Guesthouse vacation rentals in Durham County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Durham County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A cozy guest room features a spacious bed with crisp linens, a small dining table with two chairs, and a comfortable couch. Natural light fills the space through multiple windows, creating a bright atmosphere on warm wooden flooring.

Guesthouse in Durham

4.95 out of 5 average rating, 200 reviews

New Scent-Free Eco-Friendly Guesthouse Near Duke!

New-construction (2022) spotlessly clean farmhouse-style guesthouse is 3 mins to Duke, 15 mins to UNC and 25 mins to Raleigh. Perfect for an RTP work trip or weekend alumni or family/student visit. Explore Durham (8 min drive to downtown Durham, DPAC, American Tobacco, etc.) or anywhere in the Triangle from this South Durham location in the charming Tuscaloosa-Lakewood neighborhood. Walking distance to a supermarket, Cocoa Cinnamon coffee shop and restaurants serving breakfast, lunch and dinner.

Top guest favorite

A light-colored, two-story garage apartment is surrounded by a professionally landscaped garden, featuring diverse plants and a stone pathway. The structure showcases multiple windows that invite natural light, with a welcoming entrance under an overhang, framed by lush greenery.

Guesthouse in Durham

4.99 out of 5 average rating, 508 reviews

Light-filled Guesthouse Near Duke

Second floor of recently-built garage apartment in a charming, peaceful Durham neighborhood. Twenty minutes to RDU Airport, five minutes to Duke's East Campus and ten minutes to West Campus, we are an easy walk to a range of locally-owned restaurants. Lovely, light-filled apartment has a bedroom, full kitchen and living area, bathroom, private entrance, and patio with seating. Occasionally, we may have first-floor space available at extra cost. Well-behaved pets welcome. See below for fees.

Top guest favorite

A modern kitchen features vibrant turquoise cabinetry paired with neutral countertops. Stainless steel appliances, including a refrigerator and stove, are present. A small table with two bar stools occupies one corner, while a window allows natural light to fill the space.

Guesthouse in Durham

4.95 out of 5 average rating, 338 reviews

Modern Cottage With a Vintage Twist Near Downtown

Come stay at our modern vintage guesthouse in Historic Trinity Park. Our cottage has all modern appliances with vintage fixtures. Our cottage is a cozy, lived-in retreat with rustic charm. This 380 square foot cottage is located in a very lively and safe neighborhood just minutes from downtown Durham. Walk one mile on the Ellerbe creek trail to downtown! Walk 1.5 mile to 9th street restaurants and shops 1 mile to Central Park and farmers market <1 mile to bars and restaurants on geer street

Top guest favorite

The exterior view of the studio guest house is presented, showcasing a soft blue facade and a warm wooden door. Sunlight filters through nearby trees, casting playful shadows on the wall. A wooden fence outlines the property, enhancing the sense of privacy.

Guesthouse in Durham

4.96 out of 5 average rating, 142 reviews

Little House Old North Durham

Welcome to our little house in Old North Durham. The 380 square foot studio guest house (open concept) sits behind our Bungalow in a centrally located historic neighborhood.; a 15-20 minute walk to Durham's vibrant Central Park District and a little further to downtown. Close by restaurants, music, movies and shows. Sleeps 2 comfortably on queen bed, and 2 additional on convertible couch from IKEA. Living area joins kitchen and is open to bedroom (see photos). Vaulted ceilings create openness.

Guest favorite

The exterior of a two-story orange-clad cabin is shown, featuring a green door and multiple windows. A wooden deck with railing is visible, framed by trees and low shrubbery. The natural surroundings contribute to a tranquil setting.

Guesthouse in Durham

4.87 out of 5 average rating, 220 reviews

Lovely Studio with King Sized Tempur-Pedic

Experience the beauty of Duke Forest in your back yard! Cozy and quiet in the trees, yet 2 miles from Duke University. King sized tempur-pedic for an amazing nights sleep. Our wonderful studio apartment boasts a well-equipped kitchenette, a Roku device to access your streaming apps’ accounts. A beautiful, private deck with panoramic views of Duke Forest. Walk right onto Sheperd's Trail, curated by Duke University, from the back yard. 2 miles to Duke Hospital. 3 miles to downtown Durham.

Top guest favorite

A light gray sectional sofa is positioned in the foreground, adorned with a soft green and cream throw blanket. Behind it, a modern kitchen is visible, featuring white cabinetry, floral wallpaper, and stainless-steel appliances, creating a cohesive and functional living space.

Guesthouse in Durham

5 out of 5 average rating, 26 reviews

East Campus Spacious Guest house

You'll have plenty of space in this beautiful, sun-soaked, fully-stocked, 1-bedroom guest house. Literally just steps from Duke's East Campus, you have easy access to everything. It's a short walk to two grocery stores (including Whole Foods), restaurants, shops, and a popular walking/jogging loop, and just a mile and a half to downtown or Duke hospital. Or stay in and lounge on the massive deck, cook a meal in the full-sized kitchen, or stream your favorite shows in this brand-new space.

Guest favorite

A compact studio features a spacious bed covered in a neutral quilt. A cozy armchair is positioned beside the bed, and a small kitchenette is visible with contemporary cabinetry. Soft lighting creates a comfortable setting, with framed artwork displayed on the walls.

Guesthouse in Durham

4.93 out of 5 average rating, 106 reviews

Studio on Tobacco Road

Whether you're coming to work or play, Studio on Tobacco Road is a perfectly positioned launch pad to experience Durham & Chapel Hill. Just 6 miles to Downtown Durham's renowned breweries & culinary scene, experience its creative arts culture & explore its rich history. Minutes from your home court, 4 miles to Duke. 5 miles to UNC. All from a beautifully designed studio on a quiet, nature-rich landscape less than a mile from Duke Forest. Gravel drive was recently paved! Photos to come!

Top guest favorite

A spacious studio apartment is presented with a large window allowing natural light to illuminate the room. A king-sized bed is complemented by a cozy sofa and two nightstands. Additional seating is provided by a patterned armchair, enhancing the room's functionality.

Guesthouse in Durham

5 out of 5 average rating, 30 reviews

“Meelie Doll”~ Private - Cozy Stdio Apt abv garage

Cute Studio apt, w/private entrance, nestled in the trees, including major amenities along with prkg on premises. Relax after a long day out by strolling the quiet neighborhood to get your steps in. Close to RTP and all Major Co.'s in the pk. Close to all Major Trigle Collges, Univ.'s & Hospitals including Duke, UNC, NC St. all within 15-20 mins away. 10 mins to RDU Airpt, Shopping & Restaurants. You will Love it!! If longer stay is needed please contact me.

Superhost

A spacious studio is highlighted by a light blue accent wall. A comfortable bed is adorned with decorative pillows. A modern kitchenette features white cabinetry, while a small seating area includes an accent chair and side table. Large windows provide natural light and a view of the outdoors.

Guesthouse in Durham

4.82 out of 5 average rating, 11 reviews

Sleek Renovated Studio Just (2).Downtown Durham

Welcome to our modern, fully equipped studio just 1 minute from Downtown Durham! Enjoy high-speed Wi-Fi, a smart TV, kitchenette, and a luxurious bathroom with a spa-style shower. Perfect for business or leisure, with a private entrance and self check-in. Walk to restaurants, DPAC, and Duke. Centrally located for easy access to all Durham offers. Ideal for solo travelers or couples seeking comfort, style, and convenience. Book your relaxing retreat today!

Guest favorite

A light-filled living area is showcased with large windows that offer views of greenery. A modern sofa adorned with colorful throw pillows is complemented by a round coffee table on a patterned area rug. The kitchen, featuring turquoise cabinetry, is visible in the background.

Guesthouse in Durham

4.93 out of 5 average rating, 106 reviews

Duplex filled with natural light

A stylish, modern, and beautiful alley guesthouse that is located just 2 blocks from Duke's East Campus and 4 blocks from downtown Durham. The apartment is located in the historic Trinity Park Neighborhood in Durham. The apartment has a top of the line finish, hardwood floors, appliances, and furniture. The loft area is equipped with a standing desk and monitor and 2 Yoga matts, and it is ideal for working professionals visiting the area. Built: 2023

Superhost

A cozy living area features warm wooden paneling and an inviting brown leather sofa. Bright blue cabinetry contrasts with the darker kitchen appliances. Natural light fills the space, highlighting a colorful area rug and providing a welcoming atmosphere for relaxation.

Guesthouse in Rougemont

4.9 out of 5 average rating, 208 reviews

Cozy Cottage on a Hilltop

Private cottage for people & pets (please indicate what kind of pets you are bringing). The cottage offers beautiful views of the countryside overlooking the pastures. There is a private seating area by the side of the cottage where you can enjoy amazing sunrises with a cup of coffee or cocktails in the evening. My 2 acres of property offer privacy and quiet atmosphere to enjoy a peaceful retreat. Please let me know the ETA the day of the arrival.

Top guest favorite

A light-filled living area features a comfortable beige sofa facing a wooden entertainment unit, which is adorned with baskets and decorative items. A ceiling fan provides airflow, while a table with a lamp adds to the room's functionality. Windows allow natural light to enter.

Guesthouse in Durham

5 out of 5 average rating, 18 reviews

Duke Forest Hideaway

Enjoy some tranquil time at our Duke Forest Hideaway. The guest house is located inside our safe gated property adjacent our 35 acre horse farm. Just outside the front door you will have access to a mile of wooded walking trails around the farm. Just 2 miles from Duke, 5 miles from downtown Durham UNC you are still in the center of everything! The unit has a private entrance and parking, patio, stocked full kitchen, and washer dryer.