Vacation rentals in Isthmus of Panama

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Top-rated vacation rentals in Isthmus of Panama

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Top guest favorite

The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.

Guesthouse in El Valle de Antón

4.99 out of 5 average rating, 99 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Top guest favorite

A modern living area features a light-colored sofa adorned with colorful cushions. A round coffee table sits on a textured rug, while a dining table for six is visible in the background. Large windows present striking views of the city skyline.

Apartment in Panama City

5 out of 5 average rating, 32 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Guest favorite

An expansive view of a tranquil beach is seen, with soft sandy shores meeting clear turquoise waters. The horizon features a blend of blue sky and distant buildings, while palm trees and shaded cabanas dot the beach area.

Condo in Chame District

4.96 out of 5 average rating, 164 reviews

Exclusive Beachfront apartment 1Hour from Pma City

ESPECTACULAR apartamento de lujo FULL EQUIPADO con 3 recamaras (todas con vista directa al mar), 2 baños completos y medio baño de visita; cuarto y baño de servicio. Finos acabados, cocina 100% de acero inoxidable y aires acondicionados en todo el apartamento de alta eficiencia. Condominio con concepto "Hotel Style Living"; Restaurante y Bar para las noches (de Jueves a Domingo), snack bar en el area de la piscina y un Tiki Bar en la playa, ademas de cancha de Volleyball , Tenis, basketball.

Top guest favorite

An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.

Home in Costa Esmeralda

4.98 out of 5 average rating, 176 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with solar and battery backup systems.

Guest favorite

The modern house is set amidst lush greenery, featuring a sleek design with large glass windows. An infinity pool is positioned on a spacious patio that offers unobstructed views of the surrounding hills, creating an inviting outdoor space for relaxation.

Home in Altos del Maria

4.8 out of 5 average rating, 295 reviews

Modern House with Great Views and Heated Pool

Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Guest favorite

A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.

Apartment in Panamá

4.98 out of 5 average rating, 143 reviews

Escape to the Heart of Casco with a Private Balcony

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Guest favorite

The outdoor area features a private pool, illuminated with soothing blue tones, alongside sun loungers partially submerged in the water. Soft lighting highlights the modern architecture of the house and its spacious terrace, providing a relaxing ambiance under the evening sky.

Home in Vista Mar Golf, Beach & Marina

4.89 out of 5 average rating, 256 reviews

Luxurious Beach House - Private Pool Golf & Marina

Vista Mar Golf, Beach & Marina is a gated community with private security, with direct access to a state of the art golf course designed by J. Michael Poellot. It also has marina, heliport, tennis courts, direct private beach access, bars and restaurants. The house comes with an outdoor private pool & hot tub, also a amazing private outdoor kitchen, and an amazing sea view with spectacular sunrises and sunsets. any inquiry please contact 66168596

Top guest favorite

An aerial view captures the lush greenery surrounding the treehouse, which extends over tranquil waters. The vibrant blue and green hues of the lagoon contrast with the shoreline, showcasing the natural beauty of the area. Mangroves frame the water's edge, emphasizing the secluded environment.

Treehouse in Provincia de Bocas del Toro

4.93 out of 5 average rating, 233 reviews

Cocovivo Mangrove Treehouse

This secluded loft-style treehouse sits on stilts above the water, 30 feet from our colorful coral reef. Transparent and airy but bug proof walls let you enjoy the fresh ocean breeze and views while keeping you safe and cozy. When a sloth comes to visit, no need to leave the house to see him! Blend in with the surroundings of mangrove, lagoon and jungle, and enjoy water and reef access from your own deck. Bright and airy, 100% eco-conscious.

Guest favorite

An infinity pool blends seamlessly into the ocean view, with a person standing at the edge. A lounge chair is positioned nearby, providing a relaxing spot to enjoy the scenery under a clear blue sky.

Condo in San Carlos

4.96 out of 5 average rating, 126 reviews

New ocean apartment in beautiful beach complex

Modern new condo with breath taking views of the Pacific Ocean. We are in a beautiful new beach complex, Punta Caelo, with direct beach access, a beach club, and several large swimming pools. The Social Area is resort quality with deck chairs, infinity pools, billiards, children’s pools and pool beds. The apartment is open and spacious with a fully stocked kitchen and large terrace directly looking out over the ocean.

Top guest favorite

A covered patio area displays a mix of seating options, including two wicker chairs and a small glass-top table surrounded by greenery. A hammock hangs gracefully in the foreground, adding a touch of comfort to this relaxed outdoor setting.

Cottage in El Valle de Antón

4.99 out of 5 average rating, 137 reviews

Casa Campestre Los Macos, El Valle de Anton

🏡 Welcome to Casa Campestre Los Macos, a cozy retreat located in the green heart of El Valle de Antón, within an extinct volcanic crater, the largest inhabited in the world. It is an experience of total rest, in a safe and quiet area, ideal for lovers of nature, silence and fresh air. Wake up to the sound of birds singing, enjoy a cup of coffee in the garden, and spend family evenings in a fully equipped house.

Guest favorite

A cozy living area features a light-colored sofa facing a wall-mounted television. A round table is set in front, and woven placemats add texture. Large windows showcase city views and provide natural light, while a bedroom is visible in the background, showcasing a spacious bed.

Apartment in Panamá

4.98 out of 5 average rating, 107 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Top guest favorite

A modern beachfront building rises against a bright blue sky, with large windows reflecting the surroundings. Thatched-roof cabanas are visible on the sandy beach, bordered by lush greenery. The structure stands in a tranquil setting, inviting relaxation and enjoying ocean views.

Loft in Rio Hato

5 out of 5 average rating, 29 reviews

Beachfront Loft in Farallón

Wake up to the ocean in this beautiful beachfront loft in Farallón, located in the exclusive Miramar Loft next to the Decameron Hotel. Relax on the balcony with sea views, enjoy the pool, and walk to the beach with private cabanas on the sand. The apartment offers 2 bedrooms, a full kitchen, A/C throughout, and fast Wi-Fi. Just 2 hours from Panama City. Book now and live the beach experience you deserve!