Boutique hotel vacation rentals in Iowa

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Iowa

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Hotel room in Allerton

4.73 out of 5 average rating, 11 reviews

Inn of the Six-Toed Cat -- Rosalie Room

Inn of the Six-Toed Cat, where you can take life a little slower at an authentic turn of the century Inn. We have common rooms for guests to relax, read, play games or watch TV/movie. We provide a wonderful breakfast with warm hospitality. Near by is the highly acclaimed Prairie Trails Museum (in Corydon), Bob White park, Round Barn, Amish country, golfing and lost of little antique stores in the neighboring towns. Come enjoy the front porch lifestyle, and let us be your home away from home.

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Hotel room in Ankeny

The Best Spot for a Relaxing Getaway! W/ Pool, Gym

While staying with us, unwind and take advantage of everything the city has to offer. Our property in Ankeny is near I-35. Drake University, Principal Park, and the Iowa State Capitol in Des Moines are all about 15 minutes away. Big Creek State Park, located on Saylorville Lake, is a short 25-minute drive away. The distance to Ankeny Regional Airport will be 10 minutes. Enjoy a complimentary hot breakfast each morning before heading out on a day of adventure. Parking and Wi-Fi are also free.

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Hotel room in McGregor

4.89 out of 5 average rating, 18 reviews

American House 1854- Stagecoach Stop Suite

Take in the beauty of the Mississippi River at this unique and tranquil getaway. The American House Inn is the oldest standing building in McGregor, IA. Built in 1854, this building is on the National Registry of Historic Places and takes you back to the late 1800s but with modern amenities. Located just across the street from Big Bouys Marina, Kwik Star and a block from the Sadie’s Sweet Ice Cream shop! You don’t want to miss enjoying all of the history and the beauty of this vintage gem!

Hotel room in Kanawha

5 out of 5 average rating, 4 reviews

The Mainline Depot Pedersen Suite for 2

You will feel right at home in this charming luxury studio apartment suite located in an old 1900's Farmer's State Bank. This unique suite has a queen sized bed with a stunning antique chandelier. There is a full sized kitchen with quartz counters that has everything you need and an inviting dining room to eat your meals. Snuggle up on the stylish sofa and enjoy the a cozy electric fireplace and cable TV. (See separate listing to include the bunk room that sleeps an additional 6 guests!

Hotel room in Centerville

Private Townhome Apartment in Historic Hotel

Offering elegance, history, and genuine hospitality, The Continental Hotel is southern Iowa’s premier boutique hotel. A hidden gem on the historic Centerville Square, our 28-room hotel dates to 1866. We have hosted a number of famous historical figures including Booker T. Washington and Carrie Nation. The Continental has a restaurant, Lucile's, on the main level that serves lunch and dinner. Free continental breakfast is available here and is included with your stay.

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Hotel room in Le Claire

4.93 out of 5 average rating, 15 reviews

River View Lodge - King Suite 202

Welcome to our luxurious King Suite! This elegant suite features a king-size bed, perfect for a restful night's sleep, and a sofa bed for extra guests. The highlight of the suite is the indulgent jetted tub, where you can unwind and relax after a long day. The large walk-in shower offers a refreshing and invigorating experience. Enjoy entertainment on the flat screen TV and stay connected with free WiFi!

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Hotel room in Le Claire

4.92 out of 5 average rating, 12 reviews

River View Lodge - Golden Suite, Room 102

Discover comfort and relaxation in our luxurious Golden Suite. This suite offers two queen beds, a sofa-bed, 2 walk-in showers, two bathroom stalls and a private sauna. Stay entertained with the flat screen TV, and keep refreshments close at hand with the mini fridge and in-room coffee maker. Enjoy the scenic view of the Mississippi River from your private walkout while staying connected with free WiFi.

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Hotel room in Le Claire

River View Lodge - The Bridal Suite, Room 101

Discover comfort and relaxation in our luxurious Aqua Suite. This suite offers two queen beds, a sofa-bed, 2 walk-in showers, two bathroom stalls and a private sauna. Stay entertained with the flat screen TV, and keep refreshments close at hand with the mini fridge and in-room coffee maker. Enjoy the scenic view of the Mississippi River from your private walkout while staying connected with free WiFi.

Hotel room in Waverly

4.38 out of 5 average rating, 8 reviews

Charming Boutique Country Estate with a pool

No detail is overlooked at this charming and upscale country estate to stay. We have an indoor pool, outdoor basketball courts and pickleball courts, Trager grills available for guests use, outdoor dining area. Plenty of space for your furry friends, we're pet friendly and sit on 10 acres right on the edge of Waverly. Outdoor dog park, book your stay today.

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Hotel room in Washington

4.91 out of 5 average rating, 33 reviews

King Suite - Dodici Night Suites

Above the famous Dodici Cafe Restaurant in beautiful downtown Washington, This suite is newly built in 2016. King size bed with sitting area and bath Extra bedroom with queen size bed Other Amenities: Private Bath with Hair Dryer and Bath Products, Air-conditioning, Refrigerator, Microwave, Coffee Maker, Dining Table, TV, Free Wi-Fi

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Hotel room in Clear Lake

4.83 out of 5 average rating, 24 reviews

Lakeside Inn - Clear Lake - Standard King

Charming king room at the newly renovated Lakeside Inn in Clear Lake, IA. In addition to the brand new renovations, you'll also enjoy a one of a kind view of the gorgeous lake. Offering an array of rooms, some with patios, we are here to make your stay an experience to remember.