
Guesthouse vacation rentals in Mount Pleasant
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Top-rated guesthouse rentals in Mount Pleasant
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Mount Pleasant guesthouse rentals
Family-friendly guest house rentals

Charleston's Coolest Neighborhood

Salt of the Island Retreat w/ Pool on the Lake

Riverland Terrace Guesthouse

Cottage apartment near beach and downtown

Boho Converted Garage Apt. - Cozy & Convenient!

Creekside Cottage (Tiny Home)

Mother in Law in James Island Riverland Terrace

Olde Village Loft - Unique Park Circle Experience
Guest house rentals with a patio

Quaint Cottage Studio in Ashley Forest (Avondale).

Studio 77 in dt Charleston with bikes

Farm Stay w Gardens, Cute Animals, Firepit + Porch

Driftwood Cottage

My Happy Place

The Violet Villa w/no cleaning fee

The James: “Tiny” Home b/w Downtown & Folly

Cozy Cottage! 5 mins from Kiawah!
Guest house rentals with a washer and dryer

Peaceful Garden Cottage Retreat

Cozy Apartment in Mount Pleasant

Cozy Cottage w Games, Firepit, Grill, and More!

Private Coastal Cottage-Near Beaches & Charleston!

James Island "La Casita" Nestled btw Beach & City

Summerville’s Tiny Oak Hideaway

Charming Guest Cottage in Old Mount Pleasant, SC

Serene Location - Next to Hampton Park: Haven Hom
Quick stats about guesthouse rentals in Mount Pleasant
Total rentals
50 properties
Total number of reviews
6.6K reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
20 properties have a dedicated workspace
Wifi availability
50 properties include access to wifi
Destinations to explore
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- Villa rentals Mount Pleasant
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- Luxury rentals Mount Pleasant
- Guesthouse rentals Charleston County
- Guesthouse rentals South Carolina
- Guesthouse rentals United States
- Park Circle
- Hunting Island State Park Beach
- Sullivan's Island Beach
- Bulls Island
- Middleton Place
- Waterfront Park
- James Island County Park
- The Golf Club at Wescott Plantation
- Shem Creek Park
- Harbor Island Beach
- Hampton Park
- Angel Oak Tree
- The Charleston Museum
- Morris Island Lighthouse
- Isle of Palms Beach
- Hunting Island Beach
- Seabrook Island Beach
- Charleston Aqua Park
- Gibbes Museum of Art
- White Point Garden
- Seabrook Beach
- Whirlin' Waters Adventure Waterpark
- Splash Zone Waterpark At James Island County Park
- Front Beach IOP
- Things to do Mount Pleasant
- Nature and outdoors Mount Pleasant
- Things to do Charleston County
- Nature and outdoors Charleston County
- Art and culture Charleston County
- Food and drink Charleston County
- Tours Charleston County
- Sports activities Charleston County
- Sightseeing Charleston County
- Things to do South Carolina
- Sports activities South Carolina
- Entertainment South Carolina
- Nature and outdoors South Carolina
- Food and drink South Carolina
- Wellness South Carolina
- Art and culture South Carolina
- Sightseeing South Carolina
- Tours South Carolina
- Things to do United States
- Sightseeing United States
- Art and culture United States
- Wellness United States
- Entertainment United States
- Sports activities United States
- Tours United States
- Food and drink United States
- Nature and outdoors United States