouse, Pool

Enjoy this completely renovated 3-bedroom house, together with a separate, self-contained Guesthouse. Located in the beautiful Willo District of Central Phoenix - just 10 minutes from Sky Harbor Airport, Downtown, Convention Center, & major freeways. it is ideally suited for large families or groups in town for either business or pleasure. The resort-like feel is enhanced with a beautiful backyard patio & pool (ask about heating) offering guests the ultimate in both relaxation and fun.

A bedside table features a Smart Home device, providing convenient voice control. The stylish headboard frames a spacious bed adorned with crisp white bedding. Soft lighting enhances the clean and modern decor of the room, creating an inviting atmosphere.

4.97 out of 5 average rating, 183 reviews

PHX's Modern Midtown Carriage House, Free Parking

Experience the perfect blend of historic charm and modern comfort in the heart of Phoenix's Midtown. Our beautifully designed Carriage House offers a unique guest quarters, complete with a full kitchen, luxurious bedding, and a private patio. Step outside and explore the vibrant neighborhood, filled with local restaurants, shops, and cultural attractions. Book your stay at the Midtown Carriage House today and discover the best of Phoenix living. check out on insta @midtowncarriagehouse

A communal living space features a comfortable sofa adorned with various textured cushions. A chalkboard wall displays creative messages, while a vibrant red kitchen cabinet adds visual interest. Sunlight enters through double French doors, enhancing the overall ambiance.

5 out of 5 average rating, 351 reviews

Urban Green House The Garden House

The Urban Green House brings farm life to the urban core. We offer fresh eggs from our backyard hens and gardens for guests to enjoy. We also live green-using solar panels, recycling, and composting. Sarah and Ryan live locally and are available to meet any needs that arise. We are located in a quiet and safe 1950s neighborhood, close to local restaurants, coffee shops, Encanto park, direct access to both the I-10 and I-17 freeways, and only 8 miles from Phoenix Sky Harbor Airport.

4.99 out of 5 average rating, 298 reviews

A cozy living area features a brown leather sofa and an armchair in light green. A glass coffee table is centered in front, reflecting light from nearby windows with sheer curtains. Decorative throw pillows and a mirror with a metallic frame enhance the inviting space.

Home in Encanto

Marta's Cozy Brick Home in Midtown PHX

Centrally located condo in a peaceful neighborhood with detached carport. Completely renovated and tastefully decorated. Cleaned following the guidelines recommendations from the CDC to prevent spread of COVID-19 and with HEPA air purifier. Cozy Tuft and Needle beds and fully equipped kitchen. Private patios. In walking distance to a variety of restaurants and The Valley Metro Light Rail. City of Phoenix Short-Term Rental Operating Permit # STR-2025-000722

A spacious living area contains a light grey loveseat and a small wooden desk paired with a chair. A decorative lamp provides soft lighting beside the couch. Artwork is displayed on the wall above the desk, and large windows allow natural light to fill the room.

5 out of 5 average rating, 209 reviews

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)